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| | AEF34095.1 | Aldehyde dehydrogenase (NAD+) dependent; Belongs to the aldehyde dehydrogenase family. (458 aa) |
| | AEF34113.1 | HpcH/HpaI; Belongs to the HpcH/HpaI aldolase family. (250 aa) |
| | ilvD | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (565 aa) |
| | pckA | Iron-regulated phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (606 aa) |
| | AEF34194.1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa) |
| | gabD1 | Succinate-semialdehyde dehydrogenase. (459 aa) |
| | sdhB_1 | Succinate dehydrogenase (iron-sulfur subunit) SdhB_1. (251 aa) |
| | sdhA | Succinate dehydrogenase (iron-sulfur subunit) SdhA_1. (640 aa) |
| | AEF34236.1 | Succinate dehydrogenase (membrane anchor subunit). (274 aa) |
| | aspC | Aspartate aminotransferase AspC. (425 aa) |
| | AEF34342.1 | Conserved hypothetical protein. (300 aa) |
| | fba | Fructose-bisphosphate aldolase Fba; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa) |
| | lpd | Dihydrolipoamide dehydrogenase Lpd. (466 aa) |
| | icl | Isocitrate lyase Icl. (428 aa) |
| | deoC | Deoxyribose-phosphate aldolase DeoC; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (227 aa) |
| | gpmA | Phosphoglycerate mutase 1 Gpm1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (249 aa) |
| | pfkA_1 | 6-phosphofructokinase PfkA_1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (374 aa) |
| | AEF34673.1 | Carbohydrate kinase. (307 aa) |
| | ilvG | Acetolactate synthase IlvG; Belongs to the TPP enzyme family. (568 aa) |
| | citA | Citrate synthase II CitA; Belongs to the citrate synthase family. (371 aa) |
| | gltA | Citrate synthase I GltA2; Belongs to the citrate synthase family. (431 aa) |
| | pgi | Glucose-6-phosphate isomerase Pgi; Belongs to the GPI family. (555 aa) |
| | sucC | succinyl-CoA synthetase (beta chain) SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (391 aa) |
| | sucD | succinyl-CoA synthetase (alpha chain) SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | AEF34953.1 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (450 aa) |
| | eno | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | fumC | Fumarase Fum; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa) |
| | glpX | Fructose 16-bisphosphatase GlpX. (328 aa) |
| | AEF35078.1 | Transcriptional regulatory protein. (479 aa) |
| | AEF35080.1 | Conserved hypothetical protein. (504 aa) |
| | AEF35081.1 | Methylisocitrate lyase 2; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (305 aa) |
| | gltA1 | Citrate synthase I GltA1; Belongs to the citrate synthase family. (372 aa) |
| | fadE20_1 | FadE20_1. (89 aa) |
| | AEF35084.1 | Conserved hypothetical protein. (577 aa) |
| | aldA_2 | Aldehyde dehydrogenase NAD dependent AldA_2; Belongs to the aldehyde dehydrogenase family. (510 aa) |
| | mdh | Malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | mez_1 | (NAD) dependent malate oxidoreductase Mez_1. (387 aa) |
| | kgd | Alpha-ketoglutarate decarboxylase Kgd. (1228 aa) |
| | thrA | Homoserine dehydrogenase ThrA. (434 aa) |
| | thrC | Threonine synthase ThrC; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (360 aa) |
| | thrB | Homoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (316 aa) |
| | glsA | Glutaminase; Belongs to the glutaminase family. (424 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component (alpha subunit) PdhA. (364 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component (beta subunit) PdhB. (349 aa) |
| | pdhC | Dihydrolipoamide S-acetyltransferase E2 component PdhC. (400 aa) |
| | rpiB | Ribose/galactose isomerase RpiB. (162 aa) |
| | porA | Pyruvate:ferredoxin oxidoreductase PorA alpha subunit. (616 aa) |
| | porB | Pyruvate:ferredoxin oxidoreductase PorB beta subunit. (361 aa) |
| | rbsK | Ribokinase-like domain-containing protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (286 aa) |
| | ilvX | Acetohydroxyacid synthase IlvX. (523 aa) |
| | aceE | Pyruvate dehydrogenase E1 component AceE; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (908 aa) |
| | sucB | Pyruvate dehydrogenase (E2 component) SucB. (587 aa) |
| | gcvT | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. (368 aa) |
| | ilvE | Branched-chain amino acid transaminase IlvE. (368 aa) |
| | AEF35698.1 | Glycerate kinase; Belongs to the glycerate kinase type-1 family. (365 aa) |
| | lpdB | Dihydrolipoamide dehydrogenase LpdB. (485 aa) |
| | mez | (NAD) dependent malate oxidoreductase Mez. (547 aa) |
| | gcvH | Glycine cleavage system H protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (133 aa) |
| | gcvB | Glycine dehydrogenase GcvB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (943 aa) |
| | glcB | Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (748 aa) |
| | gnd1 | 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (482 aa) |
| | mmpS5_2 | Transmembrane protein MmpS5_2. (121 aa) |
| | xfp | D-xylulose 5-phosphate Xfp. (801 aa) |
| | lldD2 | L-lactate dehydrogenase (cytochrome) LldD2. (415 aa) |
| | zwf1 | Glucose-6-phosphate 1-dehydrogenase Zwf1; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (471 aa) |
| | gnd2 | 6-phosphogluconate dehydrogenase decarboxylating Gnd2. (339 aa) |
| | aceAb | Isocitrate lyase AceAb. (765 aa) |
| | acn | Aconitate hydratase Acn. (932 aa) |
| | pykA | Pyruvate kinase PykA; Belongs to the pyruvate kinase family. (472 aa) |
| | ilvA | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (428 aa) |
| | acn-2 | Aconitate hydratase Acn. (940 aa) |
| | AEF36266.1 | Hypothetical protein. (62 aa) |
| | tkt | Transketolase Tkt; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (696 aa) |
| | tal | Transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (370 aa) |
| | zwf2 | Glucose-6-phosphate 1-dehydrogenase Zwf2; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (518 aa) |
| | opcA | OXPP cycle protein OpcA. (306 aa) |
| | devB | 6-phosphogluconolactonase DevB; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (246 aa) |
| | AEF36272.1 | Conserved hypothetical protein. (129 aa) |
| | tpiA | Triosephosphate isomerase Tpi; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa) |
| | pgk | Phosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (393 aa) |
| | gap | Glyceraldehyde 3-phosphate dehydrogenase Gap; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa) |
| | rpe | Ribulose-phosphate 3-epimerase Rpe; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | gabT | 4-aminobutyrate aminotransferase GabT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa) |
| | ppgK | Polyphosphate glucokinase PpgK. (272 aa) |
| | mqo | Malate:quinone oxidoreductase Mqo. (476 aa) |
| | fabG-6 | 3-oxoacyl-(acyl carrier protein) reductase. (258 aa) |
| | AEF36579.1 | Aldehyde dehydrogenase NAD dependent; Belongs to the aldehyde dehydrogenase family. (454 aa) |
| | AEF36580.1 | Amidotransferase. (239 aa) |
| | glnA3 | Glutamine synthetase GlnA3. (454 aa) |
| | lldD1_1 | L-lactate dehydrogenase (cytochrome) LldD1_1. (386 aa) |
| | AEF36650.1 | Acylphosphatase. (75 aa) |
| | pca | Pyruvate carboxylase Pca; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1127 aa) |
| | leuD | 3-isopropylmalate dehydratase (small subunit) LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa) |
| | leuC | 3-isopropylmalate dehydratase (large subunit) LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa) |
| | leuB | 3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (338 aa) |
| | serA1 | D-3-phosphoglycerate dehydrogenase SerA1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (524 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | ilvH | Acetolactate synthase (small subunit) IlvN. (170 aa) |
| | ilvB1 | Acetolactate synthase (large subunit) IlvB1. (580 aa) |
| | pfkA | 6-phosphofructokinase PfkA; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (343 aa) |
| | adh | NADP-dependent alcohol dehydrogenase Adh. (350 aa) |
| | ilvB1_2 | Acetolactate synthase (large subunit) IlvB1_2; Belongs to the TPP enzyme family. (578 aa) |
| | ackA | Acetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (381 aa) |
| | pta | Phosphate acetyltransferase Pta; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (700 aa) |
| | ilvB1_2-2 | Acetolactate synthase (large subunit) IlvB1_2; Belongs to the TPP enzyme family. (605 aa) |
| | lpdA | Dihydrolipoamide dehydrogenase LpdA. (493 aa) |
| | sdhC | Succinate dehydrogenase (cytochrome B-556 subunit) SdhC. (112 aa) |
| | sdhD | Succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD. (155 aa) |
| | sdhA-3 | Succinate dehydrogenase (flavoprotein subunit) SdhA. (575 aa) |
| | sdhB | Succinate dehydrogenase (iron-sulfur protein subunit) SdhB. (263 aa) |
| | icd2 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (744 aa) |
| | gadB-2 | Glutamate decarboxylase GadB; Belongs to the group II decarboxylase family. (461 aa) |
| | AEF37290.1 | Lignostilbene-alphabeta-dioxygenase. (211 aa) |
| | mmsA | Methylmalonate semialdehyde dehydrogenase MmsA. (506 aa) |
| | fadE9 | acyl-CoA dehydrogenase FadE9. (387 aa) |
| | mmsB-2 | 3-hydroxyisobutyrate dehydrogenase MmsB; Belongs to the HIBADH-related family. (291 aa) |
| | lldD1 | L-lactate dehydrogenase (cytochrome) LldD1. (397 aa) |
| | aldA_2-2 | Aldehyde dehydrogenase NAD dependent AldA_2; Belongs to the aldehyde dehydrogenase family. (507 aa) |
| | aldA-2 | NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (504 aa) |
| | gabD2 | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (517 aa) |
| | ppdK | Pyruvate phosphate dikinase PpdK. (534 aa) |
| | ppdK-2 | Pyruvate phosphate dikinase PpdK. (432 aa) |
| | acs | Acetyl-coenzyme A synthetase Acs; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa) |
| | leuA | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (604 aa) |
| | gltD | NADH-dependent glutamate synthase (small subunit) GltD. (483 aa) |
| | glnA1-2 | Glutamine synthetase GlnA1. (474 aa) |
| | AEF38261.1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa) |
