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AEF16076.1 AEF16076.1 ilvC ilvC AEF16078.1 AEF16078.1 leuC leuC leuD leuD leuB leuB ilvD ilvD AEF16083.1 AEF16083.1 AEF16125.1 AEF16125.1 AEF16126.1 AEF16126.1 AEF16129.1 AEF16129.1 AEF16130.1 AEF16130.1 AEF16275.1 AEF16275.1 AEF16297.1 AEF16297.1 AEF16353.1 AEF16353.1 AEF16428.1 AEF16428.1 AEF16442.1 AEF16442.1 AEF16443.1 AEF16443.1 AEF16444.1 AEF16444.1 AEF16445.1 AEF16445.1 AEF16446.1 AEF16446.1 AEF16817.1 AEF16817.1 AEF16852.1 AEF16852.1 AEF16887.1 AEF16887.1 pckA pckA AEF16889.1 AEF16889.1 AEF17047.1 AEF17047.1 AEF17137.1 AEF17137.1 AEF17261.1 AEF17261.1 AEF17289.1 AEF17289.1 ackA ackA AEF17402.1 AEF17402.1 ilvE ilvE AEF17645.1 AEF17645.1 AEF17646.1 AEF17646.1 AEF17647.1 AEF17647.1 AEF17648.1 AEF17648.1 AEF17649.1 AEF17649.1 AEF17650.1 AEF17650.1 AEF17651.1 AEF17651.1 AEF17652.1 AEF17652.1 AEF17653.1 AEF17653.1 AEF17654.1 AEF17654.1 AEF17659.1 AEF17659.1 AEF17660.1 AEF17660.1 AEF17661.1 AEF17661.1 AEF17662.1 AEF17662.1 buk buk AEF17664.1 AEF17664.1 AEF17665.1 AEF17665.1 AEF17745.1 AEF17745.1 AEF17944.1 AEF17944.1 AEF17945.1 AEF17945.1 AEF17961.1 AEF17961.1 AEF17962.1 AEF17962.1 AEF17963.1 AEF17963.1 ldh ldh AEF18105.1 AEF18105.1 AEF18214.1 AEF18214.1 AEF18269.1 AEF18269.1 AEF18270.1 AEF18270.1 AEF18317.1 AEF18317.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
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AEF16076.1Manually curated; TIGRFAM: Acetolactate synthase, small subunit; KEGG: ttm:Tthe_0012 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (168 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
AEF16078.12-isopropylmalate synthase; KEGG: ttm:Tthe_0014 pyruvate carboxyltransferase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (397 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa)
ilvDPFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: ttm:Tthe_0018 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa)
AEF16083.1TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: ttm:Tthe_0019 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (551 aa)
AEF16125.1TIGRFAM: Formate acetyltransferase; KEGG: gmc:GY4MC1_3791 formate acetyltransferase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical. (742 aa)
AEF16126.1Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (242 aa)
AEF16129.1TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; KEGG: ttm:Tthe_0069 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain. (280 aa)
AEF16130.1TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; KEGG: ttm:Tthe_0070 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain. (185 aa)
AEF16275.1Aspartate ammonia-lyase; KEGG: ttm:Tthe_0255 fumarate lyase; PFAM: Lyase 1, N-terminal; Fumarase C, C-terminal. (471 aa)
AEF16297.1SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_0338 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1172 aa)
AEF16353.1Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; KEGG: ttm:Tthe_0395 malic protein NAD-binding; SMART: Malic enzyme, NAD-binding. (405 aa)
AEF16428.1Alcohol dehydrogenase; KEGG: ttm:Tthe_0472 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (393 aa)
AEF16442.1KEGG: ttm:Tthe_0486 hypothetical protein. (224 aa)
AEF16443.1PFAM: 4Fe-4S binding domain; KEGG: ttm:Tthe_0487 4Fe-4S ferredoxin iron-sulfur binding domain protein. (76 aa)
AEF16444.13-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: ttm:Tthe_0488 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal. (354 aa)
AEF16445.12-oxoglutarate synthase; KEGG: ttm:Tthe_0489 thiamine pyrophosphate protein domain protein TPP-binding; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (249 aa)
AEF16446.1KEGG: ttm:Tthe_0490 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (183 aa)
AEF16817.1SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase-related; KEGG: ttm:Tthe_2053 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (519 aa)
AEF16852.1Acylphosphatase; KEGG: ttm:Tthe_2024 acylphosphatase; HAMAP: Acylphosphatase; PFAM: Acylphosphatase-like. (90 aa)
AEF16887.1PFAM: Asparaginase/glutaminase; KEGG: thx:Thet_1569 asparaginase/glutaminase; SMART: Asparaginase/glutaminase. (330 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (509 aa)
AEF16889.1KEGG: tte:TTE1368 aspartate aminotransferase; PFAM: Aminotransferase, class I/classII. (396 aa)
AEF17047.1TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; KEGG: ttm:Tthe_1815 asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (613 aa)
AEF17137.1Cyclase family protein; PFAM: Putative cyclase; KEGG: ttm:Tthe_1639 arylformamidase. (209 aa)
AEF17261.1Pyruvate carboxylase; KEGG: ttm:Tthe_1352 conserved carboxylase region; PFAM: Carboxylase, conserved domain; Pyruvate carboxyltransferase. (464 aa)
AEF17289.1Aspartate transaminase; KEGG: ttm:Tthe_1380 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (395 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
AEF17402.1TIGRFAM: Phosphate acetyltransferase; KEGG: ttm:Tthe_1502 phosphate acetyltransferase; PFAM: Phosphate acetyl/butaryl transferase. (328 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa)
AEF17645.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: tpd:Teth39_1152 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (184 aa)
AEF17646.1KEGG: tpd:Teth39_1151 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (277 aa)
AEF17647.1KEGG: tpd:Teth39_1150 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (374 aa)
AEF17648.1PFAM: 4Fe-4S binding domain; KEGG: thx:Thet_1316 4Fe-4S ferredoxin iron-sulfur-binding domain-containing protein. (73 aa)
AEF17649.1Sodium ion-translocating decarboxylase, beta subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (374 aa)
AEF17650.1Hypothetical protein. (48 aa)
AEF17651.1methylmalonyl-CoA epimerase; KEGG: tte:TTE1219 lactoylglutathione lyase and related lyase; TIGRFAM: Methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (132 aa)
AEF17652.1LAO/AO transport system ATPase; TIGRFAM: ArgK protein; PFAM: ArgK protein; KEGG: tte:TTE2387 periplasmic protein kinase ArgK; SMART: ATPase, AAA+ type, core. (316 aa)
AEF17653.1KEGG: tte:TTE2388 methylmalonyl-CoA mutase C-terminal domain-containing protein; TIGRFAM: Methylmalonyl-CoA mutase, C-terminal; PFAM: Cobalamin (vitamin B12)-binding. (131 aa)
AEF17654.1TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; KEGG: toc:Toce_1200 methylmalonyl-CoA mutase; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic. (559 aa)
AEF17659.1KEGG: tpd:Teth39_0467 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (183 aa)
AEF17660.12-oxoglutarate synthase; KEGG: ttm:Tthe_0489 thiamine pyrophosphate protein domain protein TPP-binding; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (249 aa)
AEF17661.13-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: ttm:Tthe_0488 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal. (354 aa)
AEF17662.1PFAM: 4Fe-4S binding domain; KEGG: ttm:Tthe_0487 4Fe-4S ferredoxin iron-sulfur binding domain protein. (76 aa)
bukPFAM: Acetate/butyrate kinase; TIGRFAM: Butyrate kinase; HAMAP: butyrate kinase; KEGG: tpd:Teth39_0462 butyrate kinase; Belongs to the acetokinase family. (355 aa)
AEF17664.1PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; KEGG: tpd:Teth39_0461 Glu/Leu/Phe/Val dehydrogenase, dimerisation region; SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal. (356 aa)
AEF17665.1TIGRFAM: Phosphate butyryltransferase; KEGG: tmt:Tmath_1880 phosphate butyryltransferase; PFAM: Phosphate acetyl/butaryl transferase. (301 aa)
AEF17745.1PFAM: 4-oxalocrotonate tautomerase; KEGG: ttm:Tthe_1010 4-oxalocrotonate tautomerase. (116 aa)
AEF17944.1Aconitate hydratase; TIGRFAM: Aconitase, putative; 3-isopropylmalate dehydratase, small subunit, subgroup; KEGG: ttm:Tthe_2228 aconitate hydratase; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel. (640 aa)
AEF17945.1TIGRFAM: Homocitrate synthase NifV-type; KEGG: ttm:Tthe_2229 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa)
AEF17961.1KEGG: ttm:Tthe_2242 hypothetical protein. (622 aa)
AEF17962.1SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_2243 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1175 aa)
AEF17963.1KEGG: ttm:Tthe_2244 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, eukaryotic; PFAM: Isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (311 aa)
AEF18105.1Acetaldehyde dehydrogenase (acetylating); KEGG: cpy:Cphy_1178 aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase domain. (467 aa)
AEF18214.1KEGG: ttm:Tthe_2544 thiamine biosynthesis Thi4 protein. (637 aa)
AEF18269.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: ttm:Tthe_2603 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (562 aa)
AEF18270.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: ttm:Tthe_2604 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (282 aa)
AEF18317.1Acetaldehyde dehydrogenase (acetylating); KEGG: ttm:Tthe_2646 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; Aldehyde dehydrogenase domain. (859 aa)
Your Current Organism:
Thermoanaerobacterium xylanolyticum
NCBI taxonomy Id: 858215
Other names: T. xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum DSM 7097, Thermoanaerobacterium xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum str. LX-11, Thermoanaerobacterium xylanolyticum strain LX-11
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