STRINGSTRING
AEN09175.1 AEN09175.1 AEN09144.1 AEN09144.1 AEN09087.1 AEN09087.1 AEN09031.1 AEN09031.1 AEN09008.1 AEN09008.1 AEN08969.1 AEN08969.1 AEN08903.1 AEN08903.1 AEN08864.1 AEN08864.1 ruvC ruvC AEN08832.1 AEN08832.1 AEN08733.1 AEN08733.1 AEN08694.1 AEN08694.1 sbcD sbcD rnhA rnhA AEN08217.1 AEN08217.1 AEN08004.1 AEN08004.1 AEN07996.1 AEN07996.1 AEN10024.1 AEN10024.1 orn orn AEN10229.1 AEN10229.1 AEN10247.1 AEN10247.1 AEN10265.1 AEN10265.1 AEN10266.1 AEN10266.1 rph rph AEN10273.1 AEN10273.1 AEN10274.1 AEN10274.1 AEN10500.1 AEN10500.1 AEN10521.1 AEN10521.1 AEN10746.1 AEN10746.1 AEN10747.1 AEN10747.1 AEN10930.1 AEN10930.1 AEN10992.1 AEN10992.1 AEN10994.1 AEN10994.1 AEN11151.1 AEN11151.1 AEN11173.1 AEN11173.1 rnpA rnpA AEN11228.1 AEN11228.1 AEN11321.1 AEN11321.1 AEN11345.1 AEN11345.1 AEN11486.1 AEN11486.1 xseB xseB xseA xseA AEN12145.1 AEN12145.1 AEN12225.1 AEN12225.1 AEN12228.1 AEN12228.1 AEN12246.1 AEN12246.1 AEN12247.1 AEN12247.1 AEN12366.1 AEN12366.1 nucS nucS rnc rnc AEN12647.1 AEN12647.1 rnj rnj rnhB rnhB AEN13000.1 AEN13000.1 AEN13072.1 AEN13072.1 AEN13135.1 AEN13135.1 AEN13205.1 AEN13205.1 AEN13232.1 AEN13232.1 AEN13347.1 AEN13347.1 AEN13452.1 AEN13452.1 AEN13662.1 AEN13662.1 nfi nfi AEN13881.1 AEN13881.1 AEN13968.1 AEN13968.1 AEN13980.1 AEN13980.1 AEN13990.1 AEN13990.1 AEN14002.1 AEN14002.1 AEN14291.1 AEN14291.1 AEN12146.1 AEN12146.1 AEN10021.1 AEN10021.1 AEN09982.1 AEN09982.1 AEN09918.1 AEN09918.1 AEN09874.1 AEN09874.1 rnz rnz ybeY ybeY AEN09752.1 AEN09752.1 AEN09698.1 AEN09698.1 AEN09626.1 AEN09626.1 nfo nfo AEN09410.1 AEN09410.1 AEN09408.1 AEN09408.1 polA polA uvrB uvrB uvrA uvrA uvrC uvrC recD2 recD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEN09175.1TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; BRCT domain protein; KEGG: sgr:SGR_5666 DNA polymerase III subunit epsilon; SMART: Exonuclease; BRCT domain protein. (333 aa)
AEN09144.1HNH endonuclease; KEGG: sgr:SGR_5702 putative endonuclease; PFAM: HNH endonuclease; SMART: HNH nuclease. (168 aa)
AEN09087.1DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: sma:SAV_6555 DNA polymerase III alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1154 aa)
AEN09031.1KEGG: sgr:SGR_5832 hypothetical protein. (775 aa)
AEN09008.1KEGG: sgr:SGR_5851 hypothetical protein. (281 aa)
AEN08969.1KEGG: sgr:SGR_5889 putative 5'-3' exonuclease; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2. (329 aa)
AEN08903.1PFAM: ABC transporter related; KEGG: sma:SAV_2097 UvrA-like protein. (796 aa)
AEN08864.1KEGG: sgr:SGR_6000 DNA polymerase III subunit epsilon; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (241 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (177 aa)
AEN08832.1Holliday junction resolvase YqgF; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (154 aa)
AEN08733.1PFAM: protein of unknown function DUF151; KEGG: sma:SAV_6983 hypothetical protein. (157 aa)
AEN08694.1PFAM: Endonuclease/exonuclease/phosphatase; KEGG: sgr:SGR_201 hypothetical protein. (334 aa)
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (388 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (233 aa)
AEN08217.1PFAM: Endonuclease I; KEGG: sgr:SGR_6769 putative secreted ribonuclease. (269 aa)
AEN08004.1KEGG: app:CAP2UW1_4401 hypothetical protein. (478 aa)
AEN07996.1PFAM: Putative endonuclease, Z1 domain; KEGG: sma:SAV_2336 regulatory protein. (1390 aa)
AEN10024.1TIGRFAM: type I site-specific deoxyribonuclease, HsdR family; PFAM: protein of unknown function DUF450; type III restriction protein res subunit; KEGG: cef:CE0259 hypothetical protein; SMART: DEAD-like helicase. (1196 aa)
ornExonuclease RNase T and DNA polymerase III; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (201 aa)
AEN10229.1PFAM: restriction endonuclease; KEGG: rha:RHA1_ro01632 restriction endonuclease. (278 aa)
AEN10247.1PFAM: Excalibur domain protein; KEGG: sgr:SGR_4658 hypothetical protein. (291 aa)
AEN10265.1KEGG: sgr:SGR_4642 hypothetical protein. (218 aa)
AEN10266.1KEGG: sgr:SGR_4641 hypothetical protein. (234 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (245 aa)
AEN10273.1KEGG: sgr:SGR_4634 hypothetical protein. (250 aa)
AEN10274.1Transcriptional modulator of MazE/toxin, MazF; KEGG: sgr:SGR_4633 hypothetical protein. (204 aa)
AEN10500.1Hydrolase, TatD family; KEGG: sgr:SGR_4354 putative deoxyribonuclease; TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease. (288 aa)
AEN10521.1TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; KEGG: sgr:SGR_4310 putative exodeoxyribonuclease; PFAM: Endonuclease/exonuclease/phosphatase. (271 aa)
AEN10746.1KEGG: sgr:SGR_4065 hypothetical protein. (392 aa)
AEN10747.1KEGG: sgr:SGR_4064 putative DNA polymerase I; PFAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase. (568 aa)
AEN10930.1SMART: DNA polymerase III beta chain; TIGRFAM: DNA polymerase III, beta subunit; KEGG: sgr:SGR_3397 DNA polymerase III subunit beta; PFAM: DNA polymerase III beta chain. (373 aa)
AEN10992.1Hypothetical protein; KEGG: csa:Csal_2775 alpha/beta hydrolase. (145 aa)
AEN10994.1KEGG: sgr:SGR_3445 hypothetical protein. (133 aa)
AEN11151.1PFAM: restriction endonuclease; KEGG: sgr:SGR_3632 hypothetical protein. (355 aa)
AEN11173.1DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (123 aa)
AEN11228.1PFAM: metallophosphoesterase; KEGG: sgr:SGR_3649 putative serine/threonine phosphatase. (352 aa)
AEN11321.1KEGG: nfa:nfa50050 hypothetical protein. (141 aa)
AEN11345.1KEGG: cms:CMS_0477 hypothetical protein. (214 aa)
AEN11486.1KEGG: mmi:MMAR_3923 hypothetical protein. (307 aa)
xseBExodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (85 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (413 aa)
AEN12145.1Protein of unknown function DUF450; KEGG: fra:Francci3_0194 hypothetical protein; PFAM: protein of unknown function DUF450; type III restriction protein res subunit; SMART: DEAD-like helicase. (1048 aa)
AEN12225.1PHP domain protein; KEGG: sgr:SGR_2364 hypothetical protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein. (288 aa)
AEN12228.1KEGG: sgr:SGR_2361 hypothetical protein. (303 aa)
AEN12246.1PFAM: UvrD/REP helicase; KEGG: sgr:SGR_2342 putative ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1137 aa)
AEN12247.1PFAM: UvrD/REP helicase; KEGG: sgr:SGR_2341 putative ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1164 aa)
AEN12366.1KEGG: sgr:SGR_2196 hypothetical protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (297 aa)
nucSProtein of unknown function DUF91; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (223 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (274 aa)
AEN12647.1PFAM: protein of unknown function UPF0102; KEGG: sgr:SGR_1878 hypothetical protein; Belongs to the UPF0102 family. (119 aa)
rnjRNA-metabolising metallo-beta-lactamase; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (561 aa)
rnhBRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (236 aa)
AEN13000.1KEGG: sen:SACE_5459 hypothetical protein. (1170 aa)
AEN13072.1Manually curated; PFAM: 3'-5' exonuclease; HRDC domain protein; KEGG: sgr:SGR_1476 putative ribonuclease D; SMART: 3'-5' exonuclease; HRDC domain protein. (424 aa)
AEN13135.1KEGG: sco:SCO6084 DNA polymerase III subunit epsilon; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (243 aa)
AEN13205.1Ribonuclease T(1); KEGG: sgr:SGR_1362 putative guanyl-specific ribonuclease; PFAM: guanine-specific ribonuclease N1 and T1. (145 aa)
AEN13232.1PFAM: Endonuclease/exonuclease/phosphatase; KEGG: sgr:SGR_1342 putative endonuclease/exonuclease/phosphatase family protein. (796 aa)
AEN13347.1Exodeoxyribonuclease III Xth; KEGG: sgr:SGR_1255 putative exonuclease; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (259 aa)
AEN13452.1PFAM: restriction endonuclease; KEGG: sgr:SGR_1168 putative Mrr restriction system protein. (266 aa)
AEN13662.1KEGG: sgr:SGR_1023 hypothetical protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (337 aa)
nfiDeoxyribonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (225 aa)
AEN13881.1KEGG: tcu:Tcur_2031 putative cytoplasmic protein. (156 aa)
AEN13968.1DNA-(apurinic or apyrimidinic site) lyase; KEGG: sgr:SGR_724 putative formamidopyrimidine-DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; DNA glycosylase/AP lyase, H2TH DNA-binding; Belongs to the FPG family. (286 aa)
AEN13980.1KEGG: sgr:SGR_713 hypothetical protein. (205 aa)
AEN13990.1TIGRFAM: excinuclease ABC, A subunit; PFAM: ABC transporter related; KEGG: sgr:SGR_704 putative excinuclease ABC subunit A; SMART: AAA ATPase. (809 aa)
AEN14002.1KEGG: sgr:SGR_693 hypothetical protein. (154 aa)
AEN14291.1PFAM: restriction endonuclease; KEGG: sma:SAV_1059 hypothetical protein. (200 aa)
AEN12146.1KEGG: sgr:SGR_3445 hypothetical protein. (135 aa)
AEN10021.1Hypothetical protein. (75 aa)
AEN09982.1HNH endonuclease; KEGG: sgr:SGR_4876 putative endonuclease; PFAM: HNH endonuclease; SMART: HNH nuclease. (196 aa)
AEN09918.1Ribonuclease, Rne/Rng family; KEGG: sgr:SGR_4940 hypothetical protein; TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA-binding protein AU-1/Ribonuclease E/G. (1430 aa)
AEN09874.1KEGG: sgr:SGR_4991 hypothetical protein. (272 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (302 aa)
ybeYProtein of unknown function UPF0054; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (165 aa)
AEN09752.1HNH endonuclease; KEGG: mlo:mll7993 hypothetical protein; PFAM: HNH endonuclease; SMART: HNH nuclease. (334 aa)
AEN09698.1PFAM: Phosphoglycerate mutase; ribonuclease H; KEGG: sgr:SGR_5214 bifunctional RNase H/acid phosphatase. (413 aa)
AEN09626.1KEGG: sgr:SGR_5226 hypothetical protein. (153 aa)
nfoApurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (293 aa)
AEN09410.1DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: sgr:SGR_5440 DNA polymerase III subunit alpha; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type. (1179 aa)
AEN09408.1PFAM: protein of unknown function DUF88; KEGG: sgr:SGR_5442 hypothetical protein. (415 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (903 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (712 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1006 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (697 aa)
recD2Helicase, RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (751 aa)
Your Current Organism:
Streptomyces sp. SirexAAE
NCBI taxonomy Id: 862751
Other names: S. sp. SirexAA-E, Streptomyces sp. ACTE, Streptomyces sp. SA3_actE, Streptomyces sp. SirexAA-E
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