(31 nodes) Preribosome, large subunit precursor, and Ribosome biogenesis network (Exophiala dermatitidis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	YTM1	Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (459 aa)
	H6BKM1_EXODN	Uncharacterized protein. (390 aa)
	H6BMJ1_EXODN	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (574 aa)
	H6BNC5_EXODN	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (231 aa)
	H6BNL8_EXODN	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (248 aa)
	NOP7	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (674 aa)
	SPB1	AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (835 aa)
	H6BPB1_EXODN	Uncharacterized protein. (389 aa)
	H6BPU3_EXODN	Ribosomal RNA small subunit methyltransferase F; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (717 aa)
	ERB1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (810 aa)
	H6BR48_EXODN	Valyl-tRNA synthetase. (388 aa)
	H6BR72_EXODN	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family. (130 aa)
	H6BUA3_EXODN	Uncharacterized protein. (361 aa)
	H6BUA4_EXODN	Brix domain-containing protein. (336 aa)
	H6BUS3_EXODN	50S ribosomal protein L24e. (198 aa)
	H6BV54_EXODN	RRM domain-containing protein. (763 aa)
	H6BXA4_EXODN	Uncharacterized protein. (274 aa)
	H6BY27_EXODN	Protein MAK16; Belongs to the MAK16 family. (321 aa)
	H6BYL2_EXODN	Uncharacterized protein. (443 aa)
	H6BZ51_EXODN	Brix-domain ribosomal biogenesis protein. (446 aa)
	H6C0A3_EXODN	Uncharacterized protein. (711 aa)
	H6C209_EXODN	Uncharacterized protein. (231 aa)
	H6C221_EXODN	Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (688 aa)
	H6C222_EXODN	60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (189 aa)
	H6C255_EXODN	C2H2-type domain-containing protein. (111 aa)
	H6C4I2_EXODN	RNA helicase. (631 aa)
	H6C540_EXODN	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (659 aa)
	H6C6G0_EXODN	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (429 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (249 aa)
	H6C8J2_EXODN	CP-type G domain-containing protein. (552 aa)
	H6CBK5_EXODN	Ribosome biogenesis protein n. (261 aa)

Your Current Organism:

Exophiala dermatitidis

NCBI taxonomy Id: 858893
Other names: E. dermatitidis NIH/UT8656, Exophiala dermatitidis NIH 8656, Exophiala dermatitidis NIH/UT8656, Wangiella dermatitidis NIH 8656

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERB1	H6BKM1_EXODN	H6BR01	H6BKM1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.997
ERB1	H6BMJ1_EXODN	H6BR01	H6BMJ1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.991
ERB1	H6BNC5_EXODN	H6BR01	H6BNC5	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.869
ERB1	H6BNL8_EXODN	H6BR01	H6BNL8	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.997
ERB1	H6BPB1_EXODN	H6BR01	H6BPB1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.994
ERB1	H6BPU3_EXODN	H6BR01	H6BPU3	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosomal RNA small subunit methyltransferase F; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.997
ERB1	H6BR48_EXODN	H6BR01	H6BR48	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Valyl-tRNA synthetase.	0.992
ERB1	H6BUA3_EXODN	H6BR01	H6BUA3	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.980
ERB1	H6BUA4_EXODN	H6BR01	H6BUA4	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Brix domain-containing protein.	0.987
ERB1	H6BUS3_EXODN	H6BR01	H6BUS3	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	50S ribosomal protein L24e.	0.994
ERB1	H6BV54_EXODN	H6BR01	H6BV54	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	RRM domain-containing protein.	0.987
ERB1	H6BXA4_EXODN	H6BR01	H6BXA4	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.994
ERB1	H6BY27_EXODN	H6BR01	H6BY27	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Protein MAK16; Belongs to the MAK16 family.	0.969
ERB1	H6BYL2_EXODN	H6BR01	H6BYL2	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.967
ERB1	H6BZ51_EXODN	H6BR01	H6BZ51	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Brix-domain ribosomal biogenesis protein.	0.982
ERB1	H6C0A3_EXODN	H6BR01	H6C0A3	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.996
ERB1	H6C209_EXODN	H6BR01	H6C209	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.982
ERB1	H6C221_EXODN	H6BR01	H6C221	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family.	0.993
ERB1	H6C222_EXODN	H6BR01	H6C222	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.992
ERB1	H6C255_EXODN	H6BR01	H6C255	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	C2H2-type domain-containing protein.	0.694

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