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H6C0K1_EXODN H6C0K1_EXODN H6BTE6_EXODN H6BTE6_EXODN URM1 URM1 H6C8G7_EXODN H6C8G7_EXODN H6C890_EXODN H6C890_EXODN H6C3L1_EXODN H6C3L1_EXODN NCS6 NCS6 H6C2H0_EXODN H6C2H0_EXODN NCS2 NCS2 H6BLB1_EXODN H6BLB1_EXODN H6BMG5_EXODN H6BMG5_EXODN H6BML0_EXODN H6BML0_EXODN H6BPK8_EXODN H6BPK8_EXODN cnxH cnxH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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H6C0K1_EXODNUncharacterized protein. (155 aa)
H6BTE6_EXODNThiF domain-containing protein. (514 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (105 aa)
H6C8G7_EXODNMolybdenum cofactor biosynthesis protein A. (947 aa)
H6C890_EXODNRhodanese domain-containing protein. (207 aa)
H6C3L1_EXODNThiosulfate sulfurtransferase. (293 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (421 aa)
H6C2H0_EXODNIron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (206 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (365 aa)
H6BLB1_EXODNMolybdopterin biosynthesis protein MoeB. (477 aa)
H6BMG5_EXODNThiosulfate sulfurtransferase. (314 aa)
H6BML0_EXODNPeroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (166 aa)
H6BPK8_EXODNCysteine desulfurase. (515 aa)
cnxHMolybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. (197 aa)
Your Current Organism:
Exophiala dermatitidis
NCBI taxonomy Id: 858893
Other names: E. dermatitidis NIH/UT8656, Exophiala dermatitidis NIH 8656, Exophiala dermatitidis NIH/UT8656, Wangiella dermatitidis NIH 8656
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