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| | dapL | Putative L,L-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (410 aa) |
| | MTCT_0084 | Putative ATP phosphoribosyltransferase. (328 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (399 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | MTCT_0151 | 3-isopropylmalate dehydrogenase. (329 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (259 aa) |
| | hisS | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (427 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (112 aa) |
| | argH | Argininosuccinate lyase. (478 aa) |
| | MTCT_0413 | Thiamine pyrophosphate; Belongs to the TPP enzyme family. (581 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (221 aa) |
| | MTCT_0500 | Conserved hypothetical protein. (166 aa) |
| | cimA | 2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (496 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (367 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (419 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | MTCT_0718 | Aspartate kinase; Belongs to the aspartokinase family. (406 aa) |
| | MTCT_0720 | Chorismate mutase. (98 aa) |
| | aroK | Putative shikimate kinase. (286 aa) |
| | hacB | 3-isopropylmalate dehydratase; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD ty [...] (182 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (246 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase. (96 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (289 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (428 aa) |
| | argD | N-acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (278 aa) |
| | leuC | 3-isopropylmalate dehydratase LeuD subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa) |
| | leuD | 3-isopropylmalate dehydratase LeuC subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | MTCT_1261 | 3-isopropylmalate dehydrogenase. (326 aa) |
| | ilvE | Aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa) |
| | MTCT_1311 | Acetolactate synthase regulatory subunit. (165 aa) |
| | MTCT_1312 | Acetolactate synthase catalytic subunit. (574 aa) |
| | MTCT_1314 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (549 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (187 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (428 aa) |
| | MTCT_1345 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (366 aa) |
| | MTCT_1461 | Thiamine pyrophosphate; Belongs to the TPP enzyme family. (522 aa) |
| | MTCT_1485 | Phosphoserine phosphatase. (491 aa) |
| | MTCT_1489 | Trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | MTCT_1497 | Prephenate dehydrogenase. (442 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (472 aa) |
| | MTCT_1511 | Anthranilate synthase component II. (194 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (272 aa) |
| | trpF | 5'-phosphoribosyl anthranilate isomerase; Belongs to the TrpF family. (241 aa) |
| | trpB-2 | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (392 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa) |
