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hemB hemB hemC hemC hemA hemA hemL hemL hemH hemH hemE hemE hemN hemN HP_1224 HP_1224 HP_1226 HP_1226 HP_1484 HP_1484
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second shell of interactors
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hemBDelta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). (323 aa)
hemCPorphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (306 aa)
hemAglutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (449 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase (hemL); Similar to GB:D26562 SP:P23893 GB:X53696 PID:41621 PID:473813 percent identity: 51.30; identified by sequence similarity; putative. (430 aa)
hemHFerrochelatase (hemH); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (334 aa)
hemEUroporphyrinogen decarboxylase (hemE); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (340 aa)
hemNOxygen-independent coproporphyrinogen III oxidase (hemN); Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
HP_1224Uroporphyrinogen III cosynthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (226 aa)
HP_1226Oxygen-independent coproporphyrinogen III oxidase (hemN); Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (352 aa)
HP_1484Conserved hypothetical integral membrane protein; Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX. Is involved in the biosynthesis of tetrapyrrole molecules like heme. Does not use oxygen or artificial electron acceptors such as menadione or benzoquinone. Belongs to the HemJ family. (148 aa)
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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