(19 nodes) Terpenoid backbone biosynthesis network (Pyrenophora teres)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	PTT_05307	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (480 aa)
	PTT_07524	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1167 aa)
	PTT_07872	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (398 aa)
	PTT_08014	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (548 aa)
	PTT_08283	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (394 aa)
	PTT_09135	Uncharacterized protein. (347 aa)
	PTT_09671	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (418 aa)
	PTT_11298	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (347 aa)
	PTT_11734	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (433 aa)
	PTT_12236	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (484 aa)
	PTT_12890	Prenylcys_lyase domain-containing protein. (516 aa)
	PTT_13196	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	PTT_13677	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (457 aa)
	PTT_13690	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (385 aa)
	PTT_13928	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (467 aa)
	PTT_14555	Uncharacterized protein. (352 aa)
	PTT_15622	Nudix hydrolase domain-containing protein. (265 aa)
	PTT_18673	Uncharacterized protein. (340 aa)
	PTT_19071	Alkyl transferase; Belongs to the UPP synthase family. (360 aa)

Your Current Organism:

Pyrenophora teres

NCBI taxonomy Id: 861557
Other names: P. teres f. teres 0-1, Pyrenophora teres f. teres 0-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PTT_05307	PTT_07524	E3REY8	E3RHV0	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.542
PTT_05307	PTT_08283	E3REY8	E3RJF9	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.931
PTT_05307	PTT_09135	E3REY8	E3RLA9	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein.	0.933
PTT_05307	PTT_09671	E3REY8	E3RMI9	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.931
PTT_05307	PTT_11298	E3REY8	E3RR86	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.958
PTT_05307	PTT_12236	E3REY8	E3RTB8	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.963
PTT_05307	PTT_12890	E3REY8	E3RUV0	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Prenylcys_lyase domain-containing protein.	0.647
PTT_05307	PTT_13690	E3REY8	E3RWL4	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.944
PTT_05307	PTT_14555	E3REY8	E3RYE2	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein.	0.999
PTT_05307	PTT_18673	E3REY8	E3S796	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein.	0.985
PTT_05307	PTT_19071	E3REY8	E3S849	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Alkyl transferase; Belongs to the UPP synthase family.	0.955
PTT_07524	PTT_05307	E3RHV0	E3REY8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.542
PTT_07524	PTT_07872	E3RHV0	E3RIJ9	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.733
PTT_07524	PTT_08014	E3RHV0	E3RIW3	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.991
PTT_07524	PTT_08283	E3RHV0	E3RJF9	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.520
PTT_07524	PTT_09135	E3RHV0	E3RLA9	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.473
PTT_07524	PTT_09671	E3RHV0	E3RMI9	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.520
PTT_07524	PTT_11298	E3RHV0	E3RR86	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.715
PTT_07524	PTT_13196	E3RHV0	E3RVJ9	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.629
PTT_07524	PTT_13677	E3RHV0	E3RWK1	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999