STRINGSTRING
AZOLI_0116 AZOLI_0116 aroA aroA argJ argJ argF argF argD argD pheA pheA AZOLI_0344 AZOLI_0344 dapE dapE dapD dapD AZOLI_0363 AZOLI_0363 argB argB AZOLI_0515 AZOLI_0515 dapF dapF thrC thrC aroQ aroQ trpE trpE trpC trpC trpD trpD trpG trpG dapA dapA asd2 asd2 AZOLI_1200 AZOLI_1200 trpEG trpEG thrB thrB hom hom dapL dapL hisC2 hisC2 hisI hisI hisE2 hisE2 hisE3 hisE3 aroC aroC asd1 asd1 trpF trpF argG argG aatA aatA lysC lysC AZOLI_2891 AZOLI_2891 trpA trpA trpB trpB aroK aroK aroB aroB aroE aroE AZOLI_3046 AZOLI_3046 hisB hisB hisH1 hisH1 AZOLI_3050 AZOLI_3050 hisA hisA hisF1 hisF1 hisE1 hisE1 AZOLI_3054 AZOLI_3054
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AZOLI_0116Asparaginase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (361 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (458 aa)
argJArginine biosynthesis bifunctional protein ArgJ alpha chain; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (412 aa)
argFOrnithine carbamoyltransferase (OTCase); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (317 aa)
argDBifunctional: acetylornithine aminotransferase and succinyldiaminopimelate; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (385 aa)
pheAPrephenate dehydratase; Function of strongly homologous gene; enzyme. (288 aa)
AZOLI_03442-oxo/hydroxy acid reductase; Function of strongly homologous gene; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
dapESuccinyl-diaminopimelate desuccinylase (SDAP); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (382 aa)
dapDTetrahydrodipicolinate N-succinyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the transferase hexapeptide repeat family. (280 aa)
AZOLI_0363Putative pyrimidine 5-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (239 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa)
AZOLI_0515Putative N-formylglutamate amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (288 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (283 aa)
thrCThreonine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (473 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (503 aa)
trpCIndole-3-glycerol-phosphate synthase; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the TrpC family. (267 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
trpGAminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (202 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa)
asd2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa)
AZOLI_1200N-formylglutamate amidohydrolase; Function of strongly homologous gene; enzyme. (274 aa)
trpEGAnthranilate synthase [Includes: Glutamine amidotransferase]; Function of strongly homologous gene; enzyme. (753 aa)
thrBHomoserine kinase; Function of strongly homologous gene; enzyme; Belongs to the pseudomonas-type ThrB family. (327 aa)
homHomoserine dehydrogenase (HDH); Function of strongly homologous gene; enzyme. (434 aa)
dapLLL-diaminopimelate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (424 aa)
hisC2Histidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (144 aa)
hisE2Transposase of ISAli9, IS5 family subgroup IS427, ORFB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (129 aa)
hisE3phosphoribosyl-ATP pyrophosphatase; Function experimentally demonstrated in the studied genus; enzyme. (108 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa)
asd1Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Function of strongly homologous gene; enzyme; Belongs to the TrpF family. (214 aa)
argGArgininosuccinate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (411 aa)
aatATransposase of ISAli3, IS630 family. ORFB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (400 aa)
lysCAspartokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartokinase family. (411 aa)
AZOLI_2891Putative polyphenol oxidase (tyrosinase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (556 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (281 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (224 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (381 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (298 aa)
AZOLI_3046Homologs of previously reported genes of unknown function. (535 aa)
hisBImidazoleglycerol-phosphate dehydratase; Function experimentally demonstrated in the studied genus; enzyme. (220 aa)
hisH1Imidazole glycerol phosphate synthase, HisH subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (214 aa)
AZOLI_3050Putative GCN5 N-acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (180 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase; Function experimentally demonstrated in the studied genus; enzyme. (248 aa)
hisF1Imidazole glycerol phosphate synthase, HisF subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (265 aa)
hisE1Phosphoribosyl-ATP pyrophosphatase; Function experimentally demonstrated in the studied genus; enzyme. (119 aa)
AZOLI_3054Homologs of previously reported genes of unknown function. (122 aa)
Your Current Organism:
Azospirillum lipoferum
NCBI taxonomy Id: 862719
Other names: A. lipoferum 4B, Azospirillum lipoferum 4B, Azospirillum lipoferum str. 4B, Azospirillum lipoferum strain 4B
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.