STRINGSTRING
cyaD-2 cyaD-2 rpmJ rpmJ rpsK rpsK rpsD rpsD rplQ rplQ sspB sspB rpsI rpsI rplM rplM ADY83035.1 ADY83035.1 gyrB gyrB recF recF dnaA-2 dnaA-2 rpmH rpmH estA estA radC radC ADY82924.1 ADY82924.1 ADY82858.1 ADY82858.1 mreB-2 mreB-2 mreB mreB cafA cafA rplU rplU rpmA rpmA dnaA dnaA iga iga recO recO ADY82547.1 ADY82547.1 rpmE rpmE ADY82422.1 ADY82422.1 rpsB rpsB ADY82363.1 ADY82363.1 rpsU rpsU fis fis dnaB dnaB rplI rplI rpsR rpsR rpsF rpsF eutC eutC eutB eutB cbr4 cbr4 pldB pldB kynU kynU ADY82019.1 ADY82019.1 ADY81934.1 ADY81934.1 lysl lysl ADY81787.1 ADY81787.1 ADY81739.1 ADY81739.1 ADY81726.1 ADY81726.1 recR recR ADY81627.1 ADY81627.1 hup hup rpsT rpsT ADY81570.1 ADY81570.1 himD himD rpsA rpsA spoOJ spoOJ ADY81524.1 ADY81524.1 npdA npdA ADY81245.1 ADY81245.1 ADY81156.1 ADY81156.1 ADY81116.1 ADY81116.1 cyaD cyaD ADY81067.1 ADY81067.1 afmiD afmiD nth nth rpsG rpsG ADY80704.1 ADY80704.1 dnaG dnaG rplY rplY rpmF rpmF smc smc ADY80588.1 ADY80588.1 rpsC rpsC rplP rplP rplV rplV rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsN rpsN rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ ADY83186.1 ADY83186.1 rpsP rpsP ADY83235.1 ADY83235.1 ADY83323.1 ADY83323.1 guaB guaB ADY83404.1 ADY83404.1 dtd dtd pncA pncA rarA rarA ADY83712.1 ADY83712.1 rplK rplK rplA rplA rplJ rplJ rplL rplL recN recN ADY83818.1 ADY83818.1 infB infB rpsO rpsO priA priA ADY83882.1 ADY83882.1 rpmE2 rpmE2 rpmG rpmG rpmB rpmB ADY83978.1 ADY83978.1 edd edd pilF pilF rpmI rpmI rplT rplT himA himA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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cyaD-2Putative protein secretion efflux system, membrane fusion protein. (398 aa)
rpmJRibosomal protein L36 family protein; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (128 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rplQ50S ribosomal protein L17. (125 aa)
sspBClpXP protease specificity-enhancing factor. (144 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (128 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
ADY83035.1Hypothetical protein. (336 aa)
gyrBDNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] (822 aa)
recFDNA replication, recombinaison and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (360 aa)
dnaA-2DNA replication initiator protein, transcriptional regulator of replication and housekeeping genes; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (469 aa)
rpmH50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
estACarboxylesterase. (360 aa)
radCDNA repair protein, associated with replication forks; Belongs to the UPF0758 family. (239 aa)
ADY82924.1Putative cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa)
ADY82858.1Hypothetical protein. (113 aa)
mreB-2Rod shape-determining protein. (130 aa)
mreBRod shape-determining protein. (203 aa)
cafARibonuclease G, endoribonuclease G (cytoplasmic axial filament protein). (469 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmA50S ribosomal protein L27. (66 aa)
dnaAChromosomal replication initiator protein DnaA; Belongs to the DnaA family. HdA subfamily. (232 aa)
igaIgA-specific serine endopeptidase. (393 aa)
recODNA repair protein; Involved in DNA repair and RecF pathway recombination. (227 aa)
ADY82547.1Hypothetical protein. (378 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA. (74 aa)
ADY82422.1Hypothetical protein. (147 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (250 aa)
ADY82363.1Hypothetical protein. (182 aa)
rpsU30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (71 aa)
fisFis family transcriptional regulator, factor for inversion stimulation protein; DNA-binding protein for site-specific recombination, transcription of rRNA and tRNA operons and DNA replication; Belongs to the transcriptional regulatory Fis family. (70 aa)
dnaBReplicative DNA helicase;chromosome replication, chain elongation; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (481 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (148 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (127 aa)
eutCEthanolamine ammonia-lyase light chain; Belongs to the EutC family. (271 aa)
eutBEthanolamine ammonia-lyase, heavy chain. (441 aa)
cbr4Putative glucose 1-dehydrogenase. (253 aa)
pldBLysophospholipase. (342 aa)
kynUL-kynurenine hydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (416 aa)
ADY82019.1Hypothetical protein; Belongs to the SOS response-associated peptidase family. (184 aa)
ADY81934.1Short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
lyslSaccharopine dehydrogenase. (355 aa)
ADY81787.1Hypothetical protein. (199 aa)
ADY81739.1Hypothetical protein. (236 aa)
ADY81726.1Hypothetical protein. (144 aa)
recRRecombination protein, gap repair; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
ADY81627.1Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (109 aa)
hupDNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
ADY81570.1Hypothetical protein; Belongs to the SOS response-associated peptidase family. (244 aa)
himDIntegration host factor (IHF),beta subunit, site specific recombination; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
rpsA30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (557 aa)
spoOJChromosome partitioning protein; Belongs to the ParB family. (292 aa)
ADY81524.1Putative Ser/Thr protein kinase-like phosphotransferase. (337 aa)
npdANAD-dependent deacetylase (regulatory protein sirtuin family); Belongs to the sirtuin family. Class III subfamily. (235 aa)
ADY81245.1Ankyrin repeat protein. (215 aa)
ADY81156.1Esterase/lipase/thioesterase. (304 aa)
ADY81116.1Putative protein secretion efflux system, membrane fusion protein. (64 aa)
cyaDPutative protein secretion efflux system, membrane fusion protein(superfamily ABC, membrane). (345 aa)
ADY81067.1Hypothetical protein. (135 aa)
afmiDPutative esterase/lipase. (287 aa)
nthEndonuclease III DNA glycosylase/apyrimidinic (AP) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (224 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
ADY80704.1Lipase. (324 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (622 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (98 aa)
rpmF50S ribosomal protein; Belongs to the bacterial ribosomal protein bL32 family. (61 aa)
smcPutative chromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1149 aa)
ADY80588.1Hypothetical protein;putative exported protein. (341 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (265 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (126 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (109 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (65 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (68 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (105 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (178 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (116 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (165 aa)
rpmD50S ribosomal protein L30. (58 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (106 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (200 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (212 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (111 aa)
ADY83186.1Hypothetical protein. (425 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (83 aa)
ADY83235.1Hypothetical protein. (360 aa)
ADY83323.1Hypothetical protein. (127 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
ADY83404.1Hypothetical protein. (119 aa)
dtdD-tyrosyl tRNA(tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (147 aa)
pncABifunctional protein pncA. (214 aa)
rarAPutative ATPase. (421 aa)
ADY83712.1Hypothetical protein. (258 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (231 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (168 aa)
rplL50S ribosomal protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa)
recNProtein used in recombination and DNA repair; May be involved in recombinational repair of damaged DNA. (555 aa)
ADY83818.1Hypothetical protein. (436 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (899 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
priAPrimosomal protein, ATP-dependent; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (742 aa)
ADY83882.1Hypothetical protein. (136 aa)
rpmE250S ribosomal protein L31 type B. (84 aa)
rpmG50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (51 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
ADY83978.1Hypothetical protein. (184 aa)
eddEntner-Doudoroff pathway;edd; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (617 aa)
pilFType 4 fimbrial biogenesis protein. (255 aa)
rpmI50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rplTrplT; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
himAIntegration host factor (IHF), alpha subunit, DNA-binding protein, DNA replication; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (98 aa)
Your Current Organism:
Acinetobacter pittii
NCBI taxonomy Id: 871585
Other names: A. pittii PHEA-2, Acinetobacter calcoaceticus PHEA-2, Acinetobacter calcoaceticus str. PHEA-2, Acinetobacter calcoaceticus strain PHEA-2, Acinetobacter pittii PHEA-2
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