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puuA puuA gcvH_2 gcvH_2 gph_2 gph_2 gph_1 gph_1 glyA2 glyA2 gcvH_1 gcvH_1 gcvT_3 gcvT_3 mamA mamA mutE mutE ghrB_2 ghrB_2 accD5_3 accD5_3 T45_05796 T45_05796 lpdC lpdC T45_05510 T45_05510 scpA_4 scpA_4 scpA_3 scpA_3 T45_05211 T45_05211 purU_3 purU_3 merA merA ykfA ykfA mutB_2 mutB_2 garK garK aceB aceB hyi hyi garR_2 garR_2 gcl gcl acsA_2 acsA_2 katE katE kdgA kdgA T45_04326 T45_04326 ghrB_1 ghrB_1 accA1_2 accA1_2 mccF_2 mccF_2 fdhF_2 fdhF_2 pdhD pdhD glnA_2 glnA_2 mutB_1 mutB_1 mutA mutA fdhF_1 fdhF_1 fdnI fdnI T45_03366 T45_03366 T45_03365 T45_03365 glnA_1 glnA_1 eda_2 eda_2 accD5_2 accD5_2 T45_03097 T45_03097 T45_03005 T45_03005 T45_02983 T45_02983 T45_02954 T45_02954 acnA acnA thlA_1 thlA_1 T45_02138 T45_02138 purU_2 purU_2 T45_02053 T45_02053 mce mce glyA_2 glyA_2 accD5_1 accD5_1 accC accC glyA_1 glyA_1 mdh mdh T45_01078 T45_01078 T45_01043 T45_01043 mccF_1 mccF_1 acsA_1 acsA_1 scpA_1 scpA_1 purU_1 purU_1 fadA_1 fadA_1 gcvP gcvP citA citA eda_1 eda_1 accA1_3 accA1_3 T45_09038 T45_09038 hndA hndA T45_08878 T45_08878 glnA_5 glnA_5 arsC arsC glnII glnII T45_08765 T45_08765 ghrB_3 ghrB_3 T45_08699 T45_08699 fdoG fdoG fdnH fdnH gltA2 gltA2 glnA_4 glnA_4 garR_4 garR_4 gph_4 gph_4 scpA_5 scpA_5 maoC_4 maoC_4 katA katA ppaX ppaX T45_06640 T45_06640 glnA_3 glnA_3 accD5_4 accD5_4 gph_3 gph_3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
puuAGamma-glutamylputrescine synthetase PuuA; Belongs to the glutamine synthetase family. (461 aa)
gcvH_2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
gph_2Phosphoglycolate phosphatase. (309 aa)
gph_1Phosphoglycolate phosphatase. (232 aa)
glyA2Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
gcvH_1Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvT_3Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
mamAMethylaspartate mutase S chain. (159 aa)
mutEMethylaspartate mutase E chain. (470 aa)
ghrB_2Glyoxylate/hydroxypyruvate reductase B. (316 aa)
accD5_3Putative propionyl-CoA carboxylase beta chain 5. (535 aa)
T45_05796Cysteine-rich secretory protein family protein. (384 aa)
lpdCDihydrolipoyl dehydrogenase. (470 aa)
T45_055105'-nucleotidase. (226 aa)
scpA_4methylmalonyl-CoA mutase. (146 aa)
scpA_3methylmalonyl-CoA mutase. (526 aa)
T45_05211acetyl-CoA acetyltransferase. (388 aa)
purU_3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (290 aa)
merAMercuric reductase. (478 aa)
ykfAPutative murein peptide carboxypeptidase. (309 aa)
mutB_2methylmalonyl-CoA mutase large subunit. (675 aa)
garKGlycerate 2-kinase; Belongs to the glycerate kinase type-1 family. (389 aa)
aceBMalate synthase; Belongs to the malate synthase family. (543 aa)
hyiHydroxypyruvate isomerase; Belongs to the hyi family. (279 aa)
garR_22-hydroxy-3-oxopropionate reductase. (296 aa)
gclGlyoxylate carboligase; Belongs to the TPP enzyme family. (594 aa)
acsA_2Acetyl-coenzyme A synthetase. (556 aa)
katECatalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (759 aa)
kdgAKHG/KDPG aldolase. (206 aa)
T45_04326Putative FAD-linked oxidoreductase. (466 aa)
ghrB_1Glyoxylate/hydroxypyruvate reductase B. (317 aa)
accA1_2Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (667 aa)
mccF_2Microcin C7 self-immunity protein MccF. (348 aa)
fdhF_2Formate dehydrogenase H; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
pdhDDihydrolipoyl dehydrogenase. (462 aa)
glnA_2Glutamine synthetase. (456 aa)
mutB_1methylmalonyl-CoA mutase large subunit. (724 aa)
mutAmethylmalonyl-CoA mutase small subunit. (602 aa)
fdhF_1Formate dehydrogenase H. (751 aa)
fdnIFormate dehydrogenase, nitrate-inducible. (221 aa)
T45_03366Hypothetical protein. (206 aa)
T45_03365Hypothetical protein. (274 aa)
glnA_1Putative glutamine synthetase 2. (456 aa)
eda_2Putative KHG/KDPG aldolase. (211 aa)
accD5_2Putative propionyl-CoA carboxylase beta chain 5. (520 aa)
T45_03097Hypothetical protein. (119 aa)
T45_03005Hypothetical protein. (164 aa)
T45_02983Putative cyclase. (348 aa)
T45_02954Hypothetical protein. (441 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
thlA_1acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
T45_02138Putative cyclase. (311 aa)
purU_2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (303 aa)
T45_02053Putative acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
mceGlyoxalase/bleomycin resistance protein/dioxygenase superfamily protein. (146 aa)
glyA_2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
accD5_1Putative propionyl-CoA carboxylase beta chain 5. (534 aa)
accCBiotin carboxylase. (590 aa)
glyA_1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (487 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
T45_01078Cysteine-rich secretory protein family protein. (190 aa)
T45_01043Citrate synthase. (271 aa)
mccF_1Microcin C7 self-immunity protein MccF. (296 aa)
acsA_1Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa)
scpA_1methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1077 aa)
purU_1Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa)
fadA_1Putative acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
citACitrate synthase 1; Belongs to the citrate synthase family. (366 aa)
eda_1KHG/KDPG aldolase. (212 aa)
accA1_3Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (621 aa)
T45_09038Putative FAD-linked oxidoreductase. (974 aa)
hndANADP-reducing hydrogenase subunit HndA. (174 aa)
T45_08878NADH-dependent formate dehydrogenase delta. (60 aa)
glnA_5Glutamine synthetase. (469 aa)
arsCArsenate reductase; Belongs to the ArsC family. (124 aa)
glnIIGlutamine synthetase 2. (342 aa)
T45_08765Putative cyclase. (332 aa)
ghrB_3Glyoxylate/hydroxypyruvate reductase B; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (343 aa)
T45_08699Helix-turn-helix domain protein. (68 aa)
fdoGFormate dehydrogenase-O major subunit precursor; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1081 aa)
fdnHFormate dehydrogenase, nitrate-inducible. (307 aa)
gltA2Citrate synthase 1; Belongs to the citrate synthase family. (432 aa)
glnA_4Glutamine synthetase. (454 aa)
garR_42-hydroxy-3-oxopropionate reductase. (289 aa)
gph_4Phosphoglycolate phosphatase. (234 aa)
scpA_5methylmalonyl-CoA mutase. (138 aa)
maoC_4Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase. (149 aa)
katACatalase. (552 aa)
ppaXPyrophosphatase PpaX. (223 aa)
T45_06640Hypothetical protein. (180 aa)
glnA_3Putative glutamine synthetase 2. (453 aa)
accD5_4Putative propionyl-CoA carboxylase beta chain 5. (553 aa)
gph_3Phosphoglycolate phosphatase. (213 aa)
Your Current Organism:
Streptomyces turgidiscabies
NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113
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