STRINGSTRING
ADY72799.1 ADY72799.1 ADY72904.1 ADY72904.1 ADY72915.1 ADY72915.1 ADY72932.1 ADY72932.1 ADY72977.1 ADY72977.1 ADY73008.1 ADY73008.1 ADY73030.1 ADY73030.1 ADY73031.1 ADY73031.1 ADY73072.1 ADY73072.1 ADY73073.1 ADY73073.1 ADY73103.1 ADY73103.1 ADY73104.1 ADY73104.1 ADY73105.1 ADY73105.1 ADY73147.1 ADY73147.1 ADY73174.1 ADY73174.1 gpmI gpmI mdh mdh eno eno ADY73474.1 ADY73474.1 glyA glyA fbp fbp ADY73707.1 ADY73707.1 ADY73708.1 ADY73708.1 ADY73709.1 ADY73709.1 ADY73710.1 ADY73710.1 ADY73972.1 ADY73972.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADY72799.1Formate dehydrogenase, putative; COGs: COG2864 Cytochrome b subunit of formate dehydrogenase; KEGG: shl:Shal_1410 formate dehydrogenase, putative; SPTR: Putative formate dehydrogenase; PFAM: Cytochrome b(N-terminal)/b6/petB; TIGRFAM: formate dehydrogenase, gamma subunit. (225 aa)
ADY72904.1COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139: IPR006140: IPR002912: IPR006236; KEGG: sul:SYO3AOP1_0259 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT; PRIAM: Phosphoglycerate dehydrogenase; SPTR: Phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase [...] (529 aa)
ADY72915.1Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: cyc:PCC7424_1967 phosphoglycerate mutase; PFAM: Histidine phosphatase superfamily, clade-1; SPTR: Phosphoglycerate mutase; PFAM: Phosphoglycerate mutase family. (217 aa)
ADY72932.1acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (631 aa)
ADY72977.1COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR010210: IPR002915; KEGG: aae:aq_1554 fructose-bisphosphate aldolase; PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; PRIAM: Fructose-bisphosphate aldolase; SPTR: Uncharacterized aldolase aq_1554; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DeoC/LacD family aldolase; TIGRFAM: predicted phospho-2-dehydro-3-deoxyheptonate aldolase. (264 aa)
ADY73008.1KEGG: cla:Cla_0807 cytochrome c family protein; SPTR: Cytochrome c family protein; PFAM: Cytochrome b(N-terminal)/b6/petB. (310 aa)
ADY73030.1Hydrogen dehydrogenase; COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501; KEGG: tye:THEYE_A1365 F420-non-reducing hydrogenase subunit A, selenocysteine-containing; PFAM: Nickel-dependent hydrogenase, large subunit; PRIAM: Hydrogen dehydrogenase; SPTR: F420-non-reducing hydrogenase subunit A, selenocysteine-containing; PFAM: Nickel-dependent hydrogenase. (486 aa)
ADY73031.1NADH ubiquinone oxidoreductase 20 kDa subunit; COGs: COG1941 Coenzyme F420-reducing hydrogenase gamma subunit; InterPro IPR006137; KEGG: tye:THEYE_A1366 F420-non-reducing hydrogenase subunit G; PFAM: NADH:ubiquinone oxidoreductase-like, 20kDa subunit; SPTR: F420-non-reducing hydrogenase subunit G; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit. (316 aa)
ADY73072.1Carbon-monoxide dehydrogenase, catalytic subunit; COGs: COG1151 6Fe-6S prismane cluster-containing protein; InterPro IPR010047: IPR004137; KEGG: tga:TGAM_0824 carbon monoxide dehydrogenase (CooS); PFAM: Prismane; PRIAM: Carbon-monoxide dehydrogenase (acceptor); SPTR: Carbon monoxide dehydrogenase (CooS); TIGRFAM: Carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane/CO dehydrogenase family; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit. (626 aa)
ADY73073.14Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG0437 Fe-S-cluster-containing hydrogenase components 1; KEGG: mpl:Mpal_0841 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S binding domain. (181 aa)
ADY73103.1COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501; KEGG: mvo:Mvol_0587 coenzyme F420 hydrogenase, subunit alpha; PFAM: Nickel-dependent hydrogenase, large subunit; PRIAM: Coenzyme F420 hydrogenase; SPTR: Coenzyme F420 hydrogenase, subunit alpha; PFAM: Nickel-dependent hydrogenase; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha. (390 aa)
ADY73104.1COGs: COG1941 Coenzyme F420-reducing hydrogenase gamma subunit; InterPro IPR006137; KEGG: mif:Metin_0513 hypothetical protein; PFAM: NADH:ubiquinone oxidoreductase-like, 20kDa subunit; PRIAM: Coenzyme F420 hydrogenase; SPTR: Putative uncharacterized protein; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: coenzyme F420 hydrogenase, subunit gamma. (247 aa)
ADY73105.1COGs: COG1035 Coenzyme F420-reducing hydrogenase beta subunit; InterPro IPR007525; KEGG: mvo:Mvol_0590 coenzyme F420 hydrogenase, subunit beta; PFAM: Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal; SPTR: Coenzyme F420 hydrogenase, subunit beta; PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus. (300 aa)
ADY73147.1KEGG: apo:Arcpr_1004 cytochrome b subunit of formate dehydrogenase-like protein; SPTR: Cytochrome b subunit of formate dehydrogenase-like protein; PFAM: Prokaryotic cytochrome b561. (226 aa)
ADY73174.1COGs: COG1142 Fe-S-cluster-containing hydrogenase components 2; KEGG: gur:Gura_2493 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; SPTR: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (149 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (526 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
ADY73474.1Carbon-monoxide dehydrogenase, catalytic subunit; COGs: COG1151 6Fe-6S prismane cluster-containing protein; InterPro IPR010047: IPR004137; KEGG: fpl:Ferp_2369 carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane; PRIAM: Carbon-monoxide dehydrogenase (acceptor); SPTR: Carbon-monoxide dehydrogenase, catalytic subunit; TIGRFAM: Carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane/CO dehydrogenase family; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit. (653 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
fbpFructose-1,6-bisphosphatase class 1; COGs: COG0158 Fructose-1 6-bisphosphatase; HAMAP: Fructose-1,6-bisphosphatase; InterPro IPR000146; KEGG: saf:SULAZ_1502 fructose-1,6-bisphosphatase; PFAM: Fructose-1,6-bisphosphatase; PRIAM: Fructose-bisphosphatase; SPTR: Fructose-1,6-bisphosphatase class 1; PFAM: Fructose-1-6-bisphosphatase. (311 aa)
ADY73707.1COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: dth:DICTH_1986 PorB subunit of pyruvate:flavodoxin oxidoreductase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate synthase; SPTR: PorB subunit of pyruvate:flavodoxin oxidoreductase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (325 aa)
ADY73708.1COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: dtu:Dtur_0262 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; PRIAM: Pyruvate synthase; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: domain. (402 aa)
ADY73709.1COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR011898; KEGG: kol:Kole_0380 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; SPTR: Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (97 aa)
ADY73710.1Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752: IPR011894; KEGG: tye:THEYE_A0907 pyruvate synthase subunit PorC; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; PRIAM: Pyruvate synthase; SPTR: Pyruvate synthase subunit PorC; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2- [...] (188 aa)
ADY73972.1Formate dehydrogenase, alpha subunit; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; Contains Selenocysteine; InterPro IPR006478: IPR006963: IPR006656: IPR006657; KEGG: ant:Arnit_0741 formate dehydrogenase subunit alpha; PFAM: Molybdopterin oxidoreductase; Molybdopterin oxidoreductase, Fe4S4 domain; Molydopterin dinucleotide-binding domain; PRIAM: Nitrate reductase; SPTR: Formate dehydrogenase, alpha subunit; TIGRFAM: Formate dehydrogenase, alpha subunit; manually curated; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase [...] (745 aa)
Your Current Organism:
Desulfurobacterium thermolithotrophum
NCBI taxonomy Id: 868864
Other names: D. thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum BSA, Desulfurobacterium thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum str. DSM 11699, Desulfurobacterium thermolithotrophum strain DSM 11699
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.