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| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa) |
| | MTCT_0104 | Putative heterodisulfide reductase. (227 aa) |
| | MTCT_0154 | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (325 aa) |
| | MTCT_0179 | acetyl-CoA synthetase. (634 aa) |
| | MTCT_0201 | Tungsten formylmethanofuran dehydrogenase. (307 aa) |
| | MTCT_0212 | Conserved hypothetical protein. (194 aa) |
| | MTCT_0346 | Tetrahydromethanopterin formyltransferase. (297 aa) |
| | apgM | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (399 aa) |
| | MTCT_0461 | 2-oxoacid:ferredoxin oxidoreductase alpha subunit. (555 aa) |
| | MTCT_0462 | 2-oxoacid ferredoxin oxidoreductase beta subunit. (288 aa) |
| | sucD | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa) |
| | aroA | Fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (266 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa) |
| | MTCT_0630 | acetyl-CoA synthetase. (559 aa) |
| | mch | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (320 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (285 aa) |
| | MTCT_0709 | acetyl-CoA acetyltransferase. (383 aa) |
| | MTCT_0805 | Demethylmenaquinone methyltransferase. (220 aa) |
| | MTCT_0833 | Molybdenum formylmethanofuran dehydrogenase subunit E. (180 aa) |
| | MTCT_0834 | Molybdenum formylmethanofuran dehydrogenase subunit C. (400 aa) |
| | MTCT_0835 | Molybdenum formylmethanofuran dehydrogenase subunit B. (436 aa) |
| | MTCT_0841 | Tungsten formylmethanofuran dehydrogenase subunit. (282 aa) |
| | ppcA | Conserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (477 aa) |
| | MTCT_0874 | Fumarate hydratase. (280 aa) |
| | MTCT_0881 | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase. (337 aa) |
| | MTCT_0940 | Ferredoxin. (67 aa) |
| | MTCT_0941 | 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (376 aa) |
| | MTCT_0942 | 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (286 aa) |
| | MTCT_0943 | 2-oxoglutarate ferredoxin oxidoreductase gamma subunit. (186 aa) |
| | sucC | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (366 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (406 aa) |
| | mtrA | Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (180 aa) |
| | MTCT_1001 | Pyruvate carboxylase subunit B. (568 aa) |
| | MTCT_1009 | Fumarate hydratase. (165 aa) |
| | MTCT_1011 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (756 aa) |
| | MTCT_1022 | Methyl coenzyme M reductase II alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (553 aa) |
| | MTCT_1023 | Methyl coenzyme M reductase II gamma subunit. (265 aa) |
| | MTCT_1025 | Methyl coenzyme M reductase II beta subunit. (443 aa) |
| | MTCT_1027 | Methyl viologen-reducing hydrogenase alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (472 aa) |
| | MTCT_1028 | Methyl viologen-reducing hydrogenase gamma subunit. (308 aa) |
| | MTCT_1029 | Methyl viologen-reducing hydrogenase delta subunit. (141 aa) |
| | MTCT_1031 | Methyl viologen-reducing hydrogenase delta subunit. (136 aa) |
| | MTCT_1032 | Formate dehydrogenase beta subunit. (380 aa) |
| | MTCT_1033 | Formate dehydrogenase alpha subunit. (343 aa) |
| | hmd | H(2)-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (344 aa) |
| | mtrH | Tetrahydromethanopterin S-methyltransferase subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (310 aa) |
| | mtrG | Tetrahydromethanopterin S-methyltransferase subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (86 aa) |
| | mtrF | Tetrahydromethanopterin S-methyltransferase subunit F; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (68 aa) |
| | mtrA-2 | Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (238 aa) |
| | mtrB | Tetrahydromethanopterin S-methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (100 aa) |
| | mtrC | Tetrahydromethanopterin S-methyltransferase subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (267 aa) |
| | mtrD | Tetrahydromethanopterin S-methyltransferase subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (233 aa) |
| | mtrE | Tetrahydromethanopterin S-methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (295 aa) |
| | MTCT_1058 | Methyl coenzyme M reductase I alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa) |
| | MTCT_1059 | Methyl coenzyme M reductase I gamma subunit. (249 aa) |
| | MTCT_1062 | Methyl coenzyme M reductase I beta subunit. (398 aa) |
| | ftr | Tetrahydromethanopterin formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa) |
| | MTCT_1219 | Formylmethanofuran dehydrogenase. (171 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (423 aa) |
| | MTCT_1255 | Heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (659 aa) |
| | mtd | F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa) |
| | fae-hps | Formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (406 aa) |
| | MTCT_1366 | Succinate dehydrogenase flavoprotein subunit. (552 aa) |
| | MTCT_1411 | Sugar phosphate isomerase. (274 aa) |
| | MTCT_1417 | Formate dehydrogenase alpha subunit. (884 aa) |
| | MTCT_1418 | Tungsten formylmethanofuran dehydrogenase subunit H. (126 aa) |
| | MTCT_1419 | Tungsten formylmethanofuran dehydrogenase subunit F. (349 aa) |
| | MTCT_1420 | Tungsten formylmethanofuran dehydrogenase subunit G. (82 aa) |
| | MTCT_1421 | Tungsten formylmethanofuran dehydrogenase subunit D. (130 aa) |
| | MTCT_1422 | Tungsten formylmethanofuran dehydrogenase subunit A. (569 aa) |
| | MTCT_1423 | Tungsten formylmethanofuran dehydrogenase subunit C. (270 aa) |
| | MTCT_1424 | Tungsten formylmethanofuran dehydrogenase subunit B. (432 aa) |
| | MTCT_1438 | Formate dehydrogenase beta subunit. (394 aa) |
| | MTCT_1439 | Formate dehydrogenase alpha subunit. (663 aa) |
| | apgM-2 | Cofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (409 aa) |
| | MTCT_1462 | acetyl-CoA synthetase. (653 aa) |
| | MTCT_1485 | Phosphoserine phosphatase. (491 aa) |
| | MTCT_1504 | Dihydrolipoamide dehydrogenase. (427 aa) |
| | fbp | Fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | cdhA | acetyl-CoA decarbonylase/synthase complex alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (777 aa) |
| | cdhB | acetyl-CoA decarbonylase/synthase complex epsilon subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family. (170 aa) |
| | cdhC | acetyl-CoA decarbonylase/synthase complex beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (460 aa) |
| | cdhD | acetyl-CoA decarbonylase/synthase complex delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (387 aa) |
| | cdhE | acetyl-CoA decarbonylase/synthase complex gamma subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (458 aa) |
| | MTCT_1585 | Fumarate hydratase. (281 aa) |
| | MTCT_1586 | Formate hydrogenlyase iron-sulfur subunit. (143 aa) |
| | MTCT_1587 | Formate hydrogenlyase iron-sulfur subunit. (165 aa) |
| | MTCT_1588 | Pyruvate ferredoxin oxidoreductase beta subunit. (288 aa) |
| | MTCT_1589 | Pyruvate ferredoxin oxidoreductase alpha subunit. (383 aa) |
| | MTCT_1590 | Truncated indolepyruvate ferredoxin oxidoreductase. (81 aa) |
| | MTCT_1591 | Truncated indolepyruvate ferredoxin oxidoreductase. (177 aa) |
| | mer | Methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa) |
| | MTCT_1689 | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (489 aa) |
| | MTCT_1716 | Heterodisulfide reductase subunit C. (317 aa) |
| | MTCT_1717 | Heterodisulfide reductase subunit B. (302 aa) |
| | MTCT_1742 | Fumarate hydratase. (198 aa) |
| | MTCT_1749 | Pyruvate carboxylase subunit A. (491 aa) |
