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| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa) |
| | MTCT_0104 | Putative heterodisulfide reductase. (227 aa) |
| | mfnB | Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (236 aa) |
| | MTCT_0116 | Methyl coenzyme M reductase system component. (568 aa) |
| | MTCT_0151 | 3-isopropylmalate dehydrogenase. (329 aa) |
| | MTCT_0154 | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (325 aa) |
| | MTCT_0156 | Glutamine amidotransferase. (305 aa) |
| | MTCT_0157 | Putative glutamate synthase. (229 aa) |
| | MTCT_0158 | Coenzyme F420-reducing hydrogenase beta subunit. (351 aa) |
| | MTCT_0159 | Glutamate synthase (NADPH) alpha subunit; Belongs to the glutamate synthase family. (499 aa) |
| | MTCT_0179 | acetyl-CoA synthetase. (634 aa) |
| | MTCT_0201 | Tungsten formylmethanofuran dehydrogenase. (307 aa) |
| | MTCT_0212 | Conserved hypothetical protein. (194 aa) |
| | MTCT_0346 | Tetrahydromethanopterin formyltransferase. (297 aa) |
| | apgM | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (399 aa) |
| | aroA | Fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (266 aa) |
| | cofC | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (223 aa) |
| | MTCT_0630 | acetyl-CoA synthetase. (559 aa) |
| | mch | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (320 aa) |
| | cofH | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (371 aa) |
| | hacB | 3-isopropylmalate dehydratase; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD ty [...] (182 aa) |
| | MTCT_0748 | Putative hydantoinase/oxoprolinase. (342 aa) |
| | MTCT_0749 | Conserved hypothetical protein. (324 aa) |
| | MTCT_0805 | Demethylmenaquinone methyltransferase. (220 aa) |
| | MTCT_0833 | Molybdenum formylmethanofuran dehydrogenase subunit E. (180 aa) |
| | MTCT_0834 | Molybdenum formylmethanofuran dehydrogenase subunit C. (400 aa) |
| | MTCT_0835 | Molybdenum formylmethanofuran dehydrogenase subunit B. (436 aa) |
| | MTCT_0841 | Tungsten formylmethanofuran dehydrogenase subunit. (282 aa) |
| | ppcA | Conserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (477 aa) |
| | MTCT_0881 | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa) |
| | MTCT_0923 | ABC transporter ATP-binding subunit. (540 aa) |
| | cofD | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa) |
| | cofE | F420-0--gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (252 aa) |
| | mtrA | Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (180 aa) |
| | mfnA | Glutamate decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (385 aa) |
| | MTCT_1011 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (756 aa) |
| | MTCT_1022 | Methyl coenzyme M reductase II alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa) |
| | MTCT_1023 | Methyl coenzyme M reductase II gamma subunit. (265 aa) |
| | MTCT_1024 | Methyl coenzyme M reductase operon protein D. (161 aa) |
| | MTCT_1025 | Methyl coenzyme M reductase II beta subunit. (443 aa) |
| | MTCT_1027 | Methyl viologen-reducing hydrogenase alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (472 aa) |
| | MTCT_1028 | Methyl viologen-reducing hydrogenase gamma subunit. (308 aa) |
| | MTCT_1029 | Methyl viologen-reducing hydrogenase delta subunit. (141 aa) |
| | MTCT_1031 | Methyl viologen-reducing hydrogenase delta subunit. (136 aa) |
| | MTCT_1032 | Formate dehydrogenase beta subunit. (380 aa) |
| | MTCT_1033 | Formate dehydrogenase alpha subunit. (343 aa) |
| | hmd | H(2)-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (344 aa) |
| | mtrH | Tetrahydromethanopterin S-methyltransferase subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (310 aa) |
| | mtrG | Tetrahydromethanopterin S-methyltransferase subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (86 aa) |
| | mtrF | Tetrahydromethanopterin S-methyltransferase subunit F; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (68 aa) |
| | mtrA-2 | Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (238 aa) |
| | mtrB | Tetrahydromethanopterin S-methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (100 aa) |
| | mtrC | Tetrahydromethanopterin S-methyltransferase subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (267 aa) |
| | mtrD | Tetrahydromethanopterin S-methyltransferase subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (233 aa) |
| | mtrE | Tetrahydromethanopterin S-methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (295 aa) |
| | MTCT_1058 | Methyl coenzyme M reductase I alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa) |
| | MTCT_1059 | Methyl coenzyme M reductase I gamma subunit. (249 aa) |
| | MTCT_1060 | Methyl coenzyme M reductase I C protein. (182 aa) |
| | MTCT_1061 | Methyl coenzyme M reductase I D protein. (145 aa) |
| | MTCT_1062 | Methyl coenzyme M reductase I beta subunit. (398 aa) |
| | comB | 2-phosphosulfolactate phosphatase. (224 aa) |
| | cofG | FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (359 aa) |
| | MTCT_1098 | Malate dehydrogenase. (341 aa) |
| | MTCT_1099 | Phosphonopyruvate decarboxylase. (153 aa) |
| | MTCT_1100 | Phosphonopyruvate decarboxylase. (184 aa) |
| | ftr | Tetrahydromethanopterin formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa) |
| | MTCT_1177 | Coenzyme F420-reducing hydrogenase beta subunit. (281 aa) |
| | MTCT_1178 | Coenzyme F420-reducing hydrogenase gamma subunit. (263 aa) |
| | MTCT_1179 | Coenzyme F420-reducing hydrogenase delta subunit. (150 aa) |
| | MTCT_1180 | Coenzyme F420-reducing hydrogenase alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (385 aa) |
| | MTCT_1219 | Formylmethanofuran dehydrogenase. (171 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (423 aa) |
| | MTCT_1255 | Heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (659 aa) |
| | mtd | F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa) |
| | fae-hps | Formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (406 aa) |
| | MTCT_1411 | Sugar phosphate isomerase. (274 aa) |
| | MTCT_1417 | Formate dehydrogenase alpha subunit. (884 aa) |
| | MTCT_1418 | Tungsten formylmethanofuran dehydrogenase subunit H. (126 aa) |
| | MTCT_1419 | Tungsten formylmethanofuran dehydrogenase subunit F. (349 aa) |
| | MTCT_1420 | Tungsten formylmethanofuran dehydrogenase subunit G. (82 aa) |
| | MTCT_1421 | Tungsten formylmethanofuran dehydrogenase subunit D. (130 aa) |
| | MTCT_1422 | Tungsten formylmethanofuran dehydrogenase subunit A. (569 aa) |
| | MTCT_1423 | Tungsten formylmethanofuran dehydrogenase subunit C. (270 aa) |
| | MTCT_1424 | Tungsten formylmethanofuran dehydrogenase subunit B. (432 aa) |
| | MTCT_1438 | Formate dehydrogenase beta subunit. (394 aa) |
| | MTCT_1439 | Formate dehydrogenase alpha subunit. (663 aa) |
| | apgM-2 | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (409 aa) |
| | MTCT_1462 | acetyl-CoA synthetase. (653 aa) |
| | MTCT_1485 | Phosphoserine phosphatase. (491 aa) |
| | MTCT_1489 | Trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | MTCT_1520 | Glutamate synthase; Belongs to the glutamate synthase family. (412 aa) |
| | MTCT_1527 | (2R)-phospho-3-sulfolactate synthase. (258 aa) |
| | fbp | Fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | MTCT_1550 | Delta 1-pyrroline-5-carboxylate synthetase. (216 aa) |
| | cdhA | acetyl-CoA decarbonylase/synthase complex alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (777 aa) |
| | cdhB | acetyl-CoA decarbonylase/synthase complex epsilon subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family. (170 aa) |
| | cdhC | acetyl-CoA decarbonylase/synthase complex beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (460 aa) |
| | cdhD | acetyl-CoA decarbonylase/synthase complex delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (387 aa) |
| | cdhE | acetyl-CoA decarbonylase/synthase complex gamma subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (458 aa) |
| | MTCT_1586 | Formate hydrogenlyase iron-sulfur subunit. (143 aa) |
| | MTCT_1587 | Formate hydrogenlyase iron-sulfur subunit. (165 aa) |
| | MTCT_1588 | Pyruvate ferredoxin oxidoreductase beta subunit. (288 aa) |
| | MTCT_1589 | Pyruvate ferredoxin oxidoreductase alpha subunit. (383 aa) |
| | MTCT_1590 | Truncated indolepyruvate ferredoxin oxidoreductase. (81 aa) |
| | MTCT_1591 | Truncated indolepyruvate ferredoxin oxidoreductase. (177 aa) |
| | mer | Methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa) |
| | MTCT_1716 | Heterodisulfide reductase subunit C. (317 aa) |
| | MTCT_1717 | Heterodisulfide reductase subunit B. (302 aa) |
