STRINGSTRING
recN recN ORC20220.1 ORC20220.1 ORC20225.1 ORC20225.1 recF recF gyrB gyrB gyrA gyrA ORC20258.1 ORC20258.1 recR recR ORC22576.1 ORC22576.1 rplL rplL rplJ rplJ rpsI rpsI rplM rplM rplQ rplQ rpsK rpsK rpmJ rpmJ rplO rplO rpmD rpmD rpsE rpsE rplR rplR rpsH rpsH rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rpsC rpsC rplB rplB rplW rplW rplC rplC rpsJ rpsJ rpsG rpsG rpsF rpsF rpsR rpsR dnaB dnaB ORC25120.1 ORC25120.1 rpmB rpmB rpmG rpmG rpsN rpsN ORC25071.1 ORC25071.1 ORC15287.1 ORC15287.1 ORC15301.1 ORC15301.1 raiA raiA rplT rplT rpmI rpmI rpsO rpsO rpsB rpsB dnaG dnaG rplY rplY ORC15452.1 ORC15452.1 ORC15770.1 ORC15770.1 ORC15754.1 ORC15754.1 ORC16008.1 ORC16008.1 pknB pknB ORC16545.1 ORC16545.1 ORC16456.1 ORC16456.1 ORC16598.1 ORC16598.1 nth nth ORC16410.1 ORC16410.1 ORC16409.1 ORC16409.1 ORC16408.1 ORC16408.1 topA topA ccsB ccsB pdxS pdxS ORC17460.1 ORC17460.1 ORC18935.1 ORC18935.1 ORC18924.1 ORC18924.1 ORC18952.1 ORC18952.1 ORC18804.1 ORC18804.1 ORC22246.1 ORC22246.1 rpmF rpmF ORC22193.1 ORC22193.1 rpsP rpsP ORC22136.1 ORC22136.1 rplU rplU obgE obgE ORC22096.1 ORC22096.1 ORC22089.1 ORC22089.1 ORC22074.1 ORC22074.1 ORC22046.1 ORC22046.1 dtd dtd ORC22042.1 ORC22042.1 priA priA rpsT rpsT ORC22001.1 ORC22001.1 ORC21982.1 ORC21982.1 rpmE2 rpmE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
recNNAD kinase; May be involved in recombinational repair of damaged DNA. (568 aa)
ORC20220.1Stage 0 sporulation protein J; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ParB family. (383 aa)
ORC20225.1Chromosome partitioning protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
recFDNA replication/repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (398 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (675 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (883 aa)
ORC20258.1Chromosome partitioning protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (357 aa)
ORC22576.150S ribosomal protein L36; Derived by automated computational analysis using gene prediction method: Protein Homology. (40 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (126 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (169 aa)
rpsI30S ribosomal protein S9; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS9 family. (162 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
rplQ50S ribosomal protein L17; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
rpmJ50S ribosomal protein L36; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (152 aa)
rpmD50S ribosomal protein L30; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (227 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (186 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (111 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (90 aa)
rpmC50S ribosomal protein L29; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL29 family. (77 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (265 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (278 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (103 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (218 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (101 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (1308 aa)
ORC25120.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
rpmB50S ribosomal protein L28; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmG50S ribosomal protein L33; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL33 family. (56 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
ORC25071.1Integration host factor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial histone-like protein family. (95 aa)
ORC15287.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
ORC15301.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (671 aa)
raiARibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (214 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (127 aa)
rpmI50S ribosomal protein L35; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
rpsB30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (269 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (634 aa)
rplY50S ribosomal protein L25/general stress protein Ctc; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (207 aa)
ORC15452.1Acetylneuraminic acid synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (747 aa)
ORC15770.130S ribosomal protein S1; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
ORC15754.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (867 aa)
ORC16008.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
pknBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (664 aa)
ORC16545.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (730 aa)
ORC16456.1NAD-dependent protein deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
ORC16598.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (309 aa)
ORC16410.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (443 aa)
ORC16409.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (233 aa)
ORC16408.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (943 aa)
ccsBC-type cytochrome biogenesis protein CcsB; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa)
ORC17460.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
ORC18935.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
ORC18924.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (475 aa)
ORC18952.1Pilus assembly protein CpaF; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
ORC18804.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
ORC22246.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (371 aa)
rpmF50S ribosomal protein L32; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL32 family. (67 aa)
ORC22193.1Chromosome segregation protein SMC; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1158 aa)
rpsP30S ribosomal protein S16; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bS16 family. (146 aa)
ORC22136.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (268 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
obgEGTPase ObgE; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (533 aa)
ORC22096.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
ORC22089.1ACP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
ORC22074.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the SOS response-associated peptidase family. (329 aa)
ORC22046.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (144 aa)
ORC22042.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
priAHypothetical protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (699 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
ORC22001.1DNA repair protein RecO; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ORC21982.1RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (946 aa)
rpmE250S ribosomal protein L31; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
Your Current Organism:
Rothia nasimurium
NCBI taxonomy Id: 85336
Other names: CCUG 35957, CIP 106912, JCM 10909, R. nasimurium, Rothia nasimurium Collins et al. 2000, Rothia sp. M7SW7a, Rothia-like sp. CCUG 35957
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