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| | priA_1 | Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (241 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | tkt_3 | Transketolase. (86 aa) |
| | tal_5 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa) |
| | dapA_4 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (303 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (329 aa) |
| | dapA_3 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (284 aa) |
| | T45_09221 | Phosphotransferase enzyme family protein. (293 aa) |
| | T45_09207 | Transposase IS116/IS110/IS902 family protein. (415 aa) |
| | fas3_3 | Putative 33.6 kDa protein in fasciation locus. (310 aa) |
| | fas2_2 | Ferredoxin fas2. (296 aa) |
| | T45_09187 | Transposase IS116/IS110/IS902 family protein. (249 aa) |
| | T45_09180 | Hypothetical protein. (100 aa) |
| | T45_09163 | Transposase IS116/IS110/IS902 family protein. (413 aa) |
| | trpA_2 | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | T45_09127 | Hypothetical protein. (201 aa) |
| | T45_09071 | Acetyltransferase (GNAT) family protein. (156 aa) |
| | T45_09070 | Acetyltransferase (GNAT) family protein. (153 aa) |
| | citA | Citrate synthase 1; Belongs to the citrate synthase family. (366 aa) |
| | T45_08961 | Bacterial TniB protein. (344 aa) |
| | yegW | Putative HTH-type transcriptional regulator. (238 aa) |
| | oxc | Putative oxalyl-CoA decarboxylase; Belongs to the TPP enzyme family. (582 aa) |
| | T45_08841 | Hypothetical protein. (356 aa) |
| | T45_08840 | Saccharopine dehydrogenase. (401 aa) |
| | aroE_2 | Quinate/shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (300 aa) |
| | glnA_5 | Glutamine synthetase. (469 aa) |
| | glnII | Glutamine synthetase 2. (342 aa) |
| | ghrB_4 | Glyoxylate/hydroxypyruvate reductase B; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (355 aa) |
| | T45_08654 | Hypothetical protein. (722 aa) |
| | lysA_2 | Diaminopimelate decarboxylase. (467 aa) |
| | T45_08498 | Hypothetical protein. (65 aa) |
| | yqhS_2 | 3-dehydroquinate dehydratase. (167 aa) |
| | hpsN | Sulfopropanediol 3-dehydrogenase; Belongs to the histidinol dehydrogenase family. (175 aa) |
| | tktB_2 | Transketolase 2. (293 aa) |
| | dxs_3 | 1-deoxy-D-xylulose-5-phosphate synthase. (342 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroC_2 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
| | aroE_1 | Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (284 aa) |
| | dat_2 | D-alanine aminotransferase. (273 aa) |
| | serA_5 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (343 aa) |
| | yurK_3 | Putative HTH-type transcriptional regulator. (259 aa) |
| | T45_08291 | Phosphotransferase enzyme family protein. (203 aa) |
| | T45_08290 | Hypothetical protein. (604 aa) |
| | T45_08277 | Transposase IS116/IS110/IS902 family protein. (396 aa) |
| | serA_4 | D-3-phosphoglycerate dehydrogenase. (337 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa) |
| | frlR | HTH-type transcriptional regulator FrlR. (246 aa) |
| | hisE_2 | phosphoribosyl-ATP pyrophosphatase. (90 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | fxsA | Phage T7 F exclusion suppressor FxsA. (199 aa) |
| | dapA_2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | mshD_9 | Mycothiol acetyltransferase. (284 aa) |
| | ectB_2 | Diaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | cobD_2 | Threonine-phosphate decarboxylase. (380 aa) |
| | serB | Phosphoserine phosphatase. (400 aa) |
| | aroA_2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (412 aa) |
| | T45_07901 | Hypothetical protein. (385 aa) |
| | gltA2 | Citrate synthase 1; Belongs to the citrate synthase family. (432 aa) |
| | T45_07883 | Hypothetical protein. (310 aa) |
| | T45_07873 | Secreted chorismate mutase precursor. (208 aa) |
| | T45_07802 | Transposase IS116/IS110/IS902 family protein. (152 aa) |
| | T45_07784 | Hypothetical protein. (240 aa) |
| | glnA_4 | Glutamine synthetase. (454 aa) |
| | T45_07722 | Phosphotransferase enzyme family protein. (350 aa) |
| | T45_07606 | Hypothetical protein. (527 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (617 aa) |
| | argA | Amino-acid acetyltransferase. (177 aa) |
| | ltaE_2 | Low specificity L-threonine aldolase. (392 aa) |
| | T45_07484 | Hypothetical protein. (310 aa) |
| | T45_07355 | Intracellular chorismate mutase. (93 aa) |
| | T45_07188 | Aspartate aminotransferase. (411 aa) |
| | mshD_8 | Mycothiol acetyltransferase. (238 aa) |
| | cysK | Cysteine synthase. (377 aa) |
| | kbaY | D-tagatose-1,6-bisphosphate aldolase subunit. (282 aa) |
| | rpiB_2 | Ribose-5-phosphate isomerase B. (151 aa) |
| | asnB | Asparagine synthetase [glutamine-hydrolyzing] 1. (594 aa) |
| | tdcB_3 | L-threonine dehydratase catabolic TdcB. (340 aa) |
| | T45_06876 | Acetyltransferase (GNAT) family protein. (168 aa) |
| | ltaE_1 | Low specificity L-threonine aldolase. (356 aa) |
| | T45_06630 | Acetyltransferase (GNAT) family protein. (137 aa) |
| | ybbH_2 | Putative HTH-type transcriptional regulator. (303 aa) |
| | pknH_2 | Serine/threonine-protein kinase PknH. (572 aa) |
| | rex | Redox-sensing transcriptional repressor Rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (280 aa) |
| | glnA_3 | Putative glutamine synthetase 2. (453 aa) |
| | asnO_2 | Asparagine synthetase [glutamine-hydrolyzing] 3. (633 aa) |
| | T45_06399 | CBS domain protein. (348 aa) |
| | patA_1 | Putrescine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (533 aa) |
| | T45_06310 | Phosphotransferase enzyme family protein. (163 aa) |
| | T45_06297 | Transposase IS116/IS110/IS902 family protein. (405 aa) |
| | T45_06280 | Hypothetical protein. (110 aa) |
| | T45_06246 | Phosphotransferase enzyme family protein. (344 aa) |
| | tdcB_2 | L-threonine dehydratase catabolic TdcB. (330 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (398 aa) |
| | ybbH_1 | Putative HTH-type transcriptional regulator. (322 aa) |
| | T45_06120 | Helix-turn-helix domain protein. (166 aa) |
| | thrC_4 | Threonine synthase. (442 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa) |
| | T45_06030 | DNA-binding transcriptional repressor LldR. (339 aa) |
| | mngR_5 | mannosyl-D-glycerate transport/metabolism system. (283 aa) |
| | mngR_4 | mannosyl-D-glycerate transport/metabolism system. (294 aa) |
| | mshD_6 | Mycothiol acetyltransferase. (190 aa) |
| | tkt_2 | Transketolase. (88 aa) |
| | tal_4 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (382 aa) |
| | sdaA | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | glyA2 | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa) |
| | T45_05896 | Cobalamin-independent synthase, Catalytic. (333 aa) |
| | ilvB1 | Acetolactate synthase large subunit IlvB1. (617 aa) |
| | ilvH | Acetolactate synthase small subunit. (175 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | serA_3 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (346 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase. (362 aa) |
| | leuA_2 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | T45_05802 | Hypothetical protein. (361 aa) |
| | yvoA_9 | HTH-type transcriptional repressor YvoA. (264 aa) |
| | tal_3 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (382 aa) |
| | tkt_1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (691 aa) |
| | T45_05724 | PHP domain protein. (557 aa) |
| | T45_05687 | Hypothetical protein. (301 aa) |
| | T45_05600 | Phosphotransferase enzyme family protein. (231 aa) |
| | fas3_2 | Putative 33.6 kDa protein in fasciation locus. (301 aa) |
| | fas2_1 | Ferredoxin fas2. (250 aa) |
| | T45_05560 | Hypothetical protein. (492 aa) |
| | hom_2 | Homoserine dehydrogenase. (364 aa) |
| | argF_2 | Ornithine carbamoyltransferase. (326 aa) |
| | trpD_2 | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (359 aa) |
| | trpG | Anthranilate synthase component 2. (196 aa) |
| | sgcD | 2-amino-4-deoxychorismate synthase. (507 aa) |
| | pspA_6 | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. (219 aa) |
| | dat_1 | Diaminobutyrate-2-oxoglutarate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (484 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa) |
| | T45_05365 | Caudovirus prohead protease. (502 aa) |
| | T45_05224 | Hypothetical protein. (258 aa) |
| | T45_05222 | Acetyltransferase (GNAT) family protein. (302 aa) |
| | thrC_3 | Threonine synthase. (440 aa) |
| | patB | Cystathionine beta-lyase PatB. (396 aa) |
| | icd | Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (739 aa) |
| | T45_04980 | Hypothetical protein. (327 aa) |
| | T45_04955 | Hypothetical protein. (295 aa) |
| | yvoA_8 | HTH-type transcriptional repressor YvoA. (261 aa) |
| | T45_04944 | Hypothetical protein. (245 aa) |
| | hmp_3 | Flavohemoprotein; Belongs to the globin family. (399 aa) |
| | cfiB | 2-oxoglutarate carboxylase small subunit. (1150 aa) |
| | aspC | Aspartate aminotransferase. (415 aa) |
| | tktB_1 | Transketolase 2. (623 aa) |
| | dapE_4 | Succinyl-diaminopimelate desuccinylase. (434 aa) |
| | T45_04768 | Hypothetical protein. (245 aa) |
| | yvoA_7 | HTH-type transcriptional repressor YvoA. (245 aa) |
| | alaA_2 | Glutamate-pyruvate aminotransferase AlaA. (402 aa) |
| | hprA | Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa) |
| | serA_2 | D-3-phosphoglycerate dehydrogenase. (337 aa) |
| | T45_04483 | Phosphotransferase enzyme family protein. (280 aa) |
| | T45_04475 | Hypothetical protein. (324 aa) |
| | fbaA | Putative fructose-bisphosphate aldolase. (277 aa) |
| | ectB_1 | Diaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa) |
| | btrK_2 | L-glutamyl-[BtrI acyl-carrier protein]. (442 aa) |
| | ilvB | Acetolactate synthase isozyme 1 large subunit; Belongs to the TPP enzyme family. (562 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa) |
| | gap2_2 | Glyceraldehyde-3-phosphate dehydrogenase 2. (334 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa) |
| | gltB_3 | Glutamate synthase [NADPH] small chain. (495 aa) |
| | pyk_2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) |
| | tyrA | T-protein. (114 aa) |
| | gltB_2 | Glutamate synthase [NADPH] small chain. (486 aa) |
| | gltB_1 | Glutamate synthase [NADPH] large chain. (1541 aa) |
| | trpA_1 | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpE_4 | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (492 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (141 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (221 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa) |
| | aroH_3 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (450 aa) |
| | pfkA1_2 | 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa) |
| | trpD_1 | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa) |
| | T45_03838 | Hypothetical protein. (418 aa) |
| | polX | DNA polymerase/3'-5' exonuclease PolX. (370 aa) |
| | btrK_1 | L-glutamyl-[BtrI acyl-carrier protein]. (403 aa) |
| | fas3_1 | Putative 33.6 kDa protein in fasciation locus. (198 aa) |
| | glnA_2 | Glutamine synthetase. (456 aa) |
| | T45_03690 | Putative glutamine amidotransferase. (239 aa) |
| | T45_03682 | Putative DNA-binding transcriptional regulator. (307 aa) |
| | T45_03609 | Carboxynorspermidine synthase. (405 aa) |
| | aroH_2 | Chorismate mutase AroH. (120 aa) |
| | T45_03568 | Prephenate dehydrogenase. (362 aa) |
| | yvoA_6 | HTH-type transcriptional repressor YvoA. (249 aa) |
| | dapE_3 | Putative succinyl-diaminopimelate desuccinylase. (447 aa) |
| | pspA_2 | Phosphoserine phosphatase 1. (228 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1172 aa) |
| | T45_03347 | Putative glutamine amidotransferase. (249 aa) |
| | glnA_1 | Putative glutamine synthetase 2. (456 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (303 aa) |
| | argD_1 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa) |
| | argH | Argininosuccinate lyase. (476 aa) |
| | T45_03234 | Transposase IS116/IS110/IS902 family protein. (151 aa) |
| | T45_03147 | Hypothetical protein. (270 aa) |
| | pfkA1_1 | 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | ypeA | Acetyltransferase YpeA. (141 aa) |
| | yvoA_5 | HTH-type transcriptional repressor YvoA. (253 aa) |
| | T45_03007 | Acetyltransferase (GNAT) family protein. (408 aa) |
| | argF_1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (335 aa) |
| | arcB | Ornithine carbamoyltransferase, catabolic. (355 aa) |
| | gap2_1 | Glyceraldehyde-3-phosphate dehydrogenase 2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (342 aa) |
| | acnA | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa) |
| | dasR_2 | HTH-type transcriptional repressor DasR. (256 aa) |
| | eno_2 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (436 aa) |
| | cbs_2 | Putative cystathionine beta-synthase. (163 aa) |
| | cbs_1 | Putative cystathionine beta-synthase. (462 aa) |
| | eno_1 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | T45_02497 | Hypothetical protein. (249 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (330 aa) |
| | rsmA_2 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (310 aa) |
| | yvoA_4 | HTH-type transcriptional repressor YvoA. (252 aa) |
| | yvoA_3 | HTH-type transcriptional repressor YvoA. (256 aa) |
| | vapC5 | Ribonuclease VapC5. (142 aa) |
| | mtnN | 5'-methylthioadenosine/S-adenosylhomocysteine. (292 aa) |
| | T45_02082 | Hypothetical protein. (229 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | pyk_1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa) |
| | glyA_2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | thrC_2 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa) |
| | hom_1 | Homoserine dehydrogenase. (429 aa) |
| | lysA_1 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) |
| | mngR_2 | mannosyl-D-glycerate transport/metabolism system. (252 aa) |
| | serA_1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (343 aa) |
| | ysnE | Putative N-acetyltransferase YsnE. (177 aa) |
| | T45_01935 | Acetyltransferase (GNAT) family protein. (219 aa) |
| | dasR_1 | HTH-type transcriptional repressor DasR. (254 aa) |
| | aroA_1 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa) |
| | hisN | Histidinol-phosphatase. (266 aa) |
| | dapE_1 | Succinyl-diaminopimelate desuccinylase. (359 aa) |
| | dapL | LL-diaminopimelate aminotransferase. (363 aa) |
| | mshD_1 | Mycothiol acetyltransferase. (300 aa) |
| | mngR_1 | mannosyl-D-glycerate transport/metabolism system. (250 aa) |
| | thrC_1 | Threonine synthase. (425 aa) |
| | T45_01716 | Hypothetical protein. (346 aa) |
| | alaA_1 | Glutamate-pyruvate aminotransferase AlaA. (446 aa) |
| | tdcB_1 | L-threonine dehydratase catabolic TdcB. (412 aa) |
| | metB_2 | Cystathionine gamma-synthase. (384 aa) |
| | maf | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (207 aa) |
| | glyA_1 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (487 aa) |
| | yvoA_2 | HTH-type transcriptional repressor YvoA. (179 aa) |
| | pheA | Prephenate dehydratase. (310 aa) |
| | pat_1 | Putative phenylalanine aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa) |
| | metB_1 | Cystathionine gamma-synthase. (389 aa) |
| | T45_01228 | Homoserine kinase. (479 aa) |
| | yxeP_1 | Putative hydrolase YxeP. (414 aa) |
| | T45_01043 | Citrate synthase. (271 aa) |
| | yvoA_1 | HTH-type transcriptional repressor YvoA. (262 aa) |
| | dapC | Putative N-succinyldiaminopimelate. (394 aa) |
| | fba | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa) |
| | ask | Aspartokinase; Belongs to the aspartokinase family. (426 aa) |
| | asd_2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (364 aa) |
| | T45_00836 | FR47-like protein. (286 aa) |
| | vapC-2 | Ribonuclease VapC21; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (135 aa) |
| | yurK_2 | Putative HTH-type transcriptional regulator. (271 aa) |
| | T45_00766 | Haloacid dehalogenase-like hydrolase. (277 aa) |
| | vapC | Ribonuclease VapC21; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (139 aa) |
| | T45_00723 | Phosphotransferase enzyme family protein. (326 aa) |
| | gmuR_2 | HTH-type transcriptional regulator GmuR. (77 aa) |
| | asd_1 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | rpiB_1 | Ribose-5-phosphate isomerase B. (161 aa) |
| | yurK_1 | Putative HTH-type transcriptional regulator. (259 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa) |
| | proA_1 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (428 aa) |
| | gpgP | Glucosyl-3-phosphoglycerate phosphatase; Belongs to the phosphoglycerate mutase family. (224 aa) |
| | gmuR_1 | HTH-type transcriptional regulator GmuR. (95 aa) |
| | leuA_1 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (576 aa) |
| | yagE | Putative 2-keto-3-deoxy-galactonate aldolase; Belongs to the DapA family. (311 aa) |
| | puuA | Gamma-glutamylputrescine synthetase PuuA; Belongs to the glutamine synthetase family. (461 aa) |
| | rsmA_1 | Ribosomal RNA small subunit methyltransferase A; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (202 aa) |
| | T45_00227 | Acetylornithine deacetylase. (86 aa) |
| | T45_00210 | Hypothetical protein. (793 aa) |
| | cobD_1 | Threonine-phosphate decarboxylase. (583 aa) |
| | tal_1 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (389 aa) |
| | aroH_1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (392 aa) |
| | aroC_1 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
