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H6CAW5_EXODN H6CAW5_EXODN H6BK99_EXODN H6BK99_EXODN H6BKG9_EXODN H6BKG9_EXODN NBP35 NBP35 H6BKV0_EXODN H6BKV0_EXODN H6BLE2_EXODN H6BLE2_EXODN H6BLL0_EXODN H6BLL0_EXODN H6BLX6_EXODN H6BLX6_EXODN H6BN29_EXODN H6BN29_EXODN H6BN40_EXODN H6BN40_EXODN H6BPG7_EXODN H6BPG7_EXODN NTH1 NTH1 H6BPM4_EXODN H6BPM4_EXODN H6BPX4_EXODN H6BPX4_EXODN H6BT86_EXODN H6BT86_EXODN DRE2 DRE2 H6BU44_EXODN H6BU44_EXODN H6BU88_EXODN H6BU88_EXODN H6BVF4_EXODN H6BVF4_EXODN CFD1 CFD1 H6BW13_EXODN H6BW13_EXODN H6BW14_EXODN H6BW14_EXODN H6BWS1_EXODN H6BWS1_EXODN H6BX03_EXODN H6BX03_EXODN H6BYB5_EXODN H6BYB5_EXODN H6C256_EXODN H6C256_EXODN H6C3X3_EXODN H6C3X3_EXODN H6C4N3_EXODN H6C4N3_EXODN H6C4R9_EXODN H6C4R9_EXODN H6C5N1_EXODN H6C5N1_EXODN H6C617_EXODN H6C617_EXODN H6C6W7_EXODN H6C6W7_EXODN H6C6Z3_EXODN H6C6Z3_EXODN H6C7M5_EXODN H6C7M5_EXODN H6C8G7_EXODN H6C8G7_EXODN H6C8U8_EXODN H6C8U8_EXODN H6CAC1_EXODN H6CAC1_EXODN H6CB15_EXODN H6CB15_EXODN H6CBC7_EXODN H6CBC7_EXODN H6CBU4_EXODN H6CBU4_EXODN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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H6CAW5_EXODNDNA polymerase. (1773 aa)
H6BK99_EXODNElongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (574 aa)
H6BKG9_EXODNFlavodoxin-like domain-containing protein. (804 aa)
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa)
H6BKV0_EXODNSulfite reductase (Ferredoxin). (1551 aa)
H6BLE2_EXODNDNA polymerase. (1107 aa)
H6BLL0_EXODNSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (297 aa)
H6BLX6_EXODN2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2; Belongs to the DPH1/DPH2 family. DPH2 subfamily. (562 aa)
H6BN29_EXODNBiotin synthetase. (409 aa)
H6BN40_EXODNUncharacterized protein. (1007 aa)
H6BPG7_EXODNDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2236 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (468 aa)
H6BPM4_EXODNUncharacterized protein. (556 aa)
H6BPX4_EXODNNADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial; Belongs to the complex I 49 kDa subunit family. (480 aa)
H6BT86_EXODNElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (642 aa)
DRE2Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...] (331 aa)
H6BU44_EXODNAconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (808 aa)
H6BU88_EXODNNADH-ubiquinone oxidoreductase 19.3 kDa subunit, mitochondrial; Belongs to the complex I 20 kDa subunit family. (230 aa)
H6BVF4_EXODNFerredoxin hydrogenase; Belongs to the NARF family. (641 aa)
CFD1Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (324 aa)
H6BW13_EXODNDNA replication ATP-dependent helicase Dna2. (1190 aa)
H6BW14_EXODNDNA replication ATP-dependent helicase Dna2. (512 aa)
H6BWS1_EXODNNADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial, variant; Belongs to the complex I 75 kDa subunit family. (739 aa)
H6BX03_EXODNTranslation initiation factor RLI1. (603 aa)
H6BYB5_EXODNHomoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (804 aa)
H6C256_EXODNAconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (734 aa)
H6C3X3_EXODNNADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial. (228 aa)
H6C4N3_EXODNLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (419 aa)
H6C4R9_EXODNNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (504 aa)
H6C5N1_EXODN3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (778 aa)
H6C617_EXODNFe-S_biosyn domain-containing protein. (251 aa)
H6C6W7_EXODNZn(2)-C6 fungal-type domain-containing protein. (767 aa)
H6C6Z3_EXODNThioredoxin-like protein. (315 aa)
H6C7M5_EXODNDNA repair helicase rad15. (819 aa)
H6C8G7_EXODNMolybdenum cofactor biosynthesis protein A. (947 aa)
H6C8U8_EXODNDNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (503 aa)
H6CAC1_EXODNATP-binding protein. (335 aa)
H6CB15_EXODNUncharacterized protein. (294 aa)
H6CBC7_EXODN2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (445 aa)
H6CBU4_EXODNAconitase. (824 aa)
Your Current Organism:
Exophiala dermatitidis
NCBI taxonomy Id: 858893
Other names: E. dermatitidis NIH/UT8656, Exophiala dermatitidis NIH 8656, Exophiala dermatitidis NIH/UT8656, Wangiella dermatitidis NIH 8656
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