STRINGSTRING
AEF16076.1 AEF16076.1 ilvC ilvC AEF16078.1 AEF16078.1 leuC leuC leuD leuD leuB leuB ilvD ilvD AEF16083.1 AEF16083.1 AEF16297.1 AEF16297.1 AEF16442.1 AEF16442.1 AEF16443.1 AEF16443.1 AEF16444.1 AEF16444.1 AEF16445.1 AEF16445.1 AEF16446.1 AEF16446.1 AEF16817.1 AEF16817.1 AEF17261.1 AEF17261.1 ilvE ilvE AEF17646.1 AEF17646.1 AEF17647.1 AEF17647.1 AEF17649.1 AEF17649.1 AEF17659.1 AEF17659.1 AEF17660.1 AEF17660.1 AEF17661.1 AEF17661.1 AEF17662.1 AEF17662.1 AEF17664.1 AEF17664.1 AEF17945.1 AEF17945.1 AEF17962.1 AEF17962.1 ldh ldh AEF18269.1 AEF18269.1 AEF18270.1 AEF18270.1 AEF18317.1 AEF18317.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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AEF16076.1Manually curated; TIGRFAM: Acetolactate synthase, small subunit; KEGG: ttm:Tthe_0012 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (168 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
AEF16078.12-isopropylmalate synthase; KEGG: ttm:Tthe_0014 pyruvate carboxyltransferase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (397 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa)
ilvDPFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: ttm:Tthe_0018 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa)
AEF16083.1TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: ttm:Tthe_0019 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (551 aa)
AEF16297.1SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_0338 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1172 aa)
AEF16442.1KEGG: ttm:Tthe_0486 hypothetical protein. (224 aa)
AEF16443.1PFAM: 4Fe-4S binding domain; KEGG: ttm:Tthe_0487 4Fe-4S ferredoxin iron-sulfur binding domain protein. (76 aa)
AEF16444.13-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: ttm:Tthe_0488 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal. (354 aa)
AEF16445.12-oxoglutarate synthase; KEGG: ttm:Tthe_0489 thiamine pyrophosphate protein domain protein TPP-binding; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (249 aa)
AEF16446.1KEGG: ttm:Tthe_0490 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (183 aa)
AEF16817.1SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase-related; KEGG: ttm:Tthe_2053 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (519 aa)
AEF17261.1Pyruvate carboxylase; KEGG: ttm:Tthe_1352 conserved carboxylase region; PFAM: Carboxylase, conserved domain; Pyruvate carboxyltransferase. (464 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa)
AEF17646.1KEGG: tpd:Teth39_1151 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (277 aa)
AEF17647.1KEGG: tpd:Teth39_1150 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (374 aa)
AEF17649.1Sodium ion-translocating decarboxylase, beta subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (374 aa)
AEF17659.1KEGG: tpd:Teth39_0467 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (183 aa)
AEF17660.12-oxoglutarate synthase; KEGG: ttm:Tthe_0489 thiamine pyrophosphate protein domain protein TPP-binding; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (249 aa)
AEF17661.13-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: ttm:Tthe_0488 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal. (354 aa)
AEF17662.1PFAM: 4Fe-4S binding domain; KEGG: ttm:Tthe_0487 4Fe-4S ferredoxin iron-sulfur binding domain protein. (76 aa)
AEF17664.1PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; KEGG: tpd:Teth39_0461 Glu/Leu/Phe/Val dehydrogenase, dimerisation region; SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal. (356 aa)
AEF17945.1TIGRFAM: Homocitrate synthase NifV-type; KEGG: ttm:Tthe_2229 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa)
AEF17962.1SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_2243 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1175 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (311 aa)
AEF18269.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: ttm:Tthe_2603 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (562 aa)
AEF18270.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: ttm:Tthe_2604 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (282 aa)
AEF18317.1Acetaldehyde dehydrogenase (acetylating); KEGG: ttm:Tthe_2646 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; Aldehyde dehydrogenase domain. (859 aa)
Your Current Organism:
Thermoanaerobacterium xylanolyticum
NCBI taxonomy Id: 858215
Other names: T. xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum DSM 7097, Thermoanaerobacterium xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum str. LX-11, Thermoanaerobacterium xylanolyticum strain LX-11
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