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| | ribH | Riboflavin synthase beta chain (ribE); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (227 aa) |
| | panC | Pantoate-beta-alanine ligase (panC); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (276 aa) |
| | gltA | Citrate synthase (gltA); Similar to SP:P09948 GB:U14334 GB:U20244 PID:152472 PID:540095 percent identity: 47.78; identified by sequence similarity; putative. (426 aa) |
| | icd | Isocitrate dehydrogenase (icd); Similar to GB:J02799 SP:P08200 PID:146432 GB:U00096 PID:1651560 percent identity: 70.73; identified by sequence similarity; putative; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (425 aa) |
| | panD | Aspartate 1-decarboxylase (panD); Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (117 aa) |
| | HP_0043 | Mannose-6-phosphate isomerase (pmi) or (algA); Similar to PIR:A25638 percent identity: 42.83; identified by sequence similarity; putative; Belongs to the mannose-6-phosphate isomerase type 2 family. (470 aa) |
| | gmd | GDP-D-mannose dehydratase (rfbD); Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (381 aa) |
| | fcl | Nodulation protein (nolK); Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (310 aa) |
| | HP_0055 | Proline permease (putP); Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (496 aa) |
| | HP_0056 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1185 aa) |
| | glmM | Urease protein (ureC); Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (445 aa) |
| | HP_0090 | Malonyl coenzyme A-acyl carrier protein transacylase (fabD); Similar to GB:L42023 SP:P43712 PID:1003213 PID:1222070 PID:1204413 percent identity: 35.39; identified by sequence similarity; putative. (309 aa) |
| | HP_0096 | Phosphoglycerate dehydrogenase; Similar to GB:L77117 PID:1591676 percent identity: 31.03; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa) |
| | thrC | Threonine synthase (thrC); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (486 aa) |
| | HP_0102 | Conserved hypothetical protein; Similar to PID:1197639 PID:1197649 percent identity: 29.26; identified by sequence similarity; putative. (259 aa) |
| | HP_0104 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase (cpdB); Similar to GB:L42023 SP:P44764 PID:1004048 PID:1220657 PID:1204834 percent identity: 31.83; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family. (581 aa) |
| | luxS | Conserved hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity); Belongs to the LuxS family. (155 aa) |
| | metB | Cystathionine gamma-synthase (metB); Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (380 aa) |
| | cysM | Cysteine synthetase (cysK); Similar to GB:D26185 SP:P37887 PID:467462 GB:AL009126 percent identity: 45.72; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | ppsA | Phosphoenolpyruvate synthase (ppsA); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa) |
| | sdaA | L-serine deaminase (sdaA); Similar to GB:M28695 SP:P16095 PID:290464 GB:U00096 PID:1736451 percent identity: 45.81; identified by sequence similarity; putative. (455 aa) |
| | HP_0133 | Serine transporter (sdaC); Similar to SP:P36559 GB:U01233 PID:402256 PID:882691 GB:U00096 percent identity: 44.64; identified by sequence similarity; putative. (413 aa) |
| | HP_0134 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (dhs1); Similar to GB:M74819 SP:P29976 PID:166688 percent identity: 54.61; identified by sequence similarity; putative. (449 aa) |
| | bcp | Bacterioferritin comigratory protein (bcp); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. BCP/PrxQ subfamily. (152 aa) |
| | HP_0137 | Predicted coding region HP0137; Hypothetical protein; identified by GeneMark; putative. (211 aa) |
| | HP_0138 | Conserved hypothetical iron-sulfur protein; Similar to GP:1657506 percent identity: 41.19; identified by sequence similarity; putative. (481 aa) |
| | HP_0139 | Conserved hypothetical secreted protein; Similar to GP:1657505 percent identity: 37.08; identified by sequence similarity; putative. (242 aa) |
| | HP_0140 | L-lactate permease (lctP); Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (549 aa) |
| | HP_0141 | L-lactate permease (lctP); Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (551 aa) |
| | eno | Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | aroK | Shikimic acid kinase I (aroK); Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (162 aa) |
| | fba | Fructose-bisphosphate aldolase (tsr); Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (307 aa) |
| | glyA | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa) |
| | frdB | Fumarate reductase, iron-sulfur subunit (frdB); Similar to SP:P17596 PID:48514 PID:2282000 percent identity: 70.76; identified by sequence similarity; putative. (245 aa) |
| | frdA | Fumarate reductase, flavoprotein subunit (frdA); Similar to SP:P17412 PID:48513 PID:2281999 percent identity: 69.41; identified by sequence similarity; putative. (714 aa) |
| | frdC | Fumarate reductase, cytochrome b subunit (frdC); Di-heme cytochrome of the fumarate reductase complex. (255 aa) |
| | tpiA | Triosephosphate isomerase (tpi); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (234 aa) |
| | fabI | Enoyl-(acyl-carrier-protein) reductase (NADH) (fabI); Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. (275 aa) |
| | fabH | Beta-ketoacyl-acyl carrier protein synthase III (fabH); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (331 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase (dapE); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (383 aa) |
| | dxr | Conserved hypothetical protein; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (368 aa) |
| | HP_0240 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. (307 aa) |
| | purA | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (411 aa) |
| | pyrC | Dihydroorotase (pyrC); Non-functional DHOase. (378 aa) |
| | HP_0276 | Predicted coding region HP0276; Hypothetical protein; identified by GeneMark; putative. (185 aa) |
| | aroB | 3-dehydroquinate synthase (aroB); Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (343 aa) |
| | lysA | Diaminopimelate decarboxylase (dap decarboxylase) (lysA); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (405 aa) |
| | HP_0291 | Predicted coding region HP0291; Hypothetical protein; identified by GeneMark; putative. (96 aa) |
| | HP_0293 | Para-aminobenzoate synthetase (pabB); Similar to GB:K02673 SP:P05041 GB:U07748 GB:U07749 GB:U07755 percent identity: 35.09; identified by sequence similarity; putative. (559 aa) |
| | gmk | 5'-guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase, putative (dxs); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (618 aa) |
| | HP_0360 | UDP-glucose 4-epimerase; Similar to GB:Z25478 PID:396521 SP:Q59083 percent identity: 43.08; identified by sequence similarity; putative; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (344 aa) |
| | nrdB | Ribonucleoside diphosphate reductase, beta subunit (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (341 aa) |
| | HP_0370 | Biotin carboxylase (accC); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (458 aa) |
| | HP_0371 | Biotin carboxyl carrier protein (fabE); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | dcd | Deoxycytidine triphosphate deaminase (dcd); Catalyzes the deamination of dCTP to dUTP. (190 aa) |
| | gdhA | Glutamate dehydrogenase (gdhA); Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. (448 aa) |
| | HP_0397 | Phosphoglycerate dehydrogenase (serA); Similar to GB:U00096 PID:1789279 PID:2294548 percent identity: 32.47; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (524 aa) |
| | ispH | Penicillin tolerance protein (lytB); Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (274 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase (aroA); Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa) |
| | guaA | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. (508 aa) |
| | HP_0509 | Glycolate oxidase subunit (glcD); Similar to GP:1763300 percent identity: 98.01; identified by sequence similarity; putative. (459 aa) |
| | dapB | Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (254 aa) |
| | glnA | Glutamine synthetase (glnA); Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (481 aa) |
| | accA | Acetyl-coenzyme A carboxylase (accA); Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (312 aa) |
| | HP_0558 | Beta ketoacyl-acyl carrier protein synthase II (fabF); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | acpP | Acyl carrier protein (acpP); Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (78 aa) |
| | HP_0561 | 3-ketoacyl-acyl carrier protein reductase (fabG); Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | dapF | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (273 aa) |
| | apt | Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa) |
| | HP_0574 | Galactosidase acetyltransferase (lacA); Similar to GB:L43967 PID:1046109 SP:P47636 percent identity: 41.01; identified by sequence similarity; putative. (151 aa) |
| | folD | Methylene-tetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa) |
| | HP_0588 | Ferrodoxin-like protein; Similar to SP:P18083 GB:D00590 PID:217132 percent identity: 42.59; identified by sequence similarity; putative. (113 aa) |
| | HP_0589 | Ferredoxin oxidoreductase, alpha subunit; Similar to GB:L77117 PID:1592279 percent identity: 42.74; identified by sequence similarity; putative. (375 aa) |
| | HP_0590 | Ferredoxin oxidoreductase, beta subunit; Similar to GB:L77117 PID:1591241 percent identity: 43.23; identified by sequence similarity; putative. (273 aa) |
| | HP_0591 | Ferredoxin oxidoreductase, gamma subunit; Similar to GB:L77117 PID:1591240 percent identity: 32.80; identified by sequence similarity; putative. (186 aa) |
| | adk | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (191 aa) |
| | HP_0624 | Solute-binding signature and mitochondrial signature protein (aspB); Similar to PID:1146246 SP:P53001 GB:AL009126 percent identity: 26.39; identified by sequence similarity; putative. (375 aa) |
| | ispG | Protein E (gcpE); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (359 aa) |
| | dapD | Tetrahydrodipicolinate N-succinyltransferase (dapD); Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (401 aa) |
| | HP_0646 | UDP-glucose pyrophosphorylase (galU); Similar to GP:1345068 percent identity: 65.56; identified by sequence similarity; putative. (273 aa) |
| | aspA | Aspartate ammonia-lyase (aspA); Similar to GB:U14003 SP:P04422 GB:L20944 GB:X02307 GB:X04066 percent identity: 55.53; identified by sequence similarity; putative; Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. (468 aa) |
| | HP_0652 | Phosphoserine phosphatase (serB); Similar to SP:P06862 GB:X03046 PID:42948 PID:537228 GB:U00096 percent identity: 36.55; identified by sequence similarity; putative. (207 aa) |
| | ftnA | Nonheme iron-containing ferritin (pfr); Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. (167 aa) |
| | aroC | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | HP_0666 | Anaerobic glycerol-3-phosphate dehydrogenase, subunit C (glpC); Similar to GB:M20938 SP:P13034 PID:146179 GB:U00096 PID:1788576 percent identity: 26.52; identified by sequence similarity; putative. (433 aa) |
| | HP_0672 | Solute-binding signature and mitochondrial signature protein (aspB); Similar to PID:1146246 SP:P53001 GB:AL009126 percent identity: 47.42; identified by sequence similarity; putative. (390 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase 1 alpha subunit (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (788 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase (glmU); Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (433 aa) |
| | ansA | L-asparaginase II (ansB); Similar to PID:758652 PID:895919 SP:P50286 percent identity: 54.13; identified by sequence similarity; putative; Belongs to the asparaginase 1 family. (330 aa) |
| | dcuA | Anaerobic C4-dicarboxylate transport protein (dcuA); Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. (443 aa) |
| | HP_0735 | Xanthine guanine phosphoribosyl transferase (gpt); Similar to GB:L42023 SP:P43859 PID:1005561 PID:1005597 PID:1220758 percent identity: 27.12; identified by sequence similarity; putative. (153 aa) |
| | HP_0736 | Phosphoserine aminotransferase (serC); Similar to GB:L77117 PID:1591623 percent identity: 30.73; identified by sequence similarity; putative. (369 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase (prsA); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa) |
| | acnB | Aconitase B (acnB); Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. (853 aa) |
| | ribA | GTP cyclohydrolase II (ribA); Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (192 aa) |
| | ribB | GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase (ribA, ribB); Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. (344 aa) |
| | hom | Homoserine dehydrogenase (metL); Similar to SP:P19582 GB:M23217 PID:558494 PID:809663 GB:AL009126 percent identity: 37.97; identified by sequence similarity; putative; Belongs to the homoserine dehydrogenase family. (421 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (481 aa) |
| | coaE | Conserved hypothetical ATP binding protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (196 aa) |
| | HP_0841 | Pantothenate metabolism flavoprotein (dfp); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (425 aa) |
| | guaC | GMP reductase (guaC); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa) |
| | coaX | Predicted coding region HP0862; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Can also utilize CTP or GTP instead of ATP as a phosphoryl donor, albeit to a lesser extent. (223 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (145 aa) |
| | cysS | cysteinyl-tRNA synthetase (cysS); Similar to GB:U05676 SP:P41259 PID:471728 percent identity: 97.34; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa) |
| | HP_0905 | Phosphotransacetylase (pta); Similar to SP:P39184 GB:U00096 PID:1359438 PID:1788635 PID:1799670 percent identity: 29.46; identified by sequence similarity; putative. (223 aa) |
| | carB | Carbamoyl-phosphate synthase (glutamine-hydrolysing) (pyrAb); Similar to GB:X73308 SP:P46537 PID:312443 percent identity: 48.63; identified by sequence similarity; putative. (1085 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase (gap); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (332 aa) |
| | folE | GTP cyclohydrolase I (folE); Similar to PID:757796 SP:P51594 percent identity: 50.87; identified by sequence similarity; putative. (180 aa) |
| | HP_0929 | Geranyltranstransferase (ispA); Similar to GB:L42023 SP:P45204 PID:1007535 PID:1221581 PID:1205674 percent identity: 39.85; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. (303 aa) |
| | surE | Stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (267 aa) |
| | HP_0936 | Proline/betaine transporter (proP); Similar to SP:P30848 GB:U14003 GB:M83089 PID:147357 PID:536955 percent identity: 29.15; identified by sequence similarity; putative. (389 aa) |
| | accD | acetyl-CoA carboxylase beta subunit (accD); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | gpmI | Phosphoglycerate mutase (pgm); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (491 aa) |
| | pyrD | Dihydroorotate dehydrogenase (pyrD); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (351 aa) |
| | dapA | Dihydrodipicolinate synthetase (dapA); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa) |
| | ispDF | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (406 aa) |
| | folK | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (folK); Similar to GB:D26185 SP:P29252 PID:467468 GB:AL009126 percent identity: 34.56; identified by sequence similarity; putative; Belongs to the HPPK family. (163 aa) |
| | aroQ | 3-dehydroquinase type II (aroQ); Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (167 aa) |
| | acsA | acetyl-CoA synthetase (acoE); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (662 aa) |
| | thrB | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (270 aa) |
| | pyrB | Aspartate transcarbamoylase (pyrB); Similar to GB:M13128 SP:P05654 PID:143384 PID:143387 GB:AL009126 percent identity: 38.70; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa) |
| | HP_1088 | Transketolase A (tktA); Similar to GB:L42023 SP:P43757 PID:1006246 PID:1221138 PID:1205272 percent identity: 46.74; identified by sequence similarity; putative; Belongs to the transketolase family. (641 aa) |
| | HP_1097 | Predicted coding region HP1097; Hypothetical protein; identified by GeneMark; putative. (31 aa) |
| | hcpC | Conserved hypothetical secreted protein; May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives; Belongs to the hcp beta-lactamase family. (290 aa) |
| | HP_1099 | 2-keto-3-deoxy-6-phosphogluconate aldolase (eda); Similar to GB:L20897 GB:M87458 GB:X63694 GB:X68871 PID:145827 percent identity: 50.25; identified by sequence similarity; putative. (208 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa) |
| | zwf | Glucose-6-phosphate dehydrogenase (g6pD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (425 aa) |
| | pgl | Glucose-6-phosphate 1-dehydrogenase (devB); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (227 aa) |
| | glk | Glucokinase (glk); Similar to SP:P46880 PID:736416 GB:U00096 PID:1788732 PID:1799799 percent identity: 42.14; identified by sequence similarity; putative; Belongs to the bacterial glucokinase family. (336 aa) |
| | HP_1104 | Cinnamyl-alcohol dehydrogenase ELI3-2 (cad); Similar to GB:X67815 SP:Q02972 PID:16269 percent identity: 43.97; identified by sequence similarity; putative. (348 aa) |
| | HP_1108 | Pyruvate ferredoxin oxidoreductase, gamma subunit; Similar to PID:1197358 percent identity: 37.16; identified by sequence similarity; putative. (186 aa) |
| | HP_1109 | Pyruvate ferredoxin oxidoreductase, delta subunit; Similar to GP:1197392 percent identity: 46.97; identified by sequence similarity; putative. (130 aa) |
| | HP_1110 | Pyruvate ferredoxin oxidoreductase, alpha subunit; Similar to PID:1197363 percent identity: 41.03; identified by sequence similarity; putative. (407 aa) |
| | HP_1111 | Pyruvate ferredoxin oxidoreductase, beta subunit; Similar to PID:1197393 GB:AE000512 percent identity: 43.67; identified by sequence similarity; putative. (314 aa) |
| | purB | Adenylosuccinate lyase (purB); Similar to GB:J02732 SP:P12047 PID:143366 GB:AL009126 percent identity: 49.53; identified by sequence similarity; putative. (440 aa) |
| | HP_1118 | Gamma-glutamyltranspeptidase (ggt); Similar to GB:M28722 SP:P18956 PID:146133 PID:466583 PID:606382 percent identity: 53.21; identified by sequence similarity; putative. (567 aa) |
| | fmt | methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (303 aa) |
| | pgi | Glucose-6-phosphate isomerase (pgi); Similar to SP:P11537 GB:X15196 PID:396360 PID:42377 GB:U00096 percent identity: 53.32; identified by sequence similarity; putative. (545 aa) |
| | cstA | Carbon starvation protein (cstA); Involved in peptide utilization. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. (687 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa) |
| | HP_1207 | Predicted coding region HP1207; Hypothetical protein; identified by GeneMark; putative. (222 aa) |
| | cysE | Serine acetyltransferase (cysE); Similar to GP:1518452 percent identity: 98.25; identified by sequence similarity; putative. (171 aa) |
| | purD | Glycinamide ribonucleotide synthetase (purD); Similar to GB:L42023 SP:P43845 PID:1005977 PID:1220991 PID:1205135 percent identity: 31.82; identified by sequence similarity; putative; Belongs to the GARS family. (424 aa) |
| | uppS | Conserved hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (234 aa) |
| | HP_1222 | D-lactate dehydrogenase (dld); Similar to GB:L42023 PID:1006517 PID:1221287 PID:1205408 SP:Q57252 percent identity: 26.99; identified by sequence similarity; putative. (948 aa) |
| | lysC | Aspartokinase (lysC); Similar to GB:M93419 PID:142540 percent identity: 48.01; identified by sequence similarity; putative; Belongs to the aspartokinase family. (405 aa) |
| | folP | Dihydropteroate synthase (folP); Bifunctional enzyme that catalyzes the formation of dihydropteroate, the immediate precursor of folic acid and the reduction of dihydropteroate to tetrahydropteroate. In the C-terminal section; belongs to the DHPS family. (380 aa) |
| | carA | Carbamoyl-phosphate synthetase (pyrAa); Similar to GB:M36540 SP:P14845 GB:X13200 PID:552013 PID:581754 percent identity: 39.68; identified by sequence similarity; putative; Belongs to the CarA family. (375 aa) |
| | amiF | Aliphatic amidase (aimE); Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide. Probably involved in the nitrogen metabolism of H.pylori; Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family. (334 aa) |
| | aroE | Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (263 aa) |
| | pyrE | Orotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (201 aa) |
| | HP_1275 | Phosphomannomutase (algC){Pseudomonas aeruginosa}; Similar to GB:M60873 SP:P26276 GB:S43866 PID:150994 percent identity: 39.00; identified by sequence similarity; putative. (459 aa) |
| | trpA | Tryptophan synthase, alpha subunit (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | trpB | Tryptophan synthase, beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpC | Anthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). (452 aa) |
| | trpG | Anthranilate synthase component II (trpD); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (194 aa) |
| | trpE | Anthranilate synthase component I (trpE); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (500 aa) |
| | fumC | Fumarase (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | pgk | Phosphoglycerate kinase; Similar to GB:U37701 SP:P50318 PID:1022805 percent identity: 47.31; identified by sequence similarity; putative. (402 aa) |
| | HP_1346 | Glyceraldehyde-3-phosphate dehydrogenase (gap); Similar to GB:M24493 SP:P00362 PID:142952 percent identity: 46.69; identified by sequence similarity; putative; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa) |
| | HP_1380 | Prephenate dehydrogenase (tyrA); Similar to SP:P20692 PID:143815 GB:AL009126 percent identity: 31.02; identified by sequence similarity; putative. (265 aa) |
| | fbp | Fructose-1,6-bisphosphatase; Similar to SP:Q05079 percent identity: 36.44; identified by sequence similarity; putative. (290 aa) |
| | rpe | D-ribulose-5-phosphate 3 epimerase (rpe); Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa) |
| | purU | Formyltetrahydrofolate hydrolase (purU); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa) |
| | ispE | Conserved hypothetical protein; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (268 aa) |
| | tmk | Thymidylate kinase (tmk); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. (191 aa) |
| | coaD | Lipopolysaccharide core biosynthesis protein (kdtB); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (157 aa) |
| | tal | Transaldolase (tal); Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (316 aa) |
| | HP_1505 | Riboflavin biosynthesis protein (ribG); Similar to GB:L42023 SP:P44326 PID:1006089 PID:1221052 PID:1205192 percent identity: 33.10; identified by sequence similarity; putative. (344 aa) |
| | HP_1510 | Conserved hypothetical protein; Similar to PID:406425 percent identity: 30.65; identified by sequence similarity; putative. (117 aa) |
| | glmS | Glucosamine fructose-6-phosphate aminotransferase (isomerizing) (glmS); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (597 aa) |
| | thyX | Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant. Belongs to the thymidylate synthase ThyX family. (231 aa) |
| | HP_1545 | Folylpolyglutamate synthase (folC); Similar to GB:L42023 SP:P43775 PID:1007194 PID:1221390 PID:1205502 percent identity: 35.17; identified by sequence similarity; putative. (394 aa) |
| | HP_1574 | Riboflavin synthase alpha subunit (ribC); Similar to PID:1173517 SP:P50854 percent identity: 32.80; identified by sequence similarity; putative. (206 aa) |
