STRINGSTRING
dnaG dnaG coaD coaD cysD cysD cysNC cysNC dnaQ dnaQ mdcG mdcG dnaE dnaE glnD glnD mpg1 mpg1 kdsB kdsB holB holB cobU cobU cph2 cph2 ispD ispD cdsA cdsA mobA mobA impB impB dnaX dnaX cca cca yedQ yedQ ADY82601.1 ADY82601.1 ADY82928.1 ADY82928.1 glnE glnE dnaN dnaN dnaN-2 dnaN-2 cheR cheR rpoA rpoA rpoZ rpoZ pleD-4 pleD-4 pleD-5 pleD-5 glmU glmU ribF ribF rph rph galU galU ant ant yrdC yrdC dinP dinP holC holC rpoB rpoB rpoB-2 rpoB-2 rpoC rpoC pnp pnp holA holA pcnB pcnB polA polA rpoN rpoN
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (622 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (135 aa)
cysDSulfate adenylyltransferase subunit 2. (302 aa)
cysNCATP-sulfurylase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (537 aa)
dnaQBifunctional protein dnaQ; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (459 aa)
mdcGphosphoribosyl-dephospho-CoA transferase. (202 aa)
dnaEDNA polymerase III, alpha chain. (1187 aa)
glnDUridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (887 aa)
mpg1Nucleotidyl transferase. (229 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (253 aa)
holBDNA polymerase III, delta prime subunit. (326 aa)
cobUAdenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (172 aa)
cph2Putative two-component response regulator with GGDEF domain. (404 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (223 aa)
cdsAPhosphatidate cytidylyltransferase; Belongs to the CDS family. (274 aa)
mobAMolybdopterin-guanine dinucleotide synthase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (209 aa)
impBDNA-directed DNA polymerase. (441 aa)
dnaXDNA polymerase III, tau and gamma subunits (DNA elongation factor III); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (685 aa)
ccatRNA nucleotidyl transferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (412 aa)
yedQDiguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). (479 aa)
ADY82601.1Putative nicotinamide/nicotinate-nucleotide adenylyltransferase. (191 aa)
ADY82928.1Hypothetical protein. (480 aa)
glnEGlutamine synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] (916 aa)
dnaNDNA polymerase III, beta chain. (138 aa)
dnaN-2DNA polymerase III, beta chain. (233 aa)
cheRChemotaxis protein methyltransferase CheR. (366 aa)
rpoARNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (335 aa)
rpoZRNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (92 aa)
pleD-4Diguanylate cyclase response regulator. (566 aa)
pleD-5Sensor histidine kinase. (360 aa)
glmUBifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa)
ribFBifunctional protein ribF; Belongs to the ribF family. (333 aa)
rphRibonuclease PH (RNase PH), tRNA nucleotidyltransferase; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
galUUTP-glucose-1-phosphate uridylyltransferase. (291 aa)
antStreptomycin 3''-adenylyltransferase (AADA-like); Mediates bacterial resistance to the antibiotics streptomycin and spectomycin. (262 aa)
yrdCPutative SUA5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (189 aa)
dinPDNA polymerase IV, devoid of proofreading, damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa)
holCDNA polymerase III, chi subunit. (135 aa)
rpoBRNA polymerase subunit B. (485 aa)
rpoB-2DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (842 aa)
rpoCDNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1391 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (695 aa)
holAPutative DNA polymerase III, delta subunit. (329 aa)
pcnBpoly(A) polymerase I (PAP); Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (465 aa)
polADNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (923 aa)
rpoNRNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (491 aa)
Your Current Organism:
Acinetobacter pittii
NCBI taxonomy Id: 871585
Other names: A. pittii PHEA-2, Acinetobacter calcoaceticus PHEA-2, Acinetobacter calcoaceticus str. PHEA-2, Acinetobacter calcoaceticus strain PHEA-2, Acinetobacter pittii PHEA-2
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