(44 nodes) Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides network (Bacillus subtilis natto)

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Your Input:
	yaaE	Glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa)
	cwlD	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
	ybbE	Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
	ybgJ	Sodium:alanine symporter; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. (327 aa)
	yccC	L-asparaginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the asparaginase 1 family. (375 aa)
	nadE	Hypothetical protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (272 aa)
	purQ	Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (227 aa)
	purL	Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (742 aa)
	yhdZ	NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (247 aa)
	xlyB	Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
	xlyA	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
	purU	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (300 aa)
	ykrU	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
	ykuR	N-acetyldiaminopimelate deacetylase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (374 aa)
	def	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (184 aa)
	ylaM	Catalyzes the formation of glutamate from glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. (309 aa)
	def-2	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (160 aa)
	cheB	Chemotaxis response regulator protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (357 aa)
	cheD	CheY-P-specific phosphatase CheC; Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the cheA kinase. (166 aa)
	cwlC	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
	AMK72415.1	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
	AMK72602.1	Bacillithiol biosynthesis deacetylase BshB2; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
	yojF	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
	ypjG	Bacillithiol biosynthesis deacetylase BshB1; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
	ansA	L-asparaginase 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
	yqjN	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
	yqiI	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
	cwlH	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
	yrvJ	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (518 aa)
	acuC	Histone deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
	yubE	Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
	xlyA-2	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
	AMK73789.1	Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
	AMK73920.1	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
	AMK73927.1	Phage tail protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
	hisH	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa)
	nagA	N-acetylglucosamine-6-phosphate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
	lytC	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
	lytD	beta-N-acetylglucosaminidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (880 aa)
	ureC	Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology. (569 aa)
	ureB	Urease subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease beta subunit family. (124 aa)
	ureA	Urease subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease gamma subunit family. (105 aa)
	pyrG	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa)
	rocB	Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)

Your Current Organism:

Bacillus subtilis natto

NCBI taxonomy Id: 86029
Other names: B. subtilis subsp. natto, Bacillus subtilis subsp. natto, Bacillus subtilis var. natto

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMK72602.1	yojF	AWV81_10945	AWV81_10950	Bacillithiol biosynthesis deacetylase BshB2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.980
AMK72602.1	ypjG	AWV81_10945	AWV81_11580	Bacillithiol biosynthesis deacetylase BshB2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Bacillithiol biosynthesis deacetylase BshB1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.870
AMK73920.1	AMK73927.1	AWV81_18185	AWV81_18220	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phage tail protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.421
AMK73920.1	xlyA	AWV81_18185	AWV81_07200	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.421
AMK73927.1	AMK73920.1	AWV81_18220	AWV81_18185	Phage tail protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.421
AMK73927.1	cwlD	AWV81_18220	AWV81_00925	Phage tail protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.533
acuC	yhdZ	AWV81_15150	AWV81_05420	Histone deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.	0.931
ansA	yccC	AWV81_12235	AWV81_01580	L-asparaginase 1; Derived by automated computational analysis using gene prediction method: Protein Homology.	L-asparaginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the asparaginase 1 family.	0.923
cheB	cheD	AWV81_09100	AWV81_09120	Chemotaxis response regulator protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	CheY-P-specific phosphatase CheC; Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the cheA kinase.	0.981
cheD	cheB	AWV81_09120	AWV81_09100	CheY-P-specific phosphatase CheC; Deamidates glutamine residues to glutamate on methyl- accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the cheA kinase.	Chemotaxis response regulator protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	0.981
cwlC	cwlD	AWV81_09610	AWV81_00925	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
cwlC	cwlH	AWV81_09610	AWV81_13365	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.785
cwlC	lytC	AWV81_09610	AWV81_19000	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.580
cwlC	yqiI	AWV81_09610	AWV81_12465	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
cwlC	yrvJ	AWV81_09610	AWV81_14040	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.593
cwlD	AMK73927.1	AWV81_00925	AWV81_18220	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phage tail protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.533
cwlD	cwlC	AWV81_00925	AWV81_09610	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
cwlH	cwlC	AWV81_13365	AWV81_09610	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.785
lytC	cwlC	AWV81_19000	AWV81_09610	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.580
lytC	lytD	AWV81_19000	AWV81_19095	N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	beta-N-acetylglucosaminidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.468