STRINGSTRING
AEF17540.1 AEF17540.1 leuC leuC AEF16126.1 AEF16126.1 AEF16129.1 AEF16129.1 AEF16131.1 AEF16131.1 AEF16171.1 AEF16171.1 AEF16174.1 AEF16174.1 AEF16297.1 AEF16297.1 AEF16479.1 AEF16479.1 nadA nadA AEF16564.1 AEF16564.1 AEF16689.1 AEF16689.1 purF purF AEF16818.1 AEF16818.1 AEF16824.1 AEF16824.1 nth nth AEF16919.1 AEF16919.1 AEF17067.1 AEF17067.1 AEF17079.1 AEF17079.1 AEF17140.1 AEF17140.1 AEF17141.1 AEF17141.1 AEF17170.1 AEF17170.1 ispH ispH miaB miaB rimO rimO ispG ispG AEF17389.1 AEF17389.1 rlmN rlmN AEF17456.1 AEF17456.1 AEF17547.1 AEF17547.1 AEF17570.1 AEF17570.1 AEF17584.1 AEF17584.1 AEF17611.1 AEF17611.1 AEF17612.1 AEF17612.1 AEF17618.1 AEF17618.1 thiC thiC AEF17858.1 AEF17858.1 AEF17890.1 AEF17890.1 AEF17962.1 AEF17962.1 AEF18097.1 AEF18097.1 hcp hcp
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AEF17540.1RNA modification enzyme, MiaB family; TIGRFAM: Methylthiotransferase; MiaB-like tRNA modifying enzyme; PFAM: Methylthiotransferase, N-terminal; Radical SAM; KEGG: ttm:Tthe_1190 MiaB-like protein tRNA modifying enzyme; SMART: Elongator protein 3/MiaB/NifB. (467 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
AEF16126.1Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (242 aa)
AEF16129.1TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; KEGG: ttm:Tthe_0069 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain. (280 aa)
AEF16131.1KEGG: ttm:Tthe_0071 phage SPO1 DNA polymerase-related protein; TIGRFAM: Phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase-like. (187 aa)
AEF16171.1NADH dehydrogenase (quinone); KEGG: ttm:Tthe_0120 NADH ubiquinone oxidoreductase 20 kDa subunit; PFAM: NADH:ubiquinone oxidoreductase-like, 20kDa subunit. (157 aa)
AEF16174.1PFAM: 4Fe-4S binding domain; KEGG: ttm:Tthe_0123 4Fe-4S ferredoxin iron-sulfur binding domain protein. (118 aa)
AEF16297.1SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_0338 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1172 aa)
AEF16479.1PFAM: Protein of unknown function DUF2148; KEGG: ttm:Tthe_0545 protein of unknown function DUF2148. (171 aa)
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa)
AEF16564.1KEGG: ttm:Tthe_0617 glutamate synthase (NADPH); PFAM: Glutamate synthase, central-C; 4Fe-4S binding domain. (501 aa)
AEF16689.1KEGG: ttm:Tthe_0774 RNA methyltransferase, TrmA family; TIGRFAM: 23S rRNA methyltransferase/RumA; PFAM: (Uracil-5)-methyltransferase; Deoxyribonuclease/rho motif-related TRAM; Methyltransferase type 11; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (453 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (465 aa)
AEF16818.1ATP-dependent nuclease subunit B-like protein; ATP-dependent DNA helicase. (1036 aa)
AEF16824.1PFAM: Radical SAM; KEGG: ttm:Tthe_2046 radical SAM domain protein. (297 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (214 aa)
AEF16919.1KEGG: aoe:Clos_1718 radical SAM domain-containing protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (453 aa)
AEF17067.1KEGG: thx:Thet_0893 DegS sensor signal transduction histidine kinase; PFAM: Sensor DegS; Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain; ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain. (382 aa)
AEF17079.1PFAM: Iron hydrogenase, large subunit, C-terminal; 4Fe-4S binding domain; Putative Fe-S cluster; KEGG: ttm:Tthe_1784 putative PAS/PAC sensor protein. (572 aa)
AEF17140.1TIGRFAM: Iron-sulphur-dependent L-serine dehydratase beta subunit; KEGG: ttm:Tthe_1636 L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: Serine dehydratase beta chain; Amino acid-binding ACT. (228 aa)
AEF17141.1TIGRFAM: Serine dehydratase, alpha subunit; KEGG: ttm:Tthe_1635 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: Serine dehydratase-like, alpha subunit. (291 aa)
AEF17170.1KEGG: ttm:Tthe_1606 radical SAM domain protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (326 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (283 aa)
miaB(Dimethylallyl)adenosine tRNA methylthiotransferase miaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (473 aa)
rimORibosomal protein S12 methylthiotransferase rimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (437 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (354 aa)
AEF17389.1KEGG: thx:Thet_1181 radical SAM domain-containing protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (354 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (343 aa)
AEF17456.1PFAM: Radical SAM; KEGG: ttm:Tthe_1558 radical SAM domain protein. (459 aa)
AEF17547.1Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa)
AEF17570.14Fe-4S ferredoxin iron-sulfur binding domain-containing protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (56 aa)
AEF17584.1PFAM: Domain of unknown function DUF362; 4Fe-4S binding domain; KEGG: ttm:Tthe_1147 protein of unknown function DUF362. (378 aa)
AEF17611.1SMART: Iron hydrogenase, small subunit-like; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; TIGRFAM: Iron hydrogenase, subset; KEGG: ttm:Tthe_1120 hydrogenase, Fe-only; PFAM: Iron hydrogenase, large subunit, C-terminal; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; 4Fe-4S binding domain; Iron hydrogenase, small subunit-like. (581 aa)
AEF17612.1NADH dehydrogenase (quinone); PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Sucraseferredoxin-like; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S binding domain; KEGG: ttm:Tthe_1119 NADH dehydrogenase (quinone); SMART: NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding. (596 aa)
AEF17618.1PFAM: Putative Fe-S cluster; 4Fe-4S binding domain; KEGG: ttm:Tthe_1113 Fe-S cluster domain protein. (436 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (434 aa)
AEF17858.1KEGG: ttm:Tthe_0853 RNA methyltransferase, TrmA family; TIGRFAM: 23S rRNA methyltransferase/RumA; PFAM: (Uracil-5)-methyltransferase; Methyltransferase small; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (452 aa)
AEF17890.1KEGG: ttm:Tthe_2184 hypothetical protein. (244 aa)
AEF17962.1SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_2243 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1175 aa)
AEF18097.1PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Soluble ligand binding domain; KEGG: cbt:CLH_1845 ethanolamine utilization Fe-S center protein eut. (455 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (546 aa)
Your Current Organism:
Thermoanaerobacterium xylanolyticum
NCBI taxonomy Id: 858215
Other names: T. xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum DSM 7097, Thermoanaerobacterium xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum str. LX-11, Thermoanaerobacterium xylanolyticum strain LX-11
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