STRINGSTRING
acpP acpP fabF fabF nodN nodN dxr dxr ppdK ppdK fabHA fabHA pfp pfp ispE ispE coaBC coaBC ach ach EFM02699.1 EFM02699.1 fabF2 fabF2 acpP2 acpP2 fabF3 fabF3 acpP-2 acpP-2 fabF4 fabF4 fabG fabG hutH hutH fabD fabD mutA mutA fabH2 fabH2 EFM02514.1 EFM02514.1 pgk pgk aroE aroE fabH3 fabH3 EFM02380.1 EFM02380.1 pyk pyk fabG-2 fabG-2 EFM02212.1 EFM02212.1 EFM02229.1 EFM02229.1 ispH ispH EFM01998.1 EFM01998.1 fabZ fabZ EFM02029.1 EFM02029.1 pfkA pfkA panB panB EFM01908.1 EFM01908.1 pgi pgi ispD ispD EFM01757.1 EFM01757.1 hutI hutI hutH-2 hutH-2 hutU hutU ftcD ftcD ispF ispF fahA fahA ispD-2 ispD-2 EFM01606.1 EFM01606.1 fabG3 fabG3 EFM01610.1 EFM01610.1 ispG ispG acp acp lipA lipA eno eno fadD fadD gpm gpm fba fba acsA acsA EFM01161.1 EFM01161.1 EFM01179.1 EFM01179.1 EFM01180.1 EFM01180.1 EFM01054.1 EFM01054.1 tpiA tpiA panD panD panC panC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa)
fabFBeta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (420 aa)
nodNMaoC-like protein; COG: COG2030; Pfam: PF01575; InterPro: IPR002539. (154 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (387 aa)
ppdKPyruvate, phosphate dikinase; COG: COG0574; Pfam: PF01326,PF00391,PF02896; InterPro: IPR010121; Belongs to the PEP-utilizing enzyme family. (907 aa)
fabHABeta-ketoacyl-acyl-carrier-protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (338 aa)
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (546 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (279 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa)
achSuccinate CoA transferase; COG: COG0427; Pfam: PF02550; InterPro: IPR003702. (502 aa)
EFM02699.1Hypothetical protein. (123 aa)
fabF2Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR016038; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (577 aa)
acpP2Putative acyl carrier protein; COG: COG0236. (85 aa)
fabF3Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR016038; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (571 aa)
acpP-2Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (81 aa)
fabF4Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (404 aa)
fabGOxidoreductase, short chain dehydrogenase/reductase family protein; COG: COG1028; Pfam: PF00106; InterPro: IPR016040. (242 aa)
hutHPhenylalanine and histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR001106. (504 aa)
fabD[acyl-carrier-protein] S-malonyltransferase; COG: COG0331; Pfam: PF00698; InterPro: IPR001227. (298 aa)
mutAmethylmalonyl-CoA mutase, small subunit; COG: COG1884; Pfam: PF01642; InterPro: IPR004608. (618 aa)
fabH23-oxoacyl-(acyl carrier protein) synthase III. (87 aa)
EFM02514.1AMP-binding enzyme; COG: COG1022; Pfam: PF00501; InterPro: IPR000873. (587 aa)
pgkPhosphoglycerate kinase; COG: COG0126; Pfam: PF00162; InterPro: IPR001576; Belongs to the phosphoglycerate kinase family. (416 aa)
aroEPutative shikimate dehydrogenase; COG: COG0169; Pfam: PF08501,PF01488; InterPro: IPR016040. (248 aa)
fabH3Putative 3-oxoacyl-(acyl carrier protein) synthase III. (214 aa)
EFM02380.13-oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal domain protein; Pfam: PF08541. (161 aa)
pykPyruvate kinase; COG: COG0469; Pfam: PF00224,PF02887; InterPro: IPR001697; Belongs to the pyruvate kinase family. (482 aa)
fabG-23-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)
EFM02212.1Acyl-ACP thioesterase; Pfam: PF01643; InterPro: IPR002864. (256 aa)
EFM02229.1Hypothetical protein. (556 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (287 aa)
EFM01998.1Hypothetical protein. (585 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (464 aa)
EFM02029.1Hypothetical protein. (359 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa)
EFM01908.1Metallo-beta-lactamase domain protein; COG: COG0491; Pfam: PF00753; InterPro: IPR001279. (214 aa)
pgiGlucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. (452 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (241 aa)
EFM01757.1Hypothetical protein; COG: COG0623; InterPro: IPR014358; 1.3.1.9. (292 aa)
hutIImidazolonepropionase; COG: COG1228; Pfam: PF01979; InterPro: IPR005920. (415 aa)
hutH-2Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921. (491 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (664 aa)
ftcDGlutamate formimidoyltransferase; COG: COG3643; Pfam: PF07837,PF02971,PF04961; InterPro: IPR004227. (567 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (165 aa)
fahAFAH family protein; COG: COG0179; Pfam: PF01557; InterPro: IPR011234. (205 aa)
ispD-22-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (263 aa)
EFM01606.1MaoC-like protein; Pfam: PF01575. (140 aa)
fabG3Oxidoreductase, short chain dehydrogenase/reductase family protein; COG: COG1028; Pfam: PF00106; InterPro: IPR016040. (245 aa)
EFM01610.1Hypothetical protein. (83 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (620 aa)
acpPutative acyl carrier protein; InterPro: IPR009081. (85 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (304 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (435 aa)
fadDAMP-binding enzyme; COG: COG1022; Pfam: PF00501; InterPro: IPR000873. (602 aa)
gpmPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (229 aa)
fbaFructose-1,6-bisphosphate aldolase, class II; COG: COG0191; Pfam: PF01116; InterPro: IPR000771. (336 aa)
acsAAMP-binding enzyme; COG: COG0365; Pfam: PF00501; InterPro: IPR000873. (552 aa)
EFM01161.1Hypothetical protein; COG: COG3681; Pfam: PF06354; InterPro: IPR010469; Belongs to the UPF0597 family. (430 aa)
EFM01179.1Putative iron-sulfur cluster-binding protein; COG: COG1139; Pfam: PF02589,PF00037; InterPro: IPR012285. (457 aa)
EFM01180.1Hypothetical protein; Pfam: PF02589; InterPro: IPR003741. (199 aa)
EFM01054.1Hypothetical protein. (567 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (115 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa)
Your Current Organism:
Prevotella marshii
NCBI taxonomy Id: 862515
Other names: P. marshii DSM 16973 = JCM 13450, Prevotella marshii DSM 16973, Prevotella marshii DSM 16973 = DSM 16973, Prevotella marshii DSM 16973 = JCM 13450, Prevotella marshii E9.34, Prevotella marshii JCM 13450
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