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priL priL MTCT_1654 MTCT_1654 MTCT_1548 MTCT_1548 rpl12 rpl12 rpl10 rpl10 rpl1 rpl1 rpl11 rpl11 spt5 spt5 topA topA rps19e rps19e rpl39e rpl39e rpl31e rpl31e rpl18a rpl18a MTCT_1458 MTCT_1458 rps3ae rps3ae MTCT_1362 MTCT_1362 albA albA rps15 rps15 MTCT_1284 MTCT_1284 rpl21e rpl21e rpl44e rpl44e rps27e rps27e MTCT_1102 MTCT_1102 MTCT_1101 MTCT_1101 rpl10e rpl10e MTCT_0987 MTCT_0987 rps10 rps10 rps7 rps7 rps12 rps12 rpl30e rpl30e top6A top6A top6B top6B MTCT_0914 MTCT_0914 dnaG dnaG MTCT_0771 MTCT_0771 MTCT_0737 MTCT_0737 rps17e rps17e MTCT_0691 MTCT_0691 rpl15e rpl15e MTCT_0614 MTCT_0614 rpl37ae rpl37ae MTCT_0608 MTCT_0608 rpl37e rpl37e MTCT_0516 MTCT_0516 MTCT_0001 MTCT_0001 rpl3 rpl3 rpl4 rpl4 rpl23 rpl23 rpl2 rpl2 rps19p rps19p rpl22 rpl22 rps3 rps3 rpl29 rpl29 MTCT_0012 MTCT_0012 rpl14 rpl14 rpl24 rpl24 rps4e rps4e rpl5 rpl5 rps14 rps14 rps8 rps8 rpl6 rpl6 MTCT_0020 MTCT_0020 rpl19e rpl19e rpl18 rpl18 rps5 rps5 rpl30 rpl30 rpl15 rpl15 rpl34e rpl34e rpl14e rpl14e rps13 rps13 rps4 rps4 rps11 rps11 rpl18e rpl18e rpl13 rpl13 rps9 rps9 rps2 rps2 rps8e rps8e MTCT_0171 MTCT_0171 rfcL rfcL rfcS rfcS MTCT_0217 MTCT_0217 rpl7ae rpl7ae rps28e rps28e rpl24e rpl24e rps6e rps6e MTCT_0225 MTCT_0225 rps24e rps24e rps27ae rps27ae MTCT_0379 MTCT_0379 MTCT_0438 MTCT_0438 mre11 mre11 rpl40e rpl40e priS priS MTCT_0515 MTCT_0515
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (434 aa)
MTCT_1654ATPase. (285 aa)
MTCT_1548Histone-like transcriptional factor. (68 aa)
rpl1250S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (102 aa)
rpl10Acidic ribosomal protein P0; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (336 aa)
rpl150S ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
rpl1150S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (160 aa)
spt5Transcription antitermination protein NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (159 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (711 aa)
rps19e30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
rpl39e50S ribosomal protein L39e; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
rpl31e50S ribosomal protein L31e; Belongs to the ribosomal protein L31e family. (81 aa)
rpl18a50S ribosomal protein LX. (76 aa)
MTCT_1458Cell division control protein; Involved in regulation of DNA replication. (379 aa)
rps3ae30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family. (195 aa)
MTCT_1362Conserved hypothetical protein. (219 aa)
albAChromatin protein; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (91 aa)
rps1530S ribosomal protein S15P. (133 aa)
MTCT_1284Cell division control protein; Involved in regulation of DNA replication. (382 aa)
rpl21e50S ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa)
rpl44e50S ribosomal protein L44e; Binds to the 23S rRNA. (92 aa)
rps27e30S ribosomal protein S27e. (60 aa)
MTCT_1102Restriction endonuclease. (307 aa)
MTCT_1101DNA-dependent DNA polymerase. (581 aa)
rpl10e50S ribosomal protein L10e; Belongs to the universal ribosomal protein uL16 family. (160 aa)
MTCT_0987Circadian clock protein KaiC. (472 aa)
rps1030S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rps730S ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (186 aa)
rps1230S ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (141 aa)
rpl30e50S ribosomal protein L30e; Belongs to the eukaryotic ribosomal protein eL30 family. (98 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (353 aa)
top6BDNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (518 aa)
MTCT_0914Conserved hypothetical protein. (188 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (353 aa)
MTCT_0771GTP-binding protein. (343 aa)
MTCT_0737Histone-like transcription factor. (68 aa)
rps17e30S ribosomal protein S17e; Belongs to the eukaryotic ribosomal protein eS17 family. (62 aa)
MTCT_0691Conserved hypothetical protein. (375 aa)
rpl15e50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. (180 aa)
MTCT_0614Conserved hypothetical protein. (232 aa)
rpl37ae50S ribosomal protein L37Ae; Binds to the 23S rRNA. (89 aa)
MTCT_0608Conserved hypothetical protein; Probably involved in the biogenesis of the ribosome. (155 aa)
rpl37e50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (60 aa)
MTCT_0516Conserved hypothetical protein. (233 aa)
MTCT_0001Conserved hypothetical protein. (261 aa)
rpl350S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (337 aa)
rpl450S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (254 aa)
rpl2350S ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rpl250S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (241 aa)
rps19p30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rpl2250S ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (153 aa)
rps330S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (263 aa)
rpl2950S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (64 aa)
MTCT_001230S ribosomal protein S17P; Belongs to the universal ribosomal protein uS17 family. (81 aa)
rpl1450S ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rpl2450S ribosomal protein L24P; Located at the polypeptide exit tunnel on the outside of the subunit. (95 aa)
rps4e30S ribosomal protein S4e; Belongs to the eukaryotic ribosomal protein eS4 family. (242 aa)
rpl550S ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (168 aa)
rps1430S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (47 aa)
rps830S ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (127 aa)
rpl650S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
MTCT_002050S ribosomal protein L32e. (108 aa)
rpl19e50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa)
rpl1850S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (192 aa)
rps530S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (214 aa)
rpl3050S ribosomal protein L30P. (152 aa)
rpl1550S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpl34e50S ribosomal protein L34e; Belongs to the eukaryotic ribosomal protein eL34 family. (88 aa)
rpl14e50S ribosomal protein L14e; Belongs to the eukaryotic ribosomal protein eL14 family. (75 aa)
rps1330S ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa)
rps430S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (171 aa)
rps1130S ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (130 aa)
rpl18e50S ribosomal protein L18e; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa)
rpl1350S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (140 aa)
rps930S ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (133 aa)
rps230S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (198 aa)
rps8e30S ribosomal protein S8e. (127 aa)
MTCT_0171DNA-dependent DNA polymerase. (221 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (470 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (317 aa)
MTCT_0217Histone-like transcription factor. (67 aa)
rpl7ae50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa)
rps28e30S ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family. (68 aa)
rpl24e50S ribosomal protein L24e; Binds to the 23S rRNA. (53 aa)
rps6e30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. (126 aa)
MTCT_0225Conserved hypothetical protein. (117 aa)
rps24e30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family. (100 aa)
rps27ae30S ribosomal protein S27ae; Belongs to the eukaryotic ribosomal protein eS31 family. (51 aa)
MTCT_0379Recombinase. (238 aa)
MTCT_0438Conserved hypothetical protein; Belongs to the UPF0145 family. (110 aa)
mre11Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (418 aa)
rpl40e50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. (48 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (320 aa)
MTCT_0515Conserved hypothetical protein. (224 aa)
Your Current Organism:
Methanothermobacter sp. CaT2
NCBI taxonomy Id: 866790
Other names: M. sp. CaT2
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