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AMK73705.1 AMK73705.1 fadN fadN yqjI yqjI bcd bcd bkdR bkdR AMK72885.1 AMK72885.1 folD folD proI proI yqjQ yqjQ mleA mleA serA serA gudB gudB gpsA gpsA tyrA tyrA dapB dapB kduD kduD AMK72641.1 AMK72641.1 fabG-2 fabG-2 yogA yogA yneT yneT tdh tdh fabG fabG asd asd spoVFA spoVFA dxr dxr sucD sucD fabG-4 fabG-4 ylnF ylnF ylbQ ylbQ ykqB ykqB ykpB ykpB yvrD yvrD yvaA yvaA yvaG yvaG gapA gapA yveM yveM yvcT yvcT tuaD tuaD ywqF ywqF ywnB ywnB ywkA ywkA ywfH ywfH ywfD ywfD rocG rocG zwf zwf comER comER yueD yueD AMK73533.1 AMK73533.1 yuxG yuxG yulF yulF yuaA yuaA ytcB ytcB AMK73418.1 AMK73418.1 melA melA aroD aroD yqeC yqeC adhB adhB adhA adhA yrbE yrbE hemA hemA ilvC ilvC gapB gapB mdh mdh ytsJ ytsJ fabG-3 fabG-3 malS malS spsK spsK spsJ spsJ yhjJ yhjJ licH licH galE galE yxjF yxjF gdh-2 gdh-2 idh idh yxnA yxnA gntZ gntZ yycR yycR yhxD yhxD yhxC yhxC yhfP yhfP ycdF ycdF ldh ldh gdh gdh mtlD mtlD ydaD ydaD rex rex gutB gutB ydjL ydjL lplD lplD yfnG yfnG yfjR yfjR malA malA yfhF yfhF fabL fabL ytcA ytcA yhfK yhfK yheG yheG yhdF yhdF ykuF ykuF ykwC ykwC proG proG uxaB uxaB yjmF yjmF yjmD yjmD fabI fabI yjbQ yjbQ argC argC yisS yisS hom hom dhbA dhbA ald ald
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AMK73705.13-ketoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
fadN3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (789 aa)
yqjIPhosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (469 aa)
bcdLeucine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
bkdRAAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (692 aa)
AMK72885.13-hydroxybutyryl-CoA dehydrogenase; Converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
proIPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (278 aa)
yqjQOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
mleANAD-dependent malic enzyme 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
serAD-3-phosphoglycerate dehydrogenase; Catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa)
gudBGlutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (345 aa)
tyrAPrephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
kduD2-deoxy-D-gluconate 3-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
AMK72641.1Capsule biosynthesis protein CapD; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
fabG-23-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (238 aa)
yogAAlcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
yneTCoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (347 aa)
fabG3-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa)
spoVFADipicolinate synthase subunit A; Catalyzes the synthesis of dipicolinic acid from dihydroxydipicolinic acid; plays a role in spore heat resistance; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (383 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
fabG-4beta-ketoacyl-ACP reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
ylnFPrecorrin-2 dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
ylbQ2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (298 aa)
ykqBPotassium transporter Trk; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
ykpB2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa)
yvrDOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
yvaAOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
yvaG3-oxoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
yveMHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (598 aa)
yvcTD-glycerate dehydrogenase; Catalyzes the formation of glycolate from glyoxylate and glycerate from hydroxypyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
tuaDUDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
ywqFHypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
ywnBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
ywkAMalic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
ywfHBacilysin biosynthesis protein BacA; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
ywfDOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
rocGGlutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
comERCompetence protein; May be involved in regulation of competence genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
yueDShort-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
AMK73533.1Potassium channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
yuxGShort-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (689 aa)
yulFOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
yuaAPotassium transporter Trk; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
ytcBUDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
AMK73418.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
melAAlpha-glucosidase/alpha-galactosidase; Catalyses the hydrolysis of terminal non-reducing alpha-D-galactose residues in alpha-D-galactosides; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
aroDShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa)
yqeC6-phosphogluconate dehydrogenase; Similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
adhBGlutathione-dependent formaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
adhAGamma-carboxymuconolactone decarboxylase; Incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
yrbEInositol 2-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (455 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa)
gapBGlyceraldehyde-3-phosphate dehydrogenase; NAD-dependent; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; active during glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
ytsJMalate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
fabG-33-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
malSMalic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
spsKNAD(P)-dependent oxidoreductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (283 aa)
spsJdTDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
yhjJNTD biosynthesis operon oxidoreductase NtdC; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
licH6-phospho-beta-glucosidase; Catalyzes the fromation of N-acetyl-D-glucosamine and N-acetyl-D-glucosamine-6-phosphate from diacetylchitobiose-6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
galEUDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (339 aa)
yxjFCatalyzes the formation of acetoacetate from 3-hydroxybutyrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
gdh-23-oxoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
idhInositol 2-dehydrogenase; Involved in the oxidation of myo-inositol (MI) and D-chiro- inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D- chiro-inositol (1KDCI), respectively. (344 aa)
yxnAOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (356 aa)
gntZPhosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
yycRAldehyde dismutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
yhxDNAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
yhxC(2Fe-2S)-binding protein; Frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
yhfPQuinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
ycdFAspartate phosphatase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
ldhAlpha-amylase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (321 aa)
gdhSugar dehydrogenase; Converts glucose to D-glucono-1,5 lactone; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
ydaDNAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
rexRedox-sensing transcriptional repressor Rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (215 aa)
gutBAlcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
ydjLButanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
lplDAlpha-glucosidase/alpha-galactosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
yfnGSugar dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
yfjR6-phosphogluconate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
malA6-phospho-alpha-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
yfhFEpimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
fabLenoyl-ACP reductase; Catalyzes a key regulatory step in fatty acid biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
ytcAUDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
yhfKSugar epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
yheGHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
yhdFNAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
ykuFShort-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ykwCOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
proGPyrroline-5-carboxylate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
uxaBAltronate oxidoreductase; Catalyzes the formation of D-tagaturonate from D-altronate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannitol dehydrogenase family. UxaB subfamily. (480 aa)
yjmFConverts D-mannonate to D-mannuronate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (278 aa)
yjmDAlcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
fabIenoyl-ACP reductase; Catalyzes a key regulatory step in fatty acid biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
yjbQSodium:proton antiporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (614 aa)
argCMFS transporter; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa)
yisSOxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
homHomoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
dhbA2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
aldAlanine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AlaDH/PNT family. (378 aa)
Your Current Organism:
Bacillus subtilis natto
NCBI taxonomy Id: 86029
Other names: B. subtilis subsp. natto, Bacillus subtilis subsp. natto, Bacillus subtilis var. natto
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