133 items (Theileria orientalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TOT_040000987	GN3L_Grn1 domain-containing protein. (66 aa)
	TOT_040000766	Pumilio RNA-binding region repeat containing protein. (539 aa)
	TOT_010000217	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
	TOT_010001212	ATP-dependent RNA helicase. (578 aa)
	TOT_010000033	U3 small nucleolar ribonucleoprotein. (292 aa)
	TOT_010000013	Uncharacterized protein. (732 aa)
	TOT_010001225	Uncharacterized protein. (663 aa)
	TOT_010000215	WD_REPEATS_REGION domain-containing protein. (479 aa)
	TOT_010000170	Uncharacterized protein. (267 aa)
	TOT_040000887	CBF domain-containing protein. (551 aa)
	TOT_040000780	WD_REPEATS_REGION domain-containing protein. (334 aa)
	TOT_040000740	G domain-containing protein. (724 aa)
	TOT_040000720	50S ribosomal protein L7Ae. (179 aa)
	TOT_010000225	Utp21 domain-containing protein. (924 aa)
	TOT_010000220	Pre-rRNA processing protein. (371 aa)
	TOT_010000168	Utp12 domain-containing protein. (342 aa)
	TOT_010000147	Uncharacterized protein. (726 aa)
	TOT_040000450	CLP1_P domain-containing protein. (674 aa)
	TOT_040000420	ZZ-type domain-containing protein. (529 aa)
	TOT_040000328	RNase_PH domain-containing protein. (404 aa)
	TOT_040000926	Uncharacterized protein. (546 aa)
	TOT_040000100	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (813 aa)
	TOT_040000050	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (129 aa)
	TOT_030000863	Putative RPC10 subunit of RNA polymerases I, II, and III. (364 aa)
	TOT_030000857	Methyltransferase. (279 aa)
	TOT_030000452	RNA processing factor. (180 aa)
	TOT_030000270	Ribosome biogenesis protein. (284 aa)
	TOT_030000250	WD_REPEATS_REGION domain-containing protein. (528 aa)
	TOT_030000230	BOP1NT domain-containing protein. (807 aa)
	TOT_030000061	Tgf beta-inducible nuclear protein 1. (259 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (824 aa)
	TOT_020000799	DNA-directed RNA polymerases I and III subunit. (305 aa)
	TOT_020000730	WD_REPEATS_REGION domain-containing protein. (315 aa)
	TOT_020000700	Uncharacterized protein. (635 aa)
	TOT_020001080	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (555 aa)
	TOT_020000646	Transducin-like G-protein beta. (998 aa)
	TOT_020000485	RNA helicase. (726 aa)
	TOT_020001045	WD_REPEATS_REGION domain-containing protein. (892 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (249 aa)
	TOT_020000231	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (950 aa)
	TOT_020000219	DNA-directed RNA polymerase subunit RPB10. (79 aa)
	TOT_010001153	Uncharacterized protein. (613 aa)
	TOT_010001118	Uncharacterized protein. (197 aa)
	TOT_010000994	3' exonuclease, exosome component. (258 aa)
	TOT_010000895	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (277 aa)
	TOT_010001307	Exosome ribonuclease PH. (130 aa)
	TOT_010000808	TFIIS-type domain-containing protein. (253 aa)
	TOT_010000782	Brix domain-containing protein. (312 aa)
	TOT_010000728	Uncharacterized protein. (235 aa)
	TOT_010000718	Eukaryotic translation initiation factor; Belongs to the DEAD box helicase family. (413 aa)
	TOT_040000959	60S ribosomal subunit biogenesis protein. (77 aa)
	TOT_040000391	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	TOT_040000081	Uncharacterized protein. (227 aa)
	TOT_030000737	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (552 aa)
	TOT_030000622	60S ribosomal protein L24. (184 aa)
	TOT_030000593	Uncharacterized protein. (699 aa)
	TOT_030000453	RNA processing factor. (153 aa)
	TOT_030000062	DUF1604 domain-containing protein. (528 aa)
	TOT_020000750	Fcf2 domain-containing protein. (238 aa)
	TOT_020000736	Uncharacterized protein. (1071 aa)
	TOT_020000613	Uncharacterized protein. (1924 aa)
	TOT_020000535	Nucleolar protein Nop5. (487 aa)
	TOT_020000292	Topoisomerase-related nucleotidyltransferase. (520 aa)
	TOT_020000191	DNA-directed RNA polymerase 2 subunit; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (166 aa)
	TOT_010001124	Ribonuclease P subunit. (237 aa)
	TOT_010001336	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (232 aa)
	TOT_010000798	DNA repair protein. (291 aa)
	TOT_010000754	G-patch domain-containing protein. (141 aa)
	TOT_010000729	Uncharacterized protein. (485 aa)
	TOT_010001288	Ribonucleolar protein. (575 aa)
	TOT_010000675	Nucleolar protein. (57 aa)
	TOT_010000347	Uncharacterized protein. (638 aa)
	TOT_040000651	WD_REPEATS_REGION domain-containing protein. (528 aa)
	TOT_040000527	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1204 aa)
	TOT_040000443	RNA polymerases I and III subunit. (981 aa)
	TOT_040000154	DEAD-box family helicase; Belongs to the DEAD box helicase family. (567 aa)
	TOT_040000134	Fibrillarin. (226 aa)
	TOT_040000119	Microtubule-associated protein. (434 aa)
	TOT_030000540	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (264 aa)
	TOT_030000485	Uncharacterized protein. (2006 aa)
	TOT_030000425	U3 small nucleolar ribonucleoprotein/40S ribosomal protein S4-like. (183 aa)
	TOT_030000168	Protein MAK16 homolog; Belongs to the MAK16 family. (222 aa)
	TOT_030000089	Uncharacterized protein. (327 aa)
	TOT_030000084	Uncharacterized protein. (808 aa)
	TOT_020000936	Uncharacterized protein. (285 aa)
	TOT_010000977	Nucleolar phosphoprotein. (194 aa)
	TOT_010001308	Exosome complex exonuclease. (255 aa)
	TOT_010000776	RNA helicase. (650 aa)
	TOT_010000643	DEAD-box family helicase. (1400 aa)
	TOT_040000618	WD_REPEATS_REGION domain-containing protein. (445 aa)
	TOT_040000454	RNA polymerase common subunit. (153 aa)
	TOT_040000029	DNA-directed RNA polymerase. (205 aa)
	TOT_030000466	3'-5' exonuclease domain-containing protein. (820 aa)
	TOT_030000421	DEAD-box family RNA helicase. (571 aa)
	TOT_020000912	G domain-containing protein. (597 aa)
	TOT_020000714	WD_REPEATS_REGION domain-containing protein. (462 aa)
	TOT_020000675	SHS2_Rpb7-N domain-containing protein. (228 aa)
	TOT_020001072	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (396 aa)
	TOT_020000420	RNA helicase. (693 aa)
	TOT_020000315	ATP-dependent RNA helicase. (553 aa)
	TOT_020000209	WD_REPEATS_REGION domain-containing protein. (307 aa)
	TOT_010000973	WD_REPEATS_REGION domain-containing protein. (489 aa)
	TOT_010000943	Sm domain-containing protein. (79 aa)
	TOT_010001304	Pre-rRNA-processing protein PNO1. (233 aa)
	TOT_010000698	Disrupter of silencing protein. (585 aa)
	TOT_010000526	Uncharacterized protein. (325 aa)
	TOT_010000511	Uncharacterized protein. (180 aa)
	TOT_010000325	WD_REPEATS_REGION domain-containing protein. (940 aa)
	TOT_040000670	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (463 aa)
	TOT_040000660	Uncharacterized protein. (377 aa)
	TOT_040000541	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (177 aa)
	TOT_040000506	Uncharacterized protein. (760 aa)
	TOT_040000370	RING-type domain-containing protein. (451 aa)
	TOT_040000077	Signal recognition particle subunit. (594 aa)
	TOT_030000860	Uncharacterized protein. (738 aa)
	TOT_030000834	S1 domain-containing protein. (707 aa)
	TOT_030000804	Bms1-type G domain-containing protein. (952 aa)
	TOT_030000658	ATP-dependent RNA helicase. (958 aa)
	TOT_030000633	Uncharacterized protein; Belongs to the DEAD box helicase family. (511 aa)
	TOT_030000379	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (639 aa)
	TOT_030000267	Uncharacterized protein. (88 aa)
	TOT_030000177	SRP40_C domain-containing protein. (192 aa)
	TOT_020000801	Uncharacterized protein. (378 aa)
	TOT_020000751	Uncharacterized protein. (946 aa)
	TOT_020000600	PINc domain-containing protein. (340 aa)
	TOT_020001050	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (389 aa)
	TOT_020000228	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (593 aa)
	TOT_010000862	Uncharacterized protein. (137 aa)
	TOT_010000847	Uncharacterized protein. (671 aa)
	TOT_010001294	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1960 aa)
	TOT_010000358	Exosome complex exonuclease rrp41. (254 aa)
	TOT_010000318	C2H2-type domain-containing protein. (429 aa)
	TOT_010000284	Uncharacterized protein. (314 aa)

Your Current Organism:

Theileria orientalis

NCBI taxonomy Id: 869250
Other names: T. orientalis strain Shintoku, Theileria orientalis strain Shintoku

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF6	TOT_010000318	J4DP41	J4C2K5	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	C2H2-type domain-containing protein.	0.996
EIF6	TOT_010000511	J4DP41	J4C7H5	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.435
EIF6	TOT_010000526	J4DP41	J4C7H8	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.950
EIF6	TOT_010000718	J4DP41	J4DNN3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Eukaryotic translation initiation factor; Belongs to the DEAD box helicase family.	0.674
EIF6	TOT_010000776	J4DP41	J4CCF8	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	RNA helicase.	0.483
EIF6	TOT_010000782	J4DP41	J4DNP6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Brix domain-containing protein.	0.936
EIF6	TOT_010000847	J4DP41	J4C2W3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.935
EIF6	TOT_010000895	J4DP41	J4DNR9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.561
EIF6	TOT_010000977	J4DP41	J4CCJ9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Nucleolar phosphoprotein.	0.974
EIF6	TOT_010001212	J4DP41	J7MEN6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	ATP-dependent RNA helicase.	0.477
EIF6	TOT_010001336	J4DP41	J4D6D7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.985
EIF6	TOT_020000209	J4DP41	J4C803	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	WD_REPEATS_REGION domain-containing protein.	0.713
EIF6	TOT_020000228	J4DP41	J4C377	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.899
EIF6	TOT_020000315	J4DP41	J4C825	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	ATP-dependent RNA helicase.	0.445
EIF6	TOT_020000420	J4DP41	J4C847	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	RNA helicase.	0.893
EIF6	TOT_020000485	J4DP41	J4DP76	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	RNA helicase.	0.518
EIF6	TOT_020000535	J4DP41	J4D7N2	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Nucleolar protein Nop5.	0.668
EIF6	TOT_020000700	J4DP41	J4DPC1	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.621
EIF6	TOT_020000912	J4DP41	J4C8E7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	G domain-containing protein.	0.899
EIF6	TOT_020001050	J4DP41	J4C399	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.	0.662