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trpB trpB dapL dapL MTCT_0072 MTCT_0072 argJ argJ argB argB MTCT_0151 MTCT_0151 MTCT_0159 MTCT_0159 MTCT_0162 MTCT_0162 MTCT_0216 MTCT_0216 argH argH MTCT_0235 MTCT_0235 MTCT_0355 MTCT_0355 MTCT_0358 MTCT_0358 MTCT_0435 MTCT_0435 cimA cimA metE metE asd asd dapB dapB dapA dapA MTCT_0718 MTCT_0718 argC argC MTCT_0767 MTCT_0767 MTCT_0768 MTCT_0768 MTCT_0814 MTCT_0814 MTCT_0881 MTCT_0881 carB carB carA carA gap gap serS serS MTCT_1112 MTCT_1112 MTCT_1124 MTCT_1124 argG argG dapF dapF lysA lysA argD argD glyA glyA leuC leuC leuD leuD MTCT_1261 MTCT_1261 ilvE ilvE ilvC ilvC MTCT_1311 MTCT_1311 MTCT_1312 MTCT_1312 MTCT_1314 MTCT_1314 ilvD ilvD MTCT_1345 MTCT_1345 MTCT_1375 MTCT_1375 MTCT_1427 MTCT_1427 MTCT_1460 MTCT_1460 MTCT_1485 MTCT_1485 leuC-2 leuC-2 MTCT_1497 MTCT_1497 trpE trpE MTCT_1511 MTCT_1511 trpC trpC trpF trpF trpB-2 trpB-2 trpA trpA trpD trpD MTCT_1520 MTCT_1520 MTCT_1537 MTCT_1537 MTCT_1710 MTCT_1710
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
trpBTryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (428 aa)
dapLPutative L,L-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (410 aa)
MTCT_0072Glutamate synthase (NADPH) alpha subunit; Belongs to the glutamate synthase family. (619 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (399 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa)
MTCT_01513-isopropylmalate dehydrogenase. (329 aa)
MTCT_0159Glutamate synthase (NADPH) alpha subunit; Belongs to the glutamate synthase family. (499 aa)
MTCT_0162Conserved hypothetical protein. (231 aa)
MTCT_0216Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa)
argHArgininosuccinate lyase. (478 aa)
MTCT_0235Acetyltransferase. (202 aa)
MTCT_0355Asparagine synthetase. (469 aa)
MTCT_0358Homoserine dehydrogenase. (337 aa)
MTCT_0435H(2)-dependent methylenetetrahydromethanopterin dehydrogenase. (341 aa)
cimA2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (496 aa)
metEMethionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. (318 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
MTCT_0718Aspartate kinase; Belongs to the aspartokinase family. (406 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
MTCT_0767Ferredoxin. (128 aa)
MTCT_0768Conserved hypothetical protein. (514 aa)
MTCT_0814Pyrroline-5-carboxylate reductase. (250 aa)
MTCT_0881Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1059 aa)
carACarbamoyl phosphate synthase small subunit; Belongs to the CarA family. (360 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (337 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily. (513 aa)
MTCT_1112Chorismate mutase. (233 aa)
MTCT_1124Homoserine dehydrogenase. (423 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (289 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (428 aa)
argDN-acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (423 aa)
leuC3-isopropylmalate dehydratase LeuD subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa)
leuD3-isopropylmalate dehydratase LeuC subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa)
MTCT_12613-isopropylmalate dehydrogenase. (326 aa)
ilvEAminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
MTCT_1311Acetolactate synthase regulatory subunit. (165 aa)
MTCT_1312Acetolactate synthase catalytic subunit. (574 aa)
MTCT_1314Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (549 aa)
MTCT_13452-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa)
MTCT_1375H(2)-dependent methylenetetrahydromethanopterin dehydrogenase-related protein. (341 aa)
MTCT_1427Glutamine synthetase. (442 aa)
MTCT_1460Aspartate aminotransferase. (385 aa)
MTCT_1485Phosphoserine phosphatase. (491 aa)
leuC-23-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa)
MTCT_1497Prephenate dehydrogenase. (442 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (472 aa)
MTCT_1511Anthranilate synthase component II. (194 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (272 aa)
trpF5'-phosphoribosyl anthranilate isomerase; Belongs to the TrpF family. (241 aa)
trpB-2Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (392 aa)
trpATryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa)
MTCT_1520Glutamate synthase; Belongs to the glutamate synthase family. (412 aa)
MTCT_1537Putative ferredoxin. (410 aa)
MTCT_1710Translation initiation factor eIF-2B alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (309 aa)
Your Current Organism:
Methanothermobacter sp. CaT2
NCBI taxonomy Id: 866790
Other names: M. sp. CaT2
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