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| | adkA | Adenylate kinase; Belongs to the archaeal adenylate kinase family. (185 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (305 aa) |
| | MTCT_0046 | Conserved hypothetical protein; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (264 aa) |
| | fni | Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (348 aa) |
| | MTCT_0049 | Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (325 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (550 aa) |
| | dapL | Putative L,L-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (410 aa) |
| | MTCT_0099 | Riboflavin synthase. (153 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa) |
| | ubiX | Phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | MTCT_0132 | uroporphyrinogen-III synthase. (266 aa) |
| | MTCT_0133 | uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. (238 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (216 aa) |
| | MTCT_0135 | Phosphoribosylformylglycinamidine synthase subunit PurS. (81 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (248 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (399 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | MTCT_0151 | 3-isopropylmalate dehydrogenase. (329 aa) |
| | MTCT_0154 | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (325 aa) |
| | MTCT_0179 | acetyl-CoA synthetase. (634 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase. (420 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (259 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (112 aa) |
| | MTCT_0216 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (150 aa) |
| | argH | Argininosuccinate lyase. (478 aa) |
| | MTCT_0245 | Putative NAD(P)H oxidoreductase. (196 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (321 aa) |
| | MTCT_0318 | Putative dTDP-glucose 4,6-dehydratase. (313 aa) |
| | MTCT_0355 | Asparagine synthetase. (469 aa) |
| | MTCT_0358 | Homoserine dehydrogenase. (337 aa) |
| | apgM | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (399 aa) |
| | MTCT_0390 | Magnesium chelatase subunit. (591 aa) |
| | MTCT_0461 | 2-oxoacid:ferredoxin oxidoreductase alpha subunit. (555 aa) |
| | MTCT_0462 | 2-oxoacid ferredoxin oxidoreductase beta subunit. (288 aa) |
| | MTCT_0483 | Magnesium chelatase subunit. (667 aa) |
| | MTCT_0489 | 3-hydroxy-3-methylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family. (397 aa) |
| | sucD | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (221 aa) |
| | aroA | Fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (266 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (374 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa) |
| | MTCT_0562 | UTP-glucose-1-phosphate uridylyltransferase. (285 aa) |
| | nifH | Putative nitrogenase reductase; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (265 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (468 aa) |
| | MTCT_0597 | Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. (227 aa) |
| | MTCT_0630 | acetyl-CoA synthetase. (559 aa) |
| | MTCT_0665 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (322 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (367 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (419 aa) |
| | metE | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. (318 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (285 aa) |
| | MTCT_0708 | Conserved hypothetical protein; Belongs to the thiolase-like superfamily. UPF0219 family. (346 aa) |
| | MTCT_0709 | acetyl-CoA acetyltransferase. (383 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | MTCT_0718 | Aspartate kinase; Belongs to the aspartokinase family. (406 aa) |
| | MTCT_0720 | Chorismate mutase. (98 aa) |
| | aroK | Putative shikimate kinase. (286 aa) |
| | hacB | 3-isopropylmalate dehydratase; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD ty [...] (182 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (246 aa) |
| | ribL | Glycerol-3-phosphate cytidyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (151 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | MTCT_0789 | Inositol-1 monophosphatase/fructose-1,6-bisphosphatase. (280 aa) |
| | MTCT_0791 | Putative UDP-N-acetylmuramyl tripeptide synthetase. (437 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (289 aa) |
| | MTCT_0814 | Pyrroline-5-carboxylate reductase. (250 aa) |
| | MTCT_0874 | Fumarate hydratase. (280 aa) |
| | MTCT_0881 | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase. (337 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (399 aa) |
| | MTCT_0921 | Conserved hypothetical protein. (205 aa) |
| | purO | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (202 aa) |
| | asd-2 | Phosphatidylserine decarboxylase; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily. (224 aa) |
| | MTCT_0940 | Ferredoxin. (67 aa) |
| | MTCT_0941 | 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (376 aa) |
| | MTCT_0942 | 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (286 aa) |
| | MTCT_0943 | 2-oxoglutarate ferredoxin oxidoreductase gamma subunit. (186 aa) |
| | sucC | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (366 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (406 aa) |
| | MTCT_0973 | Phosphoglycolate phosphatase; Catalyzes the dephosphorylation of 2-phosphoglycolate. (221 aa) |
| | MTCT_0999 | Myo-inositol-1-phosphate synthase. (365 aa) |
| | MTCT_1009 | Fumarate hydratase. (165 aa) |
| | mfnA | Glutamate decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (385 aa) |
| | MTCT_1011 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (756 aa) |
| | purP | 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranosyl 5'-monophosphate--formate ligase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (363 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase. (338 aa) |
| | MTCT_1112 | Chorismate mutase. (233 aa) |
| | MTCT_1124 | Homoserine dehydrogenase. (423 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase. (96 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (289 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (428 aa) |
| | argD | N-acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (278 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (714 aa) |
| | mat | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (401 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (423 aa) |
| | leuC | 3-isopropylmalate dehydratase LeuD subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa) |
| | leuD | 3-isopropylmalate dehydratase LeuC subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | MTCT_1261 | 3-isopropylmalate dehydrogenase. (326 aa) |
| | ribH | Riboflavin synthase beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (139 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (334 aa) |
| | cbiX | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (128 aa) |
| | ilvE | Aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | surE | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa) |
| | MTCT_1311 | Acetolactate synthase regulatory subunit. (165 aa) |
| | MTCT_1312 | Acetolactate synthase catalytic subunit. (574 aa) |
| | purD | Glycinamide ribonucleotide synthetase; Belongs to the GARS family. (437 aa) |
| | MTCT_1314 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (549 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (187 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (428 aa) |
| | MTCT_1345 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (224 aa) |
| | MTCT_1367 | Conserved hypothetical protein. (231 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | MTCT_1386 | Conserved hypothetical protein. (359 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa) |
| | MTCT_1402 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (449 aa) |
| | MTCT_1443 | Phosphomannomutase; Belongs to the phosphohexose mutase family. (455 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (366 aa) |
| | MTCT_1448 | Glucose-1-phosphate thymidylyltransferase. (423 aa) |
| | apgM-2 | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (409 aa) |
| | MTCT_1461 | Thiamine pyrophosphate; Belongs to the TPP enzyme family. (522 aa) |
| | MTCT_1462 | acetyl-CoA synthetase. (653 aa) |
| | MTCT_1478 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (171 aa) |
| | MTCT_1485 | Phosphoserine phosphatase. (491 aa) |
| | MTCT_1489 | Trans-homoaconitate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | MTCT_1491 | Conserved hypothetical protein. (179 aa) |
| | MTCT_1497 | Prephenate dehydrogenase. (442 aa) |
| | MTCT_1504 | Dihydrolipoamide dehydrogenase. (427 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (472 aa) |
| | MTCT_1511 | Anthranilate synthase component II. (194 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (272 aa) |
| | trpF | 5'-phosphoribosyl anthranilate isomerase; Belongs to the TrpF family. (241 aa) |
| | trpB-2 | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (392 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa) |
| | MTCT_1517 | Adenylate kinase. (189 aa) |
| | fbp | Fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | MTCT_1546 | Aspartate aminotransferase. (385 aa) |
| | MTCT_1585 | Fumarate hydratase. (281 aa) |
| | MTCT_1588 | Pyruvate ferredoxin oxidoreductase beta subunit. (288 aa) |
| | MTCT_1589 | Pyruvate ferredoxin oxidoreductase alpha subunit. (383 aa) |
| | MTCT_1590 | Truncated indolepyruvate ferredoxin oxidoreductase. (81 aa) |
| | MTCT_1591 | Truncated indolepyruvate ferredoxin oxidoreductase. (177 aa) |
| | MTCT_1603 | Alpha,alpha-trehalose-phosphate synthase. (496 aa) |
| | MTCT_1605 | Mannose-1-phosphate guanyltransferase. (378 aa) |
| | MTCT_1606 | Putative trehalose-6-phosphate phophatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (264 aa) |
| | MTCT_1628 | Conserved hypothetical protein. (462 aa) |
| | MTCT_1631 | dTDP-glucose 4,6-dehydratase. (336 aa) |
| | MTCT_1632 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | MTCT_1633 | Glucose-1-phosphate thymidylyltransferase. (292 aa) |
| | MTCT_1634 | dTDP-4-dehydrorhamnose reductase. (277 aa) |
| | MTCT_1644 | Conserved hypothetical protein. (313 aa) |
| | MTCT_1648 | Truncated phytoene synthase. (186 aa) |
| | MTCT_1660 | Homoserine O-acetyltransferase. (320 aa) |
| | MTCT_1725 | Aspartate aminotransferase. (372 aa) |
| | MTCT_1742 | Fumarate hydratase. (198 aa) |
