STRINGSTRING
AEF98501.1 AEF98501.1 thyX thyX AEF98503.1 AEF98503.1 AEF98524.1 AEF98524.1 AEF98566.1 AEF98566.1 pyrB pyrB AEF98568.1 AEF98568.1 pyrF pyrF pyrD pyrD pyrH pyrH AEG00066.1 AEG00066.1 AEG00221.1 AEG00221.1 AEG00256.1 AEG00256.1 cmk cmk ppnP ppnP AEG01076.1 AEG01076.1 AEG01157.1 AEG01157.1 AEG01495.1 AEG01495.1 AEG01496.1 AEG01496.1 AEG01588.1 AEG01588.1 AEG01592.1 AEG01592.1 carB carB carA carA dut dut pyrG pyrG tmk tmk pyrC pyrC ndk ndk surE surE AEG02648.1 AEG02648.1 AEG02686.1 AEG02686.1 dcd dcd thyA thyA pyrE pyrE AEG02932.1 AEG02932.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Your Input:
AEF98501.1Hypothetical protein; KEGG: sma:SAV_4464 deoxycytidine triphosphate deaminase. (278 aa)
thyXThymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (268 aa)
AEF98503.1PfkB domain protein; PFAM: Carbohydrate/purine kinase; KEGG: mem:Memar_0859 ribokinase-like domain-containing protein. (310 aa)
AEF98524.1PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: csh:Closa_1075 cytidine deaminase. (155 aa)
AEF98566.1Dihydroorotase, multifunctional complex type; KEGG: mca:MCA2332 dihydroorotase family protein; TIGRFAM: Dihydroorotase multifunctional complex type; PFAM: Amidohydrolase 3. (428 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: mca:MCA2333 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (321 aa)
AEF98568.1Uracil phosphoribosyltransferase; KEGG: mca:MCA2334 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; PFAM: Phosphoribosyltransferase. (172 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (241 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (337 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
AEG00066.15'-nucleotidase; KEGG: tbd:Tbd_0356 5'-nucleotidase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; Belongs to the 5'-nucleotidase family. (612 aa)
AEG00221.1PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: hch:HCH_03679 hypothetical protein; SMART: Metal-dependent phosphohydrolase, HD region. (201 aa)
AEG00256.1KEGG: mca:MCA0046 MazG family protein; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core. (272 aa)
cmkPFAM: Cytidylate kinase region; TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: mca:MCA1414 cytidylate kinase. (218 aa)
ppnPUPF0345 protein yaiE; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (103 aa)
AEG01076.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (716 aa)
AEG01157.1Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (337 aa)
AEG01495.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (930 aa)
AEG01496.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (387 aa)
AEG01588.1TIGRFAM: Amidase, hydantoinase/carbamoylase; KEGG: tgr:Tgr7_0180 allantoate amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (415 aa)
AEG01592.1KEGG: nhl:Nhal_2221 aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain protein; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (352 aa)
carBTIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: mca:MCA1852 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Belongs to the CarB family. (1073 aa)
carATIGRFAM: Carbamoyl phosphate synthase, small subunit; KEGG: tau:Tola_1026 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (377 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (207 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (359 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa)
AEG02648.15'-nucleotidase; KEGG: ppw:PputW619_2065 5'-nucleotidase; PFAM: 5-nucleotidase. (308 aa)
AEG02686.1KEGG: mca:MCA2982 HAD superfamily hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase. (222 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (212 aa)
AEG02932.1PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: xcb:XC_0670 cytosine deaminase. (149 aa)
Your Current Organism:
Methylomonas methanica
NCBI taxonomy Id: 857087
Other names: M. methanica MC09, Methylomonas methanica MC09, Methylomonas methanica str. MC09, Methylomonas methanica strain MC09
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