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AEF16076.1 | Manually curated; TIGRFAM: Acetolactate synthase, small subunit; KEGG: ttm:Tthe_0012 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (168 aa) | ||||
ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) | ||||
AEF16078.1 | 2-isopropylmalate synthase; KEGG: ttm:Tthe_0014 pyruvate carboxyltransferase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (397 aa) | ||||
leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) | ||||
leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) | ||||
leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) | ||||
ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: ttm:Tthe_0018 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa) | ||||
AEF16083.1 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: ttm:Tthe_0019 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (551 aa) | ||||
AEF16297.1 | SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_0338 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1172 aa) | ||||
AEF16817.1 | SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase-related; KEGG: ttm:Tthe_2053 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (519 aa) | ||||
AEF17261.1 | Pyruvate carboxylase; KEGG: ttm:Tthe_1352 conserved carboxylase region; PFAM: Carboxylase, conserved domain; Pyruvate carboxyltransferase. (464 aa) | ||||
ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa) | ||||
AEF17646.1 | KEGG: tpd:Teth39_1151 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (277 aa) | ||||
AEF17647.1 | KEGG: tpd:Teth39_1150 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (374 aa) | ||||
AEF17649.1 | Sodium ion-translocating decarboxylase, beta subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (374 aa) | ||||
AEF17664.1 | PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; KEGG: tpd:Teth39_0461 Glu/Leu/Phe/Val dehydrogenase, dimerisation region; SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal. (356 aa) | ||||
AEF17945.1 | TIGRFAM: Homocitrate synthase NifV-type; KEGG: ttm:Tthe_2229 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa) | ||||
AEF17962.1 | SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_2243 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1175 aa) | ||||
ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (311 aa) | ||||
AEF18269.1 | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: ttm:Tthe_2603 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (562 aa) | ||||
AEF18270.1 | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: ttm:Tthe_2604 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (282 aa) | ||||
AEF18317.1 | Acetaldehyde dehydrogenase (acetylating); KEGG: ttm:Tthe_2646 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; Aldehyde dehydrogenase domain. (859 aa) |