node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEB14282.1 | dut | Tresu_1375 | Tresu_2085 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: tde:TDE2193 deoxycytidylate deaminase, putative; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: dCMP deaminase; IMG reference gene:2504608316; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.941 |
AEB14282.1 | thyX | Tresu_1375 | Tresu_2321 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: tde:TDE2193 deoxycytidylate deaminase, putative; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: dCMP deaminase; IMG reference gene:2504608316; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.911 |
AEB14282.1 | tmk | Tresu_1375 | Tresu_1840 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: tde:TDE2193 deoxycytidylate deaminase, putative; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: dCMP deaminase; IMG reference gene:2504608316; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.926 |
AEB15223.1 | coaD | Tresu_2360 | Tresu_1212 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.942 |
AEB15223.1 | coaX | Tresu_2360 | Tresu_1135 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.934 |
AEB15223.1 | dut | Tresu_2360 | Tresu_2085 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.932 |
coaD | AEB15223.1 | Tresu_1212 | Tresu_2360 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.942 |
coaD | coaX | Tresu_1212 | Tresu_1135 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.943 |
coaX | AEB15223.1 | Tresu_1135 | Tresu_2360 | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.934 |
coaX | coaD | Tresu_1135 | Tresu_1212 | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.943 |
coaX | tmk | Tresu_1135 | Tresu_1840 | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.580 |
dut | AEB14282.1 | Tresu_2085 | Tresu_1375 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: tde:TDE2193 deoxycytidylate deaminase, putative; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: dCMP deaminase; IMG reference gene:2504608316; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | 0.941 |
dut | AEB15223.1 | Tresu_2085 | Tresu_2360 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.932 |
dut | thyX | Tresu_2085 | Tresu_2321 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.932 |
dut | tmk | Tresu_2085 | Tresu_1840 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.945 |
thyX | AEB14282.1 | Tresu_2321 | Tresu_1375 | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: tde:TDE2193 deoxycytidylate deaminase, putative; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: dCMP deaminase; IMG reference gene:2504608316; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | 0.911 |
thyX | dut | Tresu_2321 | Tresu_2085 | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.932 |
thyX | tmk | Tresu_2321 | Tresu_1840 | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.926 |
tmk | AEB14282.1 | Tresu_1840 | Tresu_1375 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: tde:TDE2193 deoxycytidylate deaminase, putative; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: dCMP deaminase; IMG reference gene:2504608316; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | 0.926 |
tmk | coaX | Tresu_1840 | Tresu_1135 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.580 |