STRINGSTRING
dnaG dnaG dnaQ dnaQ mutS mutS dnaE dnaE holB holB dnaX dnaX mutL mutL dnaB dnaB dnaA-2 dnaA-2 dnaN dnaN dnaN-2 dnaN-2 recF recF ssb ssb holC holC topA topA holA holA polA polA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (622 aa)
dnaQBifunctional protein dnaQ; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (459 aa)
mutSDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (879 aa)
dnaEDNA polymerase III, alpha chain. (1187 aa)
holBDNA polymerase III, delta prime subunit. (326 aa)
dnaXDNA polymerase III, tau and gamma subunits (DNA elongation factor III); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (685 aa)
mutLEnzyme in methyl-directed mismatch repair, stimulates binding of Vsr and MutS to heteroduplex DNA; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (649 aa)
dnaBReplicative DNA helicase;chromosome replication, chain elongation; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (481 aa)
dnaA-2DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (469 aa)
dnaNDNA polymerase III, beta chain. (138 aa)
dnaN-2DNA polymerase III, beta chain. (233 aa)
recFDNA replication, recombinaison and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (360 aa)
ssbssDNA-binding protein controls activity of RecBCD nuclease; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (195 aa)
holCDNA polymerase III, chi subunit. (135 aa)
topADNA topoisomerase type I, omega protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, th [...] (878 aa)
holAPutative DNA polymerase III, delta subunit. (329 aa)
polADNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (923 aa)
Your Current Organism:
Acinetobacter pittii
NCBI taxonomy Id: 871585
Other names: A. pittii PHEA-2, Acinetobacter calcoaceticus PHEA-2, Acinetobacter calcoaceticus str. PHEA-2, Acinetobacter calcoaceticus strain PHEA-2, Acinetobacter pittii PHEA-2
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