STRINGSTRING
pyrF pyrF pyrD pyrD carB carB carA carA pyrC pyrC pyrB pyrB pyrR pyrR cmk cmk pyrG pyrG psuG psuG AEN09351.1 AEN09351.1 ndk ndk AEN10093.1 AEN10093.1 AEN10420.1 AEN10420.1 AEN10834.1 AEN10834.1 tmk tmk pyrE pyrE dcd dcd upp upp AEN11441.1 AEN11441.1 AEN11783.1 AEN11783.1 AEN11989.1 AEN11989.1 AEN11990.1 AEN11990.1 AEN12009.1 AEN12009.1 AEN12016.1 AEN12016.1 AEN12135.1 AEN12135.1 AEN12292.1 AEN12292.1 AEN12293.1 AEN12293.1 pyrH pyrH thyX thyX AEN12793.1 AEN12793.1 tdk tdk dut dut AEN13395.1 AEN13395.1 AEN13397.1 AEN13397.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pyrFTIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: sgr:SGR_6053 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (279 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (369 aa)
carBKEGG: sgr:SGR_6051 carbamoyl phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1102 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; KEGG: sgr:SGR_6050 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (380 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
pyrBKEGG: sgr:SGR_6047 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (335 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (194 aa)
cmkKEGG: sgr:SGR_5739 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (250 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (556 aa)
psuGIndigoidine synthase A family protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (319 aa)
AEN09351.12',3'-cyclic-nucleotide 2'-phosphodiesterase; KEGG: sgr:SGR_5514 putative 5'-nucleotidase; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; Twin-arginine translocation pathway, signal sequence, subgroup; Belongs to the 5'-nucleotidase family. (603 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
AEN10093.1KEGG: psb:Psyr_2556 deoxycytidine triphosphate deaminase. (175 aa)
AEN10420.1TIGRFAM: amidase, hydantoinase/carbamoylase family; KEGG: sgr:SGR_4463 allantoate amidohydrolase; PFAM: peptidase M20. (411 aa)
AEN10834.1PFAM: purine or other phosphorylase family 1; KEGG: emi:Emin_0020 purine phosphorylase family 1. (268 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (1023 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (187 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
AEN11441.1PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: sgr:SGR_3941 putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (605 aa)
AEN11783.1PFAM: Amidohydrolase 3; KEGG: sgr:SGR_2885 hypothetical protein. (415 aa)
AEN11989.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
AEN11990.1TIGRFAM: pyrimidine-nucleoside phosphorylase; KEGG: sgr:SGR_2649 thymidine phosphorylase; PFAM: Pyrimidine nucleoside phosphorylase domain; glycosyl transferase family 3; Glycosyl transferase, family 3-like. (425 aa)
AEN12009.1Putative ATP-binding protein; Manually curated; KEGG: sgr:SGR_2633 putative ATP-binding protein. (246 aa)
AEN12016.1Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa)
AEN12135.1PFAM: nitroreductase; KEGG: sgr:SGR_2476 hypothetical protein. (196 aa)
AEN12292.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (340 aa)
AEN12293.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (803 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (258 aa)
thyXThymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (245 aa)
AEN12793.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (971 aa)
tdkKEGG: sma:SAV_2414 thymidine kinase; PFAM: thymidine kinase. (216 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (176 aa)
AEN13395.1PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: sgr:SGR_1233 putative hydrolase. (280 aa)
AEN13397.1Dihydropyrimidinase; KEGG: sma:SAV_1949 phenylhydantoinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (463 aa)
Your Current Organism:
Streptomyces sp. SirexAAE
NCBI taxonomy Id: 862751
Other names: S. sp. SirexAA-E, Streptomyces sp. ACTE, Streptomyces sp. SA3_actE, Streptomyces sp. SirexAA-E
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