(65 nodes) Embryonic limb morphogenesis network (Crocodylus porosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFT140	Intraflagellar transport 140. (1465 aa)
	FRAS1	Fraser extracellular matrix complex subunit 1. (3991 aa)
	MED1	Mediator complex subunit 1. (1503 aa)
	ENSCPRP00005003679	annotation not available (83 aa)
	OSR2	Odd-skipped related transciption factor 2. (276 aa)
	RPGRIP1L	RPGRIP1 like. (1273 aa)
	FREM2	FRAS1 related extracellular matrix 2. (3086 aa)
	ALX3	ALX homeobox 3. (192 aa)
	MSX1	Msh homeobox 1. (294 aa)
	SALL4	Spalt like transcription factor 4. (1108 aa)
	INTU	Inturned planar cell polarity protein. (912 aa)
	TBC1D32	TBC1 domain family member 32. (1327 aa)
	OSR1	Odd-skipped related transcription factor 1. (238 aa)
	LEF1	Lymphoid enhancer binding factor 1. (412 aa)
	WDR19	WD repeat domain 19. (1342 aa)
	MKS1	MKS transition zone complex subunit 1. (574 aa)
	HOXC11	Homeobox C11. (286 aa)
	TBX5	T-box transcription factor 5. (521 aa)
	TBX3	T-box transcription factor 3. (581 aa)
	FREM3	FRAS1 related extracellular matrix 3. (3180 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SFRP2	Secreted frizzled related protein 2. (465 aa)
	FGF4	Fibroblast growth factor 4. (196 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (129 aa)
	LRP5	LDL receptor related protein 5. (1568 aa)
	PTCH1	Patched 1. (1445 aa)
	HOXD9	Homeobox D9. (291 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (183 aa)
	CYP26B1	Cytochrome P450 26B1. (320 aa)
	RDH10	Retinol dehydrogenase 10. (279 aa)
	CHST11	Carbohydrate sulfotransferase 11. (352 aa)
	PSEN1	Presenilin 1. (468 aa)
	BAX	BCL2 associated X, apoptosis regulator. (193 aa)
	IMPAD1	Inositol monophosphatase domain containing 1. (255 aa)
	GNA12	G protein subunit alpha 12. (396 aa)
	HOXA13	Homeobox A13. (305 aa)
	HOXA11	Homeobox A11. (296 aa)
	ENSCPRP00005023167	annotation not available (92 aa)
	HOXA10	Homeobox A10. (271 aa)
	HOXA9	Homeobox A9. (261 aa)
	NIPBL	NIPBL cohesin loading factor. (2786 aa)
	B9D1	B9 domain containing 1. (206 aa)
	DYNC2H1	Dynein cytoplasmic 2 heavy chain 1. (4302 aa)
	DLX5	Distal-less homeobox 5. (285 aa)
	DLX6	Distal-less homeobox 6. (271 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20. (841 aa)
	HOXD13	Homeobox D13. (339 aa)
	HOXD12	Homeobox D12. (256 aa)
	HOXD11	Homeobox D11. (280 aa)
	HOXD10	Homeobox D10. (339 aa)
	ENSCPRP00005015273	annotation not available (143 aa)
	TBX4	T-box transcription factor 4. (456 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (612 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (205 aa)
	GLI3	GLI family zinc finger 3. (1572 aa)
	BCL2L11	BCL2 like 11. (303 aa)
	IFT52	Intraflagellar transport 52. (458 aa)
	TP63	Tumor protein p63. (647 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (607 aa)
	ENSCPRP00005018796	annotation not available (101 aa)
	ENSCPRP00005018797	annotation not available (283 aa)
	FGF8	Fibroblast growth factor 8. (202 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (935 aa)
	ENSCPRP00005019481	annotation not available (204 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (645 aa)

Your Current Organism:

Crocodylus porosus

NCBI taxonomy Id: 8502
Other names: Australian saltwater crocodile, C. porosus, ZMB 278, estuarine crocodile

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	GLI3	ENSCPRP00005000615	ENSCPRP00005016244	ACD shelterin complex subunit and telomerase recruitment factor.	GLI family zinc finger 3.	0.429
ACD	OSR1	ENSCPRP00005000615	ENSCPRP00005007371	ACD shelterin complex subunit and telomerase recruitment factor.	Odd-skipped related transcription factor 1.	0.429
ACD	OSR2	ENSCPRP00005000615	ENSCPRP00005004206	ACD shelterin complex subunit and telomerase recruitment factor.	Odd-skipped related transciption factor 2.	0.429
ACD	ZBTB16	ENSCPRP00005000615	ENSCPRP00005015841	ACD shelterin complex subunit and telomerase recruitment factor.	Zinc finger and BTB domain containing 16.	0.429
ALX3	HAND2	ENSCPRP00005005197	ENSCPRP00005016206	ALX homeobox 3.	Heart and neural crest derivatives expressed 2.	0.449
B9D1	MKS1	ENSCPRP00005022165	ENSCPRP00005009302	B9 domain containing 1.	MKS transition zone complex subunit 1.	0.940
B9D1	RPGRIP1L	ENSCPRP00005022165	ENSCPRP00005004728	B9 domain containing 1.	RPGRIP1 like.	0.531
B9D1	WDR19	ENSCPRP00005022165	ENSCPRP00005008367	B9 domain containing 1.	WD repeat domain 19.	0.461
BAX	BCL2L11	ENSCPRP00005023836	ENSCPRP00005017272	BCL2 associated X, apoptosis regulator.	BCL2 like 11.	0.969
BAX	TP63	ENSCPRP00005023836	ENSCPRP00005018050	BCL2 associated X, apoptosis regulator.	Tumor protein p63.	0.654
BCL2L11	BAX	ENSCPRP00005017272	ENSCPRP00005023836	BCL2 like 11.	BCL2 associated X, apoptosis regulator.	0.969
CTNNB1	DKK1	ENSCPRP00005012052	ENSCPRP00005013920	Catenin beta 1.	Dickkopf WNT signaling pathway inhibitor 1.	0.655
CTNNB1	ENSCPRP00005019481	ENSCPRP00005012052	ENSCPRP00005019481	Catenin beta 1.	annotation not available	0.782
CTNNB1	GLI3	ENSCPRP00005012052	ENSCPRP00005016244	Catenin beta 1.	GLI family zinc finger 3.	0.430
CTNNB1	LEF1	ENSCPRP00005012052	ENSCPRP00005008179	Catenin beta 1.	Lymphoid enhancer binding factor 1.	0.998
CTNNB1	LRP5	ENSCPRP00005012052	ENSCPRP00005014143	Catenin beta 1.	LDL receptor related protein 5.	0.834
CTNNB1	MAP3K20	ENSCPRP00005012052	ENSCPRP00005020018	Catenin beta 1.	Mitogen-activated protein kinase kinase kinase 20.	0.468
CTNNB1	PSEN1	ENSCPRP00005012052	ENSCPRP00005026352	Catenin beta 1.	Presenilin 1.	0.975
CTNNB1	SFRP2	ENSCPRP00005012052	ENSCPRP00005012960	Catenin beta 1.	Secreted frizzled related protein 2.	0.595
CTNNB1	TBX4	ENSCPRP00005012052	ENSCPRP00005015277	Catenin beta 1.	T-box transcription factor 4.	0.496