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| | gcvA-3 | Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (275 aa) |
| | tagE | Glycosyltransferase. (513 aa) |
| | ADY80591.1 | Hypothetical protein. (552 aa) |
| | ADY80625.1 | Putative oxidoreductase with FAD/NAD(P)-binding domain. (399 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (688 aa) |
| | ADY80634.1 | Hypothetical protein. (166 aa) |
| | rpmF | 50S ribosomal protein; Belongs to the bacterial ribosomal protein bL32 family. (61 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (193 aa) |
| | rplY | 50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (98 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (622 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (158 aa) |
| | yeaT | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (326 aa) |
| | rpsL | 30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa) |
| | rpsG | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (712 aa) |
| | tuf1 | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa) |
| | algC | Phosphomannomutase. (472 aa) |
| | fecI | Sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (173 aa) |
| | def2 | Peptide deformylase 2; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (160 aa) |
| | gcvA | Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (287 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (225 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (520 aa) |
| | pbpA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (672 aa) |
| | dnaQ | Bifunctional protein dnaQ; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (459 aa) |
| | ttdR | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (306 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (883 aa) |
| | crp | cAMP-regulatory protein. (235 aa) |
| | ADY81038.1 | Hypothetical protein. (114 aa) |
| | htrB | Lipid A biosynthesis lauroyl acyltransferase (heat shock protein B); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (310 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (473 aa) |
| | kdsD | D-arabinose 5-phosphate isomerase. (325 aa) |
| | kdsC | 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (179 aa) |
| | yhjC | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (299 aa) |
| | fecI-2 | RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily. (168 aa) |
| | ADY81181.1 | RNA polymerase sigma-70 factor, ECF subfamily. (206 aa) |
| | ADY81205.1 | Amidase. (602 aa) |
| | paaX | Transcriptional regulator, PaaX family. (321 aa) |
| | ADY81298.1 | Putative LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | yafC | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | ltrA | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (311 aa) |
| | yhjC-2 | Putative LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | dnaE | DNA polymerase III, alpha chain. (1187 aa) |
| | ADY81524.1 | Putative Ser/Thr protein kinase-like phosphotransferase. (337 aa) |
| | mpg1 | Nucleotidyl transferase. (229 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (253 aa) |
| | holB | DNA polymerase III, delta prime subunit. (326 aa) |
| | rpsA | 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (557 aa) |
| | rpsT | 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa) |
| | ybaK | Putative transcription regulator; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (155 aa) |
| | y4mQ | Putative LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (283 aa) |
| | ADY81634.1 | Hypothetical protein. (54 aa) |
| | gatA | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Belongs to the amidase family. (369 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (285 aa) |
| | ispU | Undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (250 aa) |
| | frr | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (184 aa) |
| | impB | DNA-directed DNA polymerase. (441 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding protein; Cell wall formation. (344 aa) |
| | dnaX | DNA polymerase III, tau and gamma subunits (DNA elongation factor III); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (685 aa) |
| | glnS | glutaminyl-tRNA synthetase. (56 aa) |
| | glnS2 | glutaminyl-tRNA synthetase. (520 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (362 aa) |
| | yhjC-3 | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (202 aa) |
| | rpsF | 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (127 aa) |
| | rpsR | 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa) |
| | rplI | 50S ribosomal protein L9; Binds to the 23S rRNA. (148 aa) |
| | dnaB | Replicative DNA helicase;chromosome replication, chain elongation; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (481 aa) |
| | rpsU | 30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (71 aa) |
| | rpoH | RNA polymerase factor sigma-32; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (276 aa) |
| | mrcB | Bifunctional protein mrcB; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (798 aa) |
| | yhjC-4 | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (343 aa) |
| | rodA | Rod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (380 aa) |
| | tsf | Protein chain elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (291 aa) |
| | rpsB | 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (250 aa) |
| | ADY82445.1 | ATP synthase. (412 aa) |
| | ADY82472.1 | Hypothetical protein. (675 aa) |
| | efp | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family. (189 aa) |
| | rpmE | 50S ribosomal protein L31; Binds the 23S rRNA. (74 aa) |
| | dacC | D-ala-D-ala-carboxypeptidase; Belongs to the peptidase S11 family. (382 aa) |
| | dacD | Putative D-ala-D-ala-carboxypeptidase, penicillin-binding protein; Belongs to the peptidase S11 family. (440 aa) |
| | icaA | N-acetylglucosaminyltransferase. (416 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (605 aa) |
| | mltG | Putative periplasmic solute-binding protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (356 aa) |
| | ADY82620.1 | RNA polymerase factor sigma-70; Belongs to the sigma-70 factor family. ECF subfamily. (204 aa) |
| | htrB-2 | Putative lipid A biosynthesis lauroyl acyltransferase. (327 aa) |
| | poxA | Putative lysyl-tRNA synthetase. (324 aa) |
| | ycaN-2 | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | ADY82725.1 | Hypothetical protein. (551 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (337 aa) |
| | rpoD | Sigma D (sigma 70) factor of RNA polymerase, major sigma factor during exponential growth; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (636 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa) |
| | rpmA | 50S ribosomal protein L27. (66 aa) |
| | rplU | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (965 aa) |
| | ADY82780.1 | Hypothetical protein. (479 aa) |
| | ADY82781.1 | Hypothetical protein. (223 aa) |
| | yjdB | Lipid A phosphoethanolamine transferase. (549 aa) |
| | uppP3 | Undecaprenylpyrophosphate phosphatase (bacitracin resistance protein); Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (272 aa) |
| | ADY82807.1 | Hypothetical protein. (266 aa) |
| | gatC | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (104 aa) |
| | gatA-2 | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (492 aa) |
| | gatB | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (489 aa) |
| | ADY82842.1 | Hypothetical protein. (167 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (571 aa) |
| | ADY82858.1 | Hypothetical protein. (113 aa) |
| | ADY82929.1 | Hypothetical protein. (193 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (594 aa) |
| | cpsY | UDP-glucose-4-epimerase. (335 aa) |
| | ADY82947.1 | Hypothetical protein. (254 aa) |
| | ADY82948.1 | Hypothetical protein. (296 aa) |
| | lpsE | Glycosyltransferase, group 1 family protein. (344 aa) |
| | lpsC | Putative lipopolysaccharide core biosynthesis glycosyl transferase LpsC. (254 aa) |
| | ADY82984.1 | Hypothetical protein. (108 aa) |
| | yafC-2 | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (302 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso- diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (457 aa) |
| | ybjG | Undecaprenyl-diphosphatase. (112 aa) |
| | rpmH | 50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | dnaN | DNA polymerase III, beta chain. (138 aa) |
| | dnaN-2 | DNA polymerase III, beta chain. (233 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (410 aa) |
| | rplM | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | rpsI | 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (128 aa) |
| | rplQ | 50S ribosomal protein L17. (125 aa) |
| | rpoA | RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (335 aa) |
| | rpsD | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (128 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (118 aa) |
| | rpmJ | Ribosomal protein L36 family protein; Belongs to the bacterial ribosomal protein bL36 family. (38 aa) |
| | rplO | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa) |
| | rpmD | 50S ribosomal protein L30. (58 aa) |
| | rpsE | 30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (165 aa) |
| | rplR | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (116 aa) |
| | rplF | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa) |
| | rpsH | 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa) |
| | rpsN | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rplE | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (178 aa) |
| | rplX | 50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (105 aa) |
| | rplN | 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (68 aa) |
| | rpmC | 50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (65 aa) |
| | rplP | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (126 aa) |
| | rpsC | 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (265 aa) |
| | rplV | 50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (109 aa) |
| | rpsS | 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa) |
| | rplB | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa) |
| | rplW | 50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (106 aa) |
| | rplD | 50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (200 aa) |
| | rplC | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (212 aa) |
| | rpsJ | 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (111 aa) |
| | glyQ | glycyl-tRNA synthetase subunit alpha. (325 aa) |
| | glyS | glycyl-tRNA synthetase, beta chain. (689 aa) |
| | rplS | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (122 aa) |
| | rpsP | 30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (83 aa) |
| | rpoZ | RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (92 aa) |
| | ADY83231.1 | Hypothetical protein. (542 aa) |
| | ADY83232.1 | Hypothetical protein. (437 aa) |
| | ponA | Putative penicillin binding protein (PonA). (844 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (372 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (466 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (499 aa) |
| | ftsI | Septum formation, penicillin binding protein 3, peptidoglycan synthetase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (610 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (502 aa) |
| | yjjK | Putative ABC transporter ATP-binding protein. (534 aa) |
| | tex | RNA binding S1. (782 aa) |
| | glpM | Membrane protein required for efficient alginate biosynthesis. (113 aa) |
| | kdtA | 3-deoxy-D-manno-2-octulosonate transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (423 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (310 aa) |
| | ddlB | D-alanine-D-alanine ligase B; Cell wall formation. (308 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (482 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (365 aa) |
| | nusB | Transcription termination, L factor (N utilization substance protein B); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (149 aa) |
| | glmU | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa) |
| | murI | Putative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (266 aa) |
| | ADY83464.1 | Acyltransferase. (355 aa) |
| | yafC-3 | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (320 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (945 aa) |
| | gph2 | Putative phosphoglycolate phosphatase 2 (PGP 2). (233 aa) |
| | mviN | Probable lipid II flippase MurJ; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (516 aa) |
| | ptk | Tyrosine-protein kinase, autophosphorylates. (727 aa) |
| | vipA | Putative UDP-glucose/GDP-mannose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (431 aa) |
| | ADY83558.1 | Hypothetical protein. (316 aa) |
| | wbpD | Acetyltransferase. (192 aa) |
| | degT | Glutamine--scyllo-inositol transaminase; Belongs to the DegT/DnrJ/EryC1 family. (362 aa) |
| | ADY83562.1 | Glycosyl transferase, group 1 family protein. (389 aa) |
| | ADY83563.1 | Cytosol aminopeptidase. (466 aa) |
| | wecB | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (378 aa) |
| | ADY83566.1 | Hypothetical protein. (354 aa) |
| | rfbP | Undecaprenyl-phosphate galactosephosphotransferase. (155 aa) |
| | galU | UTP-glucose-1-phosphate uridylyltransferase. (291 aa) |
| | udg | Putative UDP-glucose 6-dehydrogenase (Ugd). (420 aa) |
| | oatA | Putative acyltransferase. (598 aa) |
| | cgmA | Sulfatase. (553 aa) |
| | manB | Putative bifunctional protein. (456 aa) |
| | bolA | Putative activator of morphogenic pathway (BolA), important in general stress response; Belongs to the BolA/IbaG family. (102 aa) |
| | argS | arginyl-tRNA synthetase. (596 aa) |
| | def | Peptide deformylase 1 (N-formylmethionylaminoacyl-tRNA deformylase, binds Zn(II)); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (176 aa) |
| | dinP | DNA polymerase IV, devoid of proofreading, damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa) |
| | holC | DNA polymerase III, chi subunit. (135 aa) |
| | pbpG | D-alanyl-D-alanine endopeptidase, penicillin-binding protein 7 and penicillin-binding protein 8; Belongs to the peptidase S11 family. (335 aa) |
| | murD | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (448 aa) |
| | ftsW | Cell division protein, stabililzes FtsZ ring; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (398 aa) |
| | gluQ | Putative glutamyl t-RNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (327 aa) |
| | ADY83749.1 | Hypothetical protein. (353 aa) |
| | algR | Alginate biosynthesis regulatory protein. (244 aa) |
| | tufA | tufA, tuf; elongation factor Tu. (396 aa) |
| | nusG | Transcription antitermination protein; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | rplK | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa) |
| | rplA | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (231 aa) |
| | rplJ | 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (168 aa) |
| | rplL | 50S ribosomal protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa) |
| | rpoB | RNA polymerase subunit B. (485 aa) |
| | rpoB-2 | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (842 aa) |
| | rpoC | DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1391 aa) |
| | nusA | nusA; Participates in both transcription termination and antitermination. (494 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (899 aa) |
| | ADY83839.1 | Hypothetical protein. (201 aa) |
| | ADY83840.1 | Hypothetical protein. (220 aa) |
| | rpsO | 30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | priA | Primosomal protein, ATP-dependent; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (742 aa) |
| | csaA | Protein secretion chaperone8. (112 aa) |
| | lnt | Apolipoprotein N-acyltransferase, copper homeostasis protein; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (519 aa) |
| | murI-2 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (288 aa) |
| | ADY83881.1 | Putative flavoprotein. (401 aa) |
| | rpmE2 | 50S ribosomal protein L31 type B. (84 aa) |
| | yhjC-6 | Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (298 aa) |
| | infA | Protein chain initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa) |
| | lpsB | Glycosyltransferase. (366 aa) |
| | htrB-3 | Lipid A biosynthesis lauroyl acyltransferase (heat shock protein B); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (311 aa) |
| | rpmG | 50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (51 aa) |
| | rpmB | 50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (248 aa) |
| | nagZ | beta-N-acetyl-D-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (339 aa) |
| | ADY83993.1 | Putative glycosyl transferase. (429 aa) |
| | ADY83999.1 | Hypothetical protein. (263 aa) |
| | hisS | histidyl-tRNA synthetase. (430 aa) |
| | ADY84012.1 | Glycosyl transferase, group 2 family protein. (246 aa) |
| | holA | Putative DNA polymerase III, delta subunit. (329 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (874 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (530 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (640 aa) |
| | infC | Protein chain initiation factor IF-3; Belongs to the IF-3 family. (112 aa) |
| | rpmI | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa) |
| | rplT | rplT; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha-subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (326 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (793 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (422 aa) |
| | polA | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (923 aa) |
| | rpoN | RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (491 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | gcvA-2 | Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (315 aa) |
