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| | MTCT_1588 | Pyruvate ferredoxin oxidoreductase beta subunit. (288 aa) |
| | MTCT_1728 | NTPase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (175 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (166 aa) |
| | MTCT_1702 | Phosphoribosylformylglycinamidine synthase. (328 aa) |
| | MTCT_1699 | Molybdenum cofactor biosynthesis MoaB. (176 aa) |
| | pyrE | Uridine 5'-monophosphate synthase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (181 aa) |
| | MTCT_1691 | Indolepyruvate oxidoreductase beta subunit. (196 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (197 aa) |
| | MTCT_1672 | Quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (279 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa) |
| | MTCT_1663 | Conserved hypothetical protein. (146 aa) |
| | tmk | Thymidylate kinase. (194 aa) |
| | MTCT_1591 | Truncated indolepyruvate ferredoxin oxidoreductase. (177 aa) |
| | MTCT_1590 | Truncated indolepyruvate ferredoxin oxidoreductase. (81 aa) |
| | MTCT_1589 | Pyruvate ferredoxin oxidoreductase alpha subunit. (383 aa) |
| | MTCT_1570 | Putative geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (385 aa) |
| | cdhE | acetyl-CoA decarbonylase/synthase complex gamma subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (458 aa) |
| | cdhC | acetyl-CoA decarbonylase/synthase complex beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (460 aa) |
| | cdhA | acetyl-CoA decarbonylase/synthase complex alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (777 aa) |
| | MTCT_1543 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (195 aa) |
| | thiI | Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (389 aa) |
| | MTCT_1488 | Putative adenylate cyclase. (177 aa) |
| | thi4 | Putative thiazole biosynthetic protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (266 aa) |
| | MTCT_1478 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (171 aa) |
| | dut | Deoxycytidine-triphosphate deaminase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (149 aa) |
| | MTCT_1462 | acetyl-CoA synthetase. (653 aa) |
| | mptE | Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (232 aa) |
| | apgM-2 | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (409 aa) |
| | thiC-2 | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa) |
| | MTCT_1416 | Molybdopterin-guanine dinucleotide biosynthesis protein B. (233 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (294 aa) |
| | fdhD | Formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (248 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (430 aa) |
| | MTCT_1402 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (449 aa) |
| | nadE | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (256 aa) |
| | MTCT_1364 | Conserved hypothetical protein. (122 aa) |
| | MTCT_1356 | 5'-nucleotidase. (474 aa) |
| | purD | Glycinamide ribonucleotide synthetase; Belongs to the GARS family. (437 aa) |
| | surE | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa) |
| | MTCT_1295 | Nucleoside triphosphate phosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (187 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit. (312 aa) |
| | thiL | Thiamine monphosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (334 aa) |
| | MTCT_1253 | Flavoprotein. (236 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (714 aa) |
| | MTCT_1243 | Molybdenum cofactor biosynthesis MoeA. (404 aa) |
| | MTCT_1212 | Putative NUDIX hydrolase. (130 aa) |
| | hpt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (193 aa) |
| | MTCT_1168 | Conserved hypothetical protein. (249 aa) |
| | nnrE | Carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (500 aa) |
| | MTCT_1131 | Putative NADH dehydrogenase. (148 aa) |
| | MTCT_1108 | Flavoprotein. (393 aa) |
| | pyrD | Dihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate. (300 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (263 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase. (338 aa) |
| | purP | 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranosyl 5'-monophosphate--formate ligase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (363 aa) |
| | mptA | Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (318 aa) |
| | MTCT_1072 | Phosphoesterase. (350 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa) |
| | mfnA | Glutamate decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (385 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | MTCT_0999 | Myo-inositol-1-phosphate synthase. (365 aa) |
| | MTCT_0995 | Putative metallo-beta-lactamase. (260 aa) |
| | MTCT_0992 | Prenyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (295 aa) |
| | MTCT_0990 | Metallo-beta-lactamase. (449 aa) |
| | MTCT_0969 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (174 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (406 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa) |
| | MTCT_0943 | 2-oxoglutarate ferredoxin oxidoreductase gamma subunit. (186 aa) |
| | mptD | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (121 aa) |
| | MTCT_0935 | CDP-diacylglycerol-serine O-phosphatidyltransferase. (219 aa) |
| | asd-2 | Phosphatidylserine decarboxylase; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily. (224 aa) |
| | purO | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (202 aa) |
| | cofE | F420-0--gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (252 aa) |
| | cofD | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa) |
| | MTCT_0923 | ABC transporter ATP-binding subunit. (540 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase. (337 aa) |
| | MTCT_0911 | Molybdenum cofactor biosynthesis protein MoeA. (408 aa) |
| | carA | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (360 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1059 aa) |
| | MTCT_0893 | Conserved hypothetical protein. (159 aa) |
| | MTCT_0889 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (470 aa) |
| | nadX | L-aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (254 aa) |
| | atpE | V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (206 aa) |
| | atpC | V-type ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (385 aa) |
| | atpF | V-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (106 aa) |
| | atpA | V-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (584 aa) |
| | atpB | V-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | pyrH | Uridine monophosphate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (224 aa) |
| | MTCT_0794 | Orotate phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (202 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (282 aa) |
| | MTCT_0789 | Inositol-1 monophosphatase/fructose-1,6-bisphosphatase. (280 aa) |
| | MTCT_0777 | Phosphomethylpyrimidine kinase. (184 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa) |
| | ribL | Glycerol-3-phosphate cytidyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (151 aa) |
| | carS | Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (149 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (221 aa) |
| | moaC | Putative molybdenum cofactor biosynthesis protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (156 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (285 aa) |
| | thyA | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (227 aa) |
| | MTCT_0647 | Conserved hypothetical protein. (375 aa) |
| | guaAB | GMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (308 aa) |
| | guaAA | GMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. (184 aa) |
| | MTCT_0630 | acetyl-CoA synthetase. (559 aa) |
| | MTCT_0626 | Flavoprotein. (190 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa) |
| | MTCT_0587 | Putative transcriptional regulator. (190 aa) |
| | arfB | Creatininase; Catalyzes the hydrolysis of the formamide of 2-amino-5- formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy). (233 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (468 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (340 aa) |
| | cofC | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (223 aa) |
| | egsA | NAD(P)-dependent glycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (347 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa) |
| | MTCT_0501 | Conserved hypothetical protein. (292 aa) |
| | MTCT_0489 | 3-hydroxy-3-methylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family. (397 aa) |
| | MTCT_0480 | Putative geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (245 aa) |
| | MTCT_0401 | Conserved hypothetical protein. (289 aa) |
| | MTCT_0375 | Conserved hypothetical protein. (248 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | apgM | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (399 aa) |
| | MTCT_0342 | Formate hydrogenlyase large subunit. (370 aa) |
| | MTCT_0311 | Putative UDP-N-acetylglucosamine pyrophosphorylase. (231 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (321 aa) |
| | MTCT_0239 | Putative FAD-dependent dehydrogenase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (394 aa) |
| | MTCT_0238 | Prenyltransferase. (260 aa) |
| | MTCT_0229 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (162 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (150 aa) |
| | cpgS | Putative 2,3-diphosphoglycerate synthase; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (462 aa) |
| | MTCT_0179 | acetyl-CoA synthetase. (634 aa) |
| | pdxT | Putative glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (192 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (248 aa) |
| | MTCT_0135 | Phosphoribosylformylglycinamidine synthase subunit PurS. (81 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (216 aa) |
| | MTCT_0115 | Nicotinamide-nucleotide adenylyltransferase. (175 aa) |
| | MTCT_0114 | Molybdenum cofactor biosynthesis protein. (143 aa) |
| | MTCT_0113 | Putative phosphohydrolase. (406 aa) |
| | mobA | Putative molybdopterin-guanine dinucleotide biosynthesis protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (199 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa) |
| | pyrF | Orotidine 5' monophosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (217 aa) |
| | MTCT_0087 | Putative NUDIX hydrolase. (151 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (305 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa) |
| | cmk | Cytidylate kinase. (172 aa) |
| | adkA | Adenylate kinase; Belongs to the archaeal adenylate kinase family. (185 aa) |
