STRINGSTRING
TCF7L1 TCF7L1 CASP14-2 CASP14-2 NCKAP1 NCKAP1 DYNC1I2 DYNC1I2 RHOG RHOG KPNA1 KPNA1 EXOC5 EXOC5 RHOJ RHOJ AKT3 AKT3 SNX9 SNX9 DYNLT1 DYNLT1 RPS3 RPS3 PAK2 PAK2 PFN1 PFN1 PIK3CB-2 PIK3CB-2 PIK3CB PIK3CB TNFSF10 TNFSF10 PPP2CA PPP2CA TCF7 TCF7 MAPK9 MAPK9 MAP2K1-2 MAP2K1-2 SNX33 SNX33 FBXO22 FBXO22 RAB7B RAB7B PIK3C2B PIK3C2B TRAF6 TRAF6 PIK3C2A PIK3C2A TNFRSFA TNFRSFA GAPDH GAPDH TNFRSF1A TNFRSF1A CYFIP1 CYFIP1 TRAF2 TRAF2 TLR4 TLR4 AKT3-2 AKT3-2 NLRC4-1 NLRC4-1 ARPC5 ARPC5 LEF1 LEF1 PLEKHM2 PLEKHM2 RAB7A RAB7A MAPK8 MAPK8 FOS FOS RIPK3L RIPK3L TRADD TRADD IL1B IL1B LY96 LY96 Y1Q_0013899 Y1Q_0013899 Y1Q_0005393 Y1Q_0005393 IKBKG IKBKG AKT2 AKT2 DYNC1I1 DYNC1I1 Y1Q_0019264 Y1Q_0019264 RAB5A RAB5A DYNC1LI1 DYNC1LI1 NOD1 NOD1 CUNH19orf25 CUNH19orf25 BRK1 BRK1 RHOA RHOA MAP3K7 MAP3K7 MYO6 MYO6 CYTH1 CYTH1 VPS39 VPS39 PIK3C3 PIK3C3 SNX18 SNX18 KLC3 KLC3 FLNB-2 FLNB-2 VPS16 VPS16 CDC42 CDC42 ARPC5L ARPC5L RELA RELA RAB9A RAB9A MAP2K3 MAP2K3 CYTH3 CYTH3 MAP2K6 MAP2K6 EXOC7 EXOC7 ARF6 ARF6 PIK3CD PIK3CD DYNLL1 DYNLL1 CXCL8A CXCL8A CXCL8-2 CXCL8-2 MYL10 MYL10 IL8L1 IL8L1 DYNLL2 DYNLL2 DYNC1LI2 DYNC1LI2 ROCK2 ROCK2 MAPK14 MAPK14 ARF2B ARF2B CASP18 CASP18 CASP8-1 CASP8-1 KPNA3 KPNA3 TLR5 TLR5 ARHGEF26 ARHGEF26 KPNA3-2 KPNA3-2 FLNA FLNA PTPRC PTPRC PYCARDL PYCARDL IKBKB-2 IKBKB-2 FHOD1-2 FHOD1-2 IRAK1 IRAK1 MYL5 MYL5 MYL12A MYL12A TXN TXN EXOC2 EXOC2 RIPK1 RIPK1 TIRAP TIRAP IL18 IL18 ELMO3 ELMO3 CYTH4 CYTH4 TAB1 TAB1 PIK3C2G-2 PIK3C2G-2 Y1Q_0008411 Y1Q_0008411 BAX BAX NFKBIA NFKBIA TAB2 TAB2 DYNLRB2 DYNLRB2 NFKB1 NFKB1 RAB9B RAB9B Y1Q_0015577 Y1Q_0015577 PAK3 PAK3 RILP RILP PIK3CG PIK3CG EXOC4-2 EXOC4-2 PODXL-1 PODXL-1 CD14 CD14 TNF TNF RAB5B RAB5B MAPK1 MAPK1 VPS33A VPS33A MYL2 MYL2 ARPC3 ARPC3 FLNB FLNB CASP1 CASP1 TLR2A TLR2A DYNLT3 DYNLT3 Y1Q_0020451 Y1Q_0020451 ACTB ACTB CASP7 CASP7 DNM2 DNM2 MYL7 MYL7 CYFIP1-2 CYFIP1-2 MAP2K1 MAP2K1 NLRP3 NLRP3 CSE1L CSE1L MYL9 MYL9 DYNLRB1 DYNLRB1 TREH TREH CXCL8-3 CXCL8-3 RALA RALA VPS41 VPS41 ELMO1-2 ELMO1-2 FYCO1 FYCO1 CTNNB1 CTNNB1 HSP90AA1 HSP90AA1 PFN3 PFN3 DYNC2LI1 DYNC2LI1 BAK1 BAK1 TNFRSF10B TNFRSF10B M6PR M6PR BIRC2 BIRC2 DYNC2H1 DYNC2H1 KLC4 KLC4 DYNC1H1 DYNC1H1 HSP90AA1-2 HSP90AA1-2 RHOH RHOH CASP3 CASP3 PLEKHM1 PLEKHM1 MYD88 MYD88 Y1Q_0001234 Y1Q_0001234 MAPK12 MAPK12 IRAK4 IRAK4 MAPK11 MAPK11 RIPK2 RIPK2 RIPK3 RIPK3 IKBKB IKBKB RHOB RHOB Y1Q_0020245 Y1Q_0020245 BRAF BRAF PFN4 PFN4 c-jun c-jun
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF7L1Transcription factor 7-like 1 isoform D. (567 aa)
CASP14-2Uncharacterized protein; Belongs to the peptidase C14A family. (249 aa)
NCKAP1Uncharacterized protein. (1119 aa)
DYNC1I2Cytoplasmic dynein 1 intermediate chain 2 isoform C. (726 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
KPNA1Importin subunit alpha; Belongs to the importin alpha family. (515 aa)
EXOC5Exocyst complex component 5. (708 aa)
RHOJRho-related GTP-binding protein RhoJ. (214 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SNX9Sorting nexin. (600 aa)
DYNLT1Dynein light chain Tctex-type 1. (113 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (278 aa)
PAK2Non-specific serine/threonine protein kinase. (546 aa)
PFN1Profilin; Belongs to the profilin family. (139 aa)
PIK3CB-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (295 aa)
PPP2CASerine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
TCF7Transcription factor 7 isoform A. (452 aa)
MAPK9Mitogen-activated protein kinase. (430 aa)
MAP2K1-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
SNX33Sorting nexin. (563 aa)
FBXO22F-box only protein 22. (393 aa)
RAB7BRas-related protein Rab-7b. (207 aa)
PIK3C2BPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform B; Belongs to the PI3/PI4-kinase family. (1673 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (576 aa)
PIK3C2AUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1691 aa)
TNFRSFATumor necrosis factor receptor superfamily member 6-like. (427 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (412 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (601 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
AKT3-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NLRC4-1NLR family CARD domain-containing protein 4 isoform A. (1009 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (141 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform B. (391 aa)
PLEKHM2Pleckstrin-like proteiny domain-containing family M member 2 isoform A. (1062 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FOSProto-oncogene c-Fos isoform A. (530 aa)
RIPK3LReceptor-interacting serine/threonine-protein kinase 2. (564 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (336 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (448 aa)
LY96Lymphocyte antigen 96. (131 aa)
Y1Q_0013899Uncharacterized protein. (103 aa)
Y1Q_0005393EF-hand domain-containing protein. (121 aa)
IKBKGNF-kappa-B essential modulator. (542 aa)
AKT2Non-specific serine/threonine protein kinase. (270 aa)
DYNC1I1WD_REPEATS_REGION domain-containing protein. (675 aa)
Y1Q_0019264Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (129 aa)
RAB5ARas-related protein Rab-5A. (215 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (532 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (951 aa)
CUNH19orf25TIR domain-containing protein. (178 aa)
BRK1Protein BRICK1. (75 aa)
RHOATransforming protein RhoA. (255 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7 isoform A. (610 aa)
MYO6Unconventional myosin-VI isoform A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
CYTH1Uncharacterized protein. (410 aa)
VPS39Vam6/Vps39-like protein. (875 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
SNX18Sorting nexin-18. (512 aa)
KLC3Kinesin light chain 3. (533 aa)
FLNB-2Uncharacterized protein. (2669 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (815 aa)
CDC42Cell division control 42-like protein. (235 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (164 aa)
RELATranscription factor p65. (350 aa)
RAB9ARas-related protein Rab-9A. (201 aa)
MAP2K3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
CYTH3Uncharacterized protein. (515 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (348 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (705 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
DYNLL1Dynein light chain. (123 aa)
CXCL8AInterleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
CXCL8-2Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MYL10Myosin regulatory light chain 10. (166 aa)
IL8L1Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
DYNLL2Dynein light chain. (77 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (489 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1396 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ARF2BADP-ribosylation factor 2b; Belongs to the small GTPase superfamily. Arf family. (210 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (424 aa)
CASP8-1Caspase-8 isoform B; Belongs to the peptidase C14A family. (462 aa)
KPNA3Importin subunit alpha; Belongs to the importin alpha family. (504 aa)
TLR5Toll-like receptor 5. (443 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (590 aa)
KPNA3-2Importin subunit alpha; Belongs to the importin alpha family. (533 aa)
FLNAUncharacterized protein. (2622 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform D. (1209 aa)
PYCARDLApoptosis-associated speck-like protein containing a CARD. (192 aa)
IKBKB-2Uncharacterized protein. (757 aa)
FHOD1-2FH1/FH2 domain-containing protein 1. (1281 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (918 aa)
MYL5Myosin light chain 5. (173 aa)
MYL12AMyosin regulatory light chain 2, smooth muscle minor isoform. (209 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (922 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (699 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (230 aa)
IL18Interleukin-18. (239 aa)
ELMO3Engulfment and cell motility protein 3 isoform A. (673 aa)
CYTH4Uncharacterized protein. (394 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (502 aa)
PIK3C2G-2Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Belongs to the PI3/PI4-kinase family. (495 aa)
Y1Q_0008411Apoptosis regulator BAX-like. (187 aa)
BAXApoptosis regulator BAX. (209 aa)
NFKBIANF-kappa-B inhibitor alpha. (299 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (276 aa)
DYNLRB2Dynein light chain roadblock. (96 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform B. (1031 aa)
RAB9BRas-related protein Rab-9B. (178 aa)
Y1Q_0015577Wiskott-Aldrich syndrome protein family member 3-like. (509 aa)
PAK3Non-specific serine/threonine protein kinase. (526 aa)
RILPRab-interacting lysosomal protein. (152 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (810 aa)
EXOC4-2Uncharacterized protein. (587 aa)
PODXL-1Podocalyxin isoform A. (328 aa)
CD14Monocyte differentiation antigen CD14. (461 aa)
TNFTumor necrosis factor. (231 aa)
RAB5BRas-related protein Rab-5B. (215 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
VPS33AVacuolar protein sorting-associated protein 33A; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (165 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
FLNBFilamin-B. (2598 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (395 aa)
TLR2AToll-like receptor 2 type-1; Belongs to the Toll-like receptor family. (801 aa)
DYNLT3Dynein light chain Tctex-type 3. (116 aa)
Y1Q_0020451Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (281 aa)
ACTBUncharacterized protein. (400 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (319 aa)
DNM2Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (858 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (191 aa)
CYFIP1-2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1289 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (377 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 12. (901 aa)
CSE1LExportin-2. (998 aa)
MYL9Myosin regulatory light polypeptide 9. (212 aa)
DYNLRB1Dynein light chain roadblock. (96 aa)
TREHTrehalase. (1440 aa)
CXCL8-3Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
RALARas-related protein Ral-A. (206 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (867 aa)
ELMO1-2Engulfment and cell motility protein 1. (239 aa)
FYCO1FYVE and coiled-coil domain-containing protein 1. (1545 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (812 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
DYNC2LI1Cytoplasmic dynein 2 light intermediate chain 1. (347 aa)
BAK1Bcl-2-like proteinous antagonist/killer. (222 aa)
TNFRSF10BTumor necrosis factor receptor superfamily member 10B. (394 aa)
M6PRCation-dependent mannose-6-phosphate receptor. (308 aa)
BIRC2Inhibitor of apoptosis protein. (493 aa)
DYNC2H1Uncharacterized protein. (4284 aa)
KLC4Kinesin light chain 4 isoform D. (880 aa)
DYNC1H1Uncharacterized protein. (4633 aa)
HSP90AA1-2HATPase_c domain-containing protein. (771 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (292 aa)
PLEKHM1Pleckstrin-like proteiny domain-containing family M member 1. (1071 aa)
MYD88Myeloid differentiation primary response protein MyD88. (203 aa)
Y1Q_0001234Uncharacterized protein; Belongs to the profilin family. (85 aa)
MAPK12Mitogen-activated protein kinase. (309 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (468 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (561 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3. (508 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (730 aa)
RHOBRho-related GTP-binding protein RhoB. (196 aa)
Y1Q_0020245Ras-like GTP-binding protein RHO. (296 aa)
BRAFSerine/threonine-protein kinase B-raf. (651 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
c-junTranscription factor AP-1; Belongs to the bZIP family. (320 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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