STRINGSTRING
dnaA dnaA dnaX dnaX AEF16155.1 AEF16155.1 AEF16167.1 AEF16167.1 ftsH ftsH AEF16358.1 AEF16358.1 radA radA ecfA ecfA ecfA-2 ecfA-2 AEF16537.1 AEF16537.1 ftsH-2 ftsH-2 AEF16553.1 AEF16553.1 AEF16560.1 AEF16560.1 ftsE ftsE uvrA uvrA AEF16579.1 AEF16579.1 AEF16593.1 AEF16593.1 AEF16603.1 AEF16603.1 AEF16700.1 AEF16700.1 AEF16721.1 AEF16721.1 AEF16735.1 AEF16735.1 AEF16736.1 AEF16736.1 AEF16742.1 AEF16742.1 metN metN AEF16786.1 AEF16786.1 AEF16787.1 AEF16787.1 AEF16835.1 AEF16835.1 AEF16915.1 AEF16915.1 AEF16985.1 AEF16985.1 AEF17019.1 AEF17019.1 pstB pstB AEF17188.1 AEF17188.1 AEF17189.1 AEF17189.1 AEF17208.1 AEF17208.1 AEF17286.1 AEF17286.1 recA recA AEF17304.1 AEF17304.1 AEF17345.1 AEF17345.1 AEF17362.1 AEF17362.1 hslU hslU AEF17377.1 AEF17377.1 ffh ffh ftsY ftsY ruvB ruvB AEF17484.1 AEF17484.1 AEF17563.1 AEF17563.1 AEF17652.1 AEF17652.1 AEF17748.1 AEF17748.1 AEF17785.1 AEF17785.1 AEF17836.1 AEF17836.1 atpD atpD lon lon clpX clpX recD2 recD2 AEF17957.1 AEF17957.1 AEF17982.1 AEF17982.1 AEF18004.1 AEF18004.1 AEF18016.1 AEF18016.1 AEF18036.1 AEF18036.1 AEF18130.1 AEF18130.1 AEF18136.1 AEF18136.1 rho rho AEF18215.1 AEF18215.1 AEF18216.1 AEF18216.1 AEF18271.1 AEF18271.1 AEF18272.1 AEF18272.1 AEF18298.1 AEF18298.1 AEF18340.1 AEF18340.1 AEF18364.1 AEF18364.1 AEF18366.1 AEF18366.1 AEF18380.1 AEF18380.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaAChromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (443 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (530 aa)
AEF16155.1KEGG: ttm:Tthe_0095 ABC transporter related; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core. (231 aa)
AEF16167.1PFAM: ATPase, AAA-type, core; Peptidase M41; KEGG: ttm:Tthe_0117 vesicle-fusing ATPase; SMART: ATPase, AAA+ type, core. (494 aa)
ftsHATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (611 aa)
AEF16358.1KEGG: ttm:Tthe_0400 ATPase AAA-2 domain protein; PFAM: ATPase, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; Belongs to the ClpA/ClpB family. (810 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (448 aa)
ecfAPolyamine-transporting ATPase; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (281 aa)
ecfA-2Sulfate-transporting ATPase; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (285 aa)
AEF16537.1Putative sigma54 specific transcriptional regulator; TIGRFAM: PAS; PFAM: RNA polymerase sigma factor 54, interaction; PAS fold; KEGG: ttm:Tthe_0590 putative sigma54 specific transcriptional regulator; SMART: ATPase, AAA+ type, core; PAS. (546 aa)
ftsH-2ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (506 aa)
AEF16553.1Sulfate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_0607 ABC transporter related; SMART: ATPase, AAA+ type, core. (327 aa)
AEF16560.1Glycerol-3-phosphate-transporting ATPase; PFAM: ABC transporter-like; Transport-associated OB, type 1; KEGG: ttm:Tthe_0613 ABC transporter related; SMART: ATPase, AAA+ type, core. (371 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (228 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (926 aa)
AEF16579.1Taurine-transporting ATPase; PFAM: ABC transporter-like; KEGG: toc:Toce_1611 ABC transporter related protein; SMART: ATPase, AAA+ type, core. (256 aa)
AEF16593.1KEGG: ttm:Tthe_0646 PTS system transcriptional activator; PFAM: RNA polymerase sigma factor 54, interaction; PRD; Phosphotransferase system, fructose subfamily IIA component; SMART: ATPase, AAA+ type, core. (906 aa)
AEF16603.1Monosaccharide-transporting ATPase; PFAM: ABC transporter-like; KEGG: ssm:Spirs_0835 ABC transporter related protein; SMART: ATPase, AAA+ type, core. (498 aa)
AEF16700.1Sulfate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2174 ABC transporter related; SMART: ATPase, AAA+ type, core. (240 aa)
AEF16721.1KEGG: ttm:Tthe_2153 ABC transporter related; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core. (630 aa)
AEF16735.1Phosphonate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2132 ABC transporter related; SMART: ATPase, AAA+ type, core. (233 aa)
AEF16736.1Sulfate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2131 ABC transporter related; SMART: ATPase, AAA+ type, core. (266 aa)
AEF16742.1Phosphonate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2125 ABC transporter related; SMART: ATPase, AAA+ type, core. (263 aa)
metNPhosphonate-transporting ATPase; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (340 aa)
AEF16786.1SMART: ATPase, AAA+ type, core; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; KEGG: ttm:Tthe_2082 oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter-like; Oligopeptide/dipeptide ABC transporter, C-terminal. (344 aa)
AEF16787.1SMART: ATPase, AAA+ type, core; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; KEGG: ttm:Tthe_2081 oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter-like; Oligopeptide/dipeptide ABC transporter, C-terminal. (319 aa)
AEF16835.1KEGG: ttm:Tthe_2473 PTS system transcriptional activator; PFAM: RNA polymerase sigma factor 54, interaction; PRD; Phosphotransferase system, fructose subfamily IIA component; SMART: ATPase, AAA+ type, core. (884 aa)
AEF16915.1Phosphonate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_0470 ABC transporter related; SMART: ATPase, AAA+ type, core. (230 aa)
AEF16985.1KEGG: thx:Thet_0156 PTS system transcriptional activator; PFAM: RNA polymerase sigma factor 54, interaction; PRD; Phosphotransferase system, fructose subfamily IIA component; Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2; SMART: ATPase, AAA+ type, core. (975 aa)
AEF17019.1SMART: ATPase, AAA+ type, core; TIGRFAM: ABC transporter, gallidermin, ATP-binding subunit; KEGG: ttm:Tthe_1886 ABC transporter related; PFAM: ABC transporter-like. (232 aa)
pstBPhosphate ABC transporter, ATPase subunit; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (249 aa)
AEF17188.1KEGG: ttm:Tthe_1277 type II secretion system protein E; PFAM: Type II secretion system protein E; General secretory system II, protein E, N-terminal; SMART: ATPase, AAA+ type, core. (564 aa)
AEF17189.1Twitching motility protein; TIGRFAM: Pilus retraction protein PilT; PFAM: Type II secretion system protein E; KEGG: ttm:Tthe_1278 twitching motility protein; SMART: ATPase, AAA+ type, core. (350 aa)
AEF17208.1KEGG: ttm:Tthe_1297 stage III sporulation protein AA; TIGRFAM: Sporulation stage III, protein AA; SMART: ATPase, AAA+ type, core. (334 aa)
AEF17286.1TIGRFAM: Sporulation stage V, protein K; PFAM: ATPase, AAA-type, core; KEGG: ttm:Tthe_1377 stage V sporulation protein K; SMART: ATPase, AAA+ type, core. (296 aa)
recAProtein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (343 aa)
AEF17304.1KEGG: ttm:Tthe_1395 cell divisionFtsK/SpoIIIE; PFAM: Cell divisionFtsK/SpoIIIE; DNA translocase FtsK gamma; SMART: DNA translocase FtsK gamma; ATPase, AAA+ type, core. (724 aa)
AEF17345.1Flagellar biosynthetic protein FlhF; TIGRFAM: Signal-recognition particle (SRP)-type GTPase; PFAM: Signal recognition particle, SRP54 subunit, GTPase; KEGG: ttm:Tthe_1435 flagellar biosynthetic protein FlhF; SMART: Signal recognition particle, SRP54 subunit, GTPase; ATPase, AAA+ type, core. (337 aa)
AEF17362.1SMART: ATPase, AAA+ type, core; TIGRFAM: Flagellar export ATPase, FliI, clade 2; ATPase, type III secretion system, FliI/YscN; KEGG: ttm:Tthe_1452 ATPase, FliI/YscN family; PFAM: ATPase, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal. (438 aa)
hslUATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (460 aa)
AEF17377.1Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein; PFAM: Magnesium chelatase, ChlI subunit; KEGG: ttm:Tthe_1467 Mg chelatase, subunit ChlI; SMART: ATPase, AAA+ type, core. (510 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (446 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (321 aa)
ruvBHolliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (331 aa)
AEF17484.1KEGG: ttm:Tthe_1253 AAA ATPase central domain protein; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core. (442 aa)
AEF17563.1Sulfate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_1166 ABC transporter related; SMART: ATPase, AAA+ type, core. (266 aa)
AEF17652.1LAO/AO transport system ATPase; TIGRFAM: ArgK protein; PFAM: ArgK protein; KEGG: tte:TTE2387 periplasmic protein kinase ArgK; SMART: ATPase, AAA+ type, core. (316 aa)
AEF17748.1Phosphonate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_1006 ABC transporter related; SMART: ATPase, AAA+ type, core. (234 aa)
AEF17785.1ATPase associated with various cellular activities AAA_5; KEGG: mpd:MCP_0968 hypothetical protein; PFAM: ATPase, AAA-5; SMART: ATPase, AAA+ type, core. (759 aa)
AEF17836.1Taurine-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_0901 ABC transporter related; SMART: ATPase, AAA+ type, core. (244 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (461 aa)
lonAnti-sigma H sporulation factor, LonB; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (774 aa)
clpXATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
recD2Helicase, RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (762 aa)
AEF17957.1Monosaccharide-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2238 ABC transporter related; SMART: ATPase, AAA+ type, core. (508 aa)
AEF17982.1Iron-chelate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2264 ABC transporter related; SMART: ATPase, AAA+ type, core. (266 aa)
AEF18004.1Phosphonate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2305 ABC transporter related; SMART: ATPase, AAA+ type, core. (257 aa)
AEF18016.1KEGG: ttm:Tthe_2359 PTS system transcriptional activator; PFAM: RNA polymerase sigma factor 54, interaction; Double-stranded RNA-specific adenosine deaminase (DRADA); PRD; Phosphotransferase system, fructose subfamily IIA component; SMART: ATPase, AAA+ type, core. (900 aa)
AEF18036.1Monosaccharide-transporting ATPase; PFAM: ABC transporter-like; KEGG: cst:CLOST_0543 fused D-xylose transporter subunits of ABC superfamily: ATP-binding components; SMART: ATPase, AAA+ type, core. (508 aa)
AEF18130.1Sulfate-transporting ATPase; PFAM: ABC transporter-like; KEGG: cce:Ccel_2159 ABC transporter related; SMART: ATPase, AAA+ type, core. (291 aa)
AEF18136.1Sulfate-transporting ATPase; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2452 ABC transporter related; SMART: ATPase, AAA+ type, core. (244 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (613 aa)
AEF18215.1Xenobiotic-transporting ATPase; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; KEGG: ttm:Tthe_2546 ABC transporter related; SMART: ATPase, AAA+ type, core. (594 aa)
AEF18216.1Xenobiotic-transporting ATPase; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; KEGG: ttm:Tthe_2547 ABC transporter related; SMART: ATPase, AAA+ type, core. (582 aa)
AEF18271.1Xenobiotic-transporting ATPase; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; KEGG: ttm:Tthe_2605 ABC transporter related; SMART: ATPase, AAA+ type, core. (623 aa)
AEF18272.1Xenobiotic-transporting ATPase; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; KEGG: ttm:Tthe_2606 ABC transporter related; SMART: ATPase, AAA+ type, core. (741 aa)
AEF18298.1TIGRFAM: ATPase SufC, SUF system FeS cluster assembly; PFAM: ABC transporter-like; KEGG: ttm:Tthe_2639 FeS assembly ATPase SufC; SMART: ATPase, AAA+ type, core. (250 aa)
AEF18340.1SMART: ATPase, AAA+ type, core; KEGG: ttm:Tthe_2690 AAA ATPase. (326 aa)
AEF18364.1Xenobiotic-transporting ATPase; PFAM: ABC transporter-like; KEGG: smf:Smon_0068 ABC transporter related protein; SMART: ATPase, AAA+ type, core. (365 aa)
AEF18366.1SMART: ATPase, AAA+ type, core; KEGG: ttm:Tthe_0316 AAA ATPase. (267 aa)
AEF18380.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (442 aa)
Your Current Organism:
Thermoanaerobacterium xylanolyticum
NCBI taxonomy Id: 858215
Other names: T. xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum DSM 7097, Thermoanaerobacterium xylanolyticum LX-11, Thermoanaerobacterium xylanolyticum str. LX-11, Thermoanaerobacterium xylanolyticum strain LX-11
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