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MTCT_1261 MTCT_1261 guaB guaB MTCT_0151 MTCT_0151 MTCT_0154 MTCT_0154 hisD hisD MTCT_0197 MTCT_0197 aroE aroE gpsA gpsA MTCT_0358 MTCT_0358 MTCT_0489 MTCT_0489 egsA egsA MTCT_0750 MTCT_0750 MTCT_0881 MTCT_0881 ilvC ilvC MTCT_0894 MTCT_0894 MTCT_1098 MTCT_1098 MTCT_1124 MTCT_1124
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTCT_12613-isopropylmalate dehydrogenase. (326 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
MTCT_01513-isopropylmalate dehydrogenase. (329 aa)
MTCT_0154Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (325 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa)
MTCT_0197Putative 5-amino-6-(5-phosphoribosylamino) uracil reductase. (216 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (259 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (321 aa)
MTCT_0358Homoserine dehydrogenase. (337 aa)
MTCT_04893-hydroxy-3-methylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family. (397 aa)
egsANAD(P)-dependent glycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (347 aa)
MTCT_0750UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (431 aa)
MTCT_0881Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
MTCT_0894Alcohol dehydrogenase. (406 aa)
MTCT_1098Malate dehydrogenase. (341 aa)
MTCT_1124Homoserine dehydrogenase. (423 aa)
Your Current Organism:
Methanothermobacter sp. CaT2
NCBI taxonomy Id: 866790
Other names: M. sp. CaT2
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