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MTCT_0413 MTCT_0413 cimA cimA leuC leuC leuD leuD MTCT_1261 MTCT_1261 ilvE ilvE ilvC ilvC MTCT_1311 MTCT_1311 MTCT_1312 MTCT_1312 ilvD ilvD MTCT_1345 MTCT_1345 MTCT_1461 MTCT_1461
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTCT_0413Thiamine pyrophosphate; Belongs to the TPP enzyme family. (581 aa)
cimA2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (496 aa)
leuC3-isopropylmalate dehydratase LeuD subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa)
leuD3-isopropylmalate dehydratase LeuC subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa)
MTCT_12613-isopropylmalate dehydrogenase. (326 aa)
ilvEAminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
MTCT_1311Acetolactate synthase regulatory subunit. (165 aa)
MTCT_1312Acetolactate synthase catalytic subunit. (574 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (549 aa)
MTCT_13452-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa)
MTCT_1461Thiamine pyrophosphate; Belongs to the TPP enzyme family. (522 aa)
Your Current Organism:
Methanothermobacter sp. CaT2
NCBI taxonomy Id: 866790
Other names: M. sp. CaT2
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