(52 nodes) Alanine, aspartate and glutamate metabolism network (Streptomyces turgidiscabies)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pyrB	Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (325 aa)
	gdhB_3	NAD-specific glutamate dehydrogenase. (1651 aa)
	gadB	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (475 aa)
	nadB_2	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (590 aa)
	glnA_4	Glutamine synthetase. (454 aa)
	T45_07864	D-aspartate ligase. (433 aa)
	rapL_2	L-lysine cyclodeaminase. (326 aa)
	glnA_5	Glutamine synthetase. (469 aa)
	glnII	Glutamine synthetase 2. (342 aa)
	purQ	Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (226 aa)
	purF	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (509 aa)
	T45_08654	Hypothetical protein. (722 aa)
	carB	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1102 aa)
	carA	Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (385 aa)
	T45_08434	Hypothetical protein. (195 aa)
	gabT	4-aminobutyrate aminotransferase GabT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
	puuA	Gamma-glutamylputrescine synthetase PuuA; Belongs to the glutamine synthetase family. (461 aa)
	purA	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
	T45_01217	2-oxoglutaramate amidase. (265 aa)
	alaA_1	Glutamate-pyruvate aminotransferase AlaA. (446 aa)
	purB	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
	gabD1	Succinate-semialdehyde dehydrogenase [NADP(+)]. (464 aa)
	argH	Argininosuccinate lyase. (476 aa)
	argG	Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa)
	glnA_1	Putative glutamine synthetase 2. (456 aa)
	ald_1	Alanine dehydrogenase. (374 aa)
	glnA_2	Glutamine synthetase. (456 aa)
	gltB_1	Glutamate synthase [NADPH] large chain. (1541 aa)
	gltB_2	Glutamate synthase [NADPH] small chain. (486 aa)
	gltB_3	Glutamate synthase [NADPH] small chain. (495 aa)
	glmS_1	Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa)
	glmS_2	Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (615 aa)
	glmS_3	Glutamine--fructose-6-phosphate aminotransferase. (299 aa)
	alaA_2	Glutamate-pyruvate aminotransferase AlaA. (402 aa)
	argD_2	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (428 aa)
	aspC	Aspartate aminotransferase. (415 aa)
	aspA_1	Aspartate ammonia-lyase. (463 aa)
	gdhA	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (396 aa)
	T45_05713	Carbamoyl phosphate synthase-like protein. (385 aa)
	rocA1	1-pyrroline-5-carboxylate dehydrogenase 1. (546 aa)
	ansB	Putative L-asparaginase periplasmic precursor. (334 aa)
	asnO_2	Asparagine synthetase [glutamine-hydrolyzing] 3. (633 aa)
	glnA_3	Putative glutamine synthetase 2. (453 aa)
	ceo	N(5-(carboxyethyl)ornithine synthase. (428 aa)
	asnB	Asparagine synthetase [glutamine-hydrolyzing] 1. (594 aa)
	glmS_4	Glutamine--fructose-6-phosphate aminotransferase. (297 aa)
	T45_07095	L-asparaginase II. (353 aa)
	aspA_2	Aspartate ammonia-lyase. (469 aa)
	glsA	Thermolabile glutaminase; Belongs to the glutaminase family. (318 aa)
	T45_07188	Aspartate aminotransferase. (411 aa)
	T45_07239	D-aspartate ligase. (412 aa)
	gabD2	Putative succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (543 aa)

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_01217	T45_07188	T45_01217	T45_07188	2-oxoglutaramate amidase.	Aspartate aminotransferase.	0.548
T45_01217	alaA_1	T45_01217	T45_01617	2-oxoglutaramate amidase.	Glutamate-pyruvate aminotransferase AlaA.	0.548
T45_01217	alaA_2	T45_01217	T45_04698	2-oxoglutaramate amidase.	Glutamate-pyruvate aminotransferase AlaA.	0.548
T45_01217	ansB	T45_01217	T45_06199	2-oxoglutaramate amidase.	Putative L-asparaginase periplasmic precursor.	0.452
T45_01217	argD_2	T45_01217	T45_04752	2-oxoglutaramate amidase.	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.684
T45_01217	aspC	T45_01217	T45_04838	2-oxoglutaramate amidase.	Aspartate aminotransferase.	0.548
T45_01217	gabT	T45_01217	T45_08062	2-oxoglutaramate amidase.	4-aminobutyrate aminotransferase GabT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.684
T45_01217	gdhA	T45_01217	T45_05576	2-oxoglutaramate amidase.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.691
T45_01217	gltB_1	T45_01217	T45_04042	2-oxoglutaramate amidase.	Glutamate synthase [NADPH] large chain.	0.885
T45_01217	gltB_2	T45_01217	T45_04043	2-oxoglutaramate amidase.	Glutamate synthase [NADPH] small chain.	0.676
T45_01217	gltB_3	T45_01217	T45_04111	2-oxoglutaramate amidase.	Glutamate synthase [NADPH] small chain.	0.714
T45_01217	nadB_2	T45_01217	T45_07545	2-oxoglutaramate amidase.	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.	0.785
T45_01217	purA	T45_01217	T45_00906	2-oxoglutaramate amidase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.406
T45_01217	purQ	T45_01217	T45_08710	2-oxoglutaramate amidase.	Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]	0.455
T45_05713	T45_07239	T45_05713	T45_07239	Carbamoyl phosphate synthase-like protein.	D-aspartate ligase.	0.441
T45_05713	T45_07864	T45_05713	T45_07864	Carbamoyl phosphate synthase-like protein.	D-aspartate ligase.	0.441
T45_05713	T45_08434	T45_05713	T45_08434	Carbamoyl phosphate synthase-like protein.	Hypothetical protein.	0.994
T45_05713	T45_08654	T45_05713	T45_08654	Carbamoyl phosphate synthase-like protein.	Hypothetical protein.	0.519
T45_05713	ansB	T45_05713	T45_06199	Carbamoyl phosphate synthase-like protein.	Putative L-asparaginase periplasmic precursor.	0.536
T45_05713	argG	T45_05713	T45_03298	Carbamoyl phosphate synthase-like protein.	Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.	0.979