(44 nodes) Mixed, incl. Clathrin binding, and ERMES complex network (Metschnikowia bicuspidata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A1A0H1T1	EF-hand. (150 aa)
	A0A1A0H237	Uncharacterized protein. (665 aa)
	A0A1A0H4Y7	Kinase-like protein. (720 aa)
	A0A1A0H5B3	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (686 aa)
	A0A1A0H5M0	Mitochondrial carrier. (535 aa)
	A0A1A0H5S4	Clathrin adaptor, mu subunit; Belongs to the adaptor complexes medium subunit family. (518 aa)
	A0A1A0H5X4	ARM repeat-containing protein. (760 aa)
	A0A1A0H5Y8	ANTH-domain-containing protein. (637 aa)
	MMM1	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (338 aa)
	A0A1A0H6E3	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (667 aa)
	A0A1A0H6Z3	P-loop containing nucleoside triphosphate hydrolase protein. (1425 aa)
	A0A1A0H7L3	AP-1 complex subunit gamma. (816 aa)
	A0A1A0H7Q8	Clathrin adaptor, mu subunit; Belongs to the adaptor complexes medium subunit family. (443 aa)
	A0A1A0H801	Uncharacterized protein. (1376 aa)
	A0A1A0H8J1	ENTH domain-containing protein. (181 aa)
	A0A1A0H8P8	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1666 aa)
	A0A1A0H9H1	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (881 aa)
	A0A1A0HA89	ENTH-domain-containing protein. (480 aa)
	A0A1A0HAD1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
	MDM12	Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...] (352 aa)
	A0A1A0HBN4	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (974 aa)
	A0A1A0HCQ5	MHD domain-containing protein. (851 aa)
	A0A1A0HDJ0	Mitochondrial fission 1 protein; Has a role in mitochondrial fission. (151 aa)
	A0A1A0HDZ0	Tricalbin. (1450 aa)
	A0A1A0HE83	ANTH-domain-containing protein. (1027 aa)
	MDM10	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...] (450 aa)
	A0A1A0HGD5	Clathrin adaptor, mu subunit; Belongs to the adaptor complexes medium subunit family. (443 aa)
	A0A1A0HGR7	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (872 aa)
	A0A1A0HH93	Uncharacterized protein. (1397 aa)
	A0A1A0HHN4	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (735 aa)
	A0A1A0HHV0	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (153 aa)
	A0A1A0HHW6	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (755 aa)
	A0A1A0HI45	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	A0A1A0HI56	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (816 aa)
	A0A1A0HIC3	Kinase-like protein. (701 aa)
	A0A1A0HIF1	TRP-domain-containing protein. (242 aa)
	A0A1A0HJA8	Uncharacterized protein. (382 aa)
	A0A1A0HJN3	TBC-domain-containing protein. (924 aa)
	A0A1A0HJS8	Zn(2)-C6 fungal-type domain-containing protein. (829 aa)
	A0A1A0HJW2	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1043 aa)
	A0A1A0HJY6	Uncharacterized protein. (716 aa)
	A0A1A0HK14	Clathrin adaptor, mu subunit; Belongs to the adaptor complexes medium subunit family. (627 aa)
	A0A1A0HK35	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (559 aa)

Your Current Organism:

Metschnikowia bicuspidata

NCBI taxonomy Id: 869754
Other names: M. bicuspidata var. bicuspidata NRRL YB-4993, Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1A0H1T1	A0A1A0H237	A0A1A0H1T1	A0A1A0H237	EF-hand.	Uncharacterized protein.	0.477
A0A1A0H1T1	A0A1A0H4Y7	A0A1A0H1T1	A0A1A0H4Y7	EF-hand.	Kinase-like protein.	0.677
A0A1A0H1T1	A0A1A0H5B3	A0A1A0H1T1	A0A1A0H5B3	EF-hand.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.729
A0A1A0H1T1	A0A1A0H5Y8	A0A1A0H1T1	A0A1A0H5Y8	EF-hand.	ANTH-domain-containing protein.	0.746
A0A1A0H1T1	A0A1A0H6E3	A0A1A0H1T1	A0A1A0H6E3	EF-hand.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.458
A0A1A0H1T1	A0A1A0H6Z3	A0A1A0H1T1	A0A1A0H6Z3	EF-hand.	P-loop containing nucleoside triphosphate hydrolase protein.	0.641
A0A1A0H1T1	A0A1A0H7L3	A0A1A0H1T1	A0A1A0H7L3	EF-hand.	AP-1 complex subunit gamma.	0.715
A0A1A0H1T1	A0A1A0H7Q8	A0A1A0H1T1	A0A1A0H7Q8	EF-hand.	Clathrin adaptor, mu subunit; Belongs to the adaptor complexes medium subunit family.	0.738
A0A1A0H1T1	A0A1A0H8J1	A0A1A0H1T1	A0A1A0H8J1	EF-hand.	ENTH domain-containing protein.	0.753
A0A1A0H1T1	A0A1A0H8P8	A0A1A0H1T1	A0A1A0H8P8	EF-hand.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.773
A0A1A0H1T1	A0A1A0HA89	A0A1A0H1T1	A0A1A0HA89	EF-hand.	ENTH-domain-containing protein.	0.753
A0A1A0H1T1	A0A1A0HAD1	A0A1A0H1T1	A0A1A0HAD1	EF-hand.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.764
A0A1A0H1T1	A0A1A0HBN4	A0A1A0H1T1	A0A1A0HBN4	EF-hand.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.795
A0A1A0H1T1	A0A1A0HDZ0	A0A1A0H1T1	A0A1A0HDZ0	EF-hand.	Tricalbin.	0.592
A0A1A0H1T1	A0A1A0HE83	A0A1A0H1T1	A0A1A0HE83	EF-hand.	ANTH-domain-containing protein.	0.461
A0A1A0H1T1	A0A1A0HHN4	A0A1A0H1T1	A0A1A0HHN4	EF-hand.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.729
A0A1A0H1T1	A0A1A0HHW6	A0A1A0H1T1	A0A1A0HHW6	EF-hand.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.412
A0A1A0H1T1	A0A1A0HIC3	A0A1A0H1T1	A0A1A0HIC3	EF-hand.	Kinase-like protein.	0.677
A0A1A0H1T1	A0A1A0HJW2	A0A1A0H1T1	A0A1A0HJW2	EF-hand.	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	0.715
A0A1A0H1T1	A0A1A0HK35	A0A1A0H1T1	A0A1A0HK35	EF-hand.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.743