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ADZ08296.1 ADZ08296.1 ADZ08319.1 ADZ08319.1 ilvD ilvD ADZ08345.1 ADZ08345.1 ADZ08346.1 ADZ08346.1 ilvC ilvC ilvE ilvE leuC leuC leuD leuD ADZ08423.1 ADZ08423.1 ADZ08632.1 ADZ08632.1 ADZ08634.1 ADZ08634.1 ADZ08647.1 ADZ08647.1 ADZ08679.1 ADZ08679.1 ADZ08680.1 ADZ08680.1 ADZ08681.1 ADZ08681.1 ADZ08682.1 ADZ08682.1 ADZ08736.1 ADZ08736.1 ADZ08737.1 ADZ08737.1 ADZ08738.1 ADZ08738.1 ADZ08739.1 ADZ08739.1 ADZ08740.1 ADZ08740.1 ADZ08741.1 ADZ08741.1 ADZ08742.1 ADZ08742.1 ADZ08817.1 ADZ08817.1 ADZ08818.1 ADZ08818.1 ADZ08830.1 ADZ08830.1 ADZ08832.1 ADZ08832.1 sucD sucD ADZ08915.1 ADZ08915.1 ADZ08995.1 ADZ08995.1 ADZ09693.1 ADZ09693.1 ADZ09694.1 ADZ09694.1 ADZ09877.1 ADZ09877.1 ADZ09939.1 ADZ09939.1 ADZ10085.1 ADZ10085.1 ADZ10102.1 ADZ10102.1 ADZ10118.1 ADZ10118.1 hacB hacB ADZ10255.1 ADZ10255.1 leuC-2 leuC-2 ADZ10290.1 ADZ10290.1 ADZ10331.1 ADZ10331.1 ADZ10332.1 ADZ10332.1 cimA cimA sucC sucC ADZ10619.1 ADZ10619.1 ADZ10620.1 ADZ10620.1 ADZ10621.1 ADZ10621.1 ADZ10622.1 ADZ10622.1 ADZ10663.1 ADZ10663.1 ADZ10664.1 ADZ10664.1 ADZ10665.1 ADZ10665.1 ADZ10666.1 ADZ10666.1 ADZ10667.1 ADZ10667.1 ADZ10668.1 ADZ10668.1 ADZ10669.1 ADZ10669.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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textmining
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Your Input:
ADZ08296.1L-aspartate oxidase; KEGG: mfv:Mfer_0085 thiol-driven fumarate reductase, flavoprotein subunit; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal. (558 aa)
ADZ08319.1SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; TIGRFAM: Isopropylmalate/citramalate/homocitrate synthase; KEGG: mth:MTH1481 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa)
ilvDPFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: mmg:MTBMA_c00370 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (551 aa)
ADZ08345.1TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: mth:MTH1444 acetolactate synthase catalytic subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (577 aa)
ADZ08346.1KEGG: mfv:Mfer_0053 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (166 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa)
ADZ08423.1KEGG: mru:mru_0103 3-isopropylmalate dehydrogenase LeuB; PFAM: Isocitrate/isopropylmalate dehydrogenase. (334 aa)
ADZ08632.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (765 aa)
ADZ08634.1PFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; KEGG: msi:Msm_0929 fumarate hydratase, FumA. (167 aa)
ADZ08647.1TIGRFAM: Oxaloacetate decarboxylase, alpha subunit; KEGG: mmg:MTBMA_c14900 pyruvate carboxylase, subunit B; PFAM: Carboxylase, conserved domain; Pyruvate carboxyltransferase; Biotin/lipoyl attachment. (570 aa)
ADZ08679.1MmgE/PrpD family protein; PFAM: MmgE/PrpD; KEGG: mfv:Mfer_0669 MmgE/PrpD family protein. (444 aa)
ADZ08680.1KEGG: mth:MTH964 hypothetical protein. (299 aa)
ADZ08681.1KEGG: mth:MTH963 fumarate hydratase, class I related protein; TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain. (285 aa)
ADZ08682.1PFAM: Citrate synthase-like; KEGG: mmg:MTBMA_c13480 citrate synthase. (273 aa)
ADZ08736.1TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; KEGG: mth:MTH1735 fumarate hydratase; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain. (282 aa)
ADZ08737.1PFAM: 4Fe-4S binding domain; KEGG: mth:MTH1736 formate hydrogenlyase, iron-sulfur subunit 2. (143 aa)
ADZ08738.1PFAM: 4Fe-4S binding domain; KEGG: mmg:MTBMA_c03120 HycB-related protein. (166 aa)
ADZ08739.1KEGG: mth:MTH1738 pyruvate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (288 aa)
ADZ08740.1KEGG: mmg:MTBMA_c03140 pyruvate synthase, subunit A; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (382 aa)
ADZ08741.1KEGG: mmg:MTBMA_c03150 pyruvate synthase, subunit D; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S binding domain. (80 aa)
ADZ08742.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: mth:MTH1740 pyruvate ferredoxin oxidoreductase subunit gamma/delta; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (177 aa)
ADZ08817.1KEGG: mfv:Mfer_0624 acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain. (536 aa)
ADZ08818.1TIGRFAM: Acetate-CoA ligase; KEGG: mmg:MTBMA_c01900 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase. (649 aa)
ADZ08830.1HAMAP: Malate dehydrogenase, NAD-dependent; KEGG: mmg:MTBMA_c06400 malate dehydrogenase; PFAM: Lactate/malate dehydrogenase, N-terminal; Lactate/malate dehydrogenase, C-terminal; Belongs to the LDH/MDH superfamily. (315 aa)
ADZ08832.1TIGRFAM: Isopropylmalate/isohomocitrate dehydrogenase; KEGG: mth:MTH184 multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (329 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (286 aa)
ADZ08915.1TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein; KEGG: mmg:MTBMA_c04210 thiol:fumarate reductase, subunit B; PFAM: Cysteine-rich domain; Ferredoxin. (498 aa)
ADZ08995.1TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; KEGG: mst:Msp_0791 fumarate hydratase; PFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain. (182 aa)
ADZ09693.1KEGG: mmg:MTBMA_c09230 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit alpha; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (573 aa)
ADZ09694.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: ppd:Ppro_0548 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (288 aa)
ADZ09877.1CoA-binding domain protein; KEGG: mbu:Mbur_1347 acyl-CoA synthetase; PFAM: CoA-binding; SMART: CoA-binding. (695 aa)
ADZ09939.1acetate/CoA ligase; PFAM: AMP-dependent synthetase/ligase; manually curated; KEGG: mth:MTH217 acetyl-CoA synthetase; TIGRFAM: Acetate-CoA ligase. (634 aa)
ADZ10085.1Methylisocitrate lyase; KEGG: ccb:Clocel_0283 2,3-dimethylmalate lyase. (276 aa)
ADZ10102.1PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: mru:mru_0603 N-carbamoyl-D-amino acid amidohydrolase AguB. (280 aa)
ADZ10118.1TIGRFAM: Acetate-CoA ligase; KEGG: mfv:Mfer_0074 acetyl-coenzyme a synthetase; PFAM: AMP-dependent synthetase/ligase. (633 aa)
hacB3-isopropylmalate dehydratase small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD f [...] (163 aa)
ADZ10255.1Acetolactate synthase; KEGG: mth:MTH476 pyruvate dehydrogenase / acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Rubredoxin-type Fe(Cys)4 protein; Thiamine pyrophosphate enzyme, central domain. (585 aa)
leuC-23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa)
ADZ10290.1TIGRFAM: Isopropylmalate/citramalate/homocitrate synthase; KEGG: mmg:MTBMA_c02150 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa)
ADZ10331.1TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein; KEGG: mmh:Mmah_0726 succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: Ferredoxin. (257 aa)
ADZ10332.1TIGRFAM: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; KEGG: mmh:Mmah_0725 succinate dehydrogenase subunit A; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal. (596 aa)
cimAIsopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (501 aa)
sucCSuccinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (368 aa)
ADZ10619.1KEGG: mru:mru_1826 2-oxoglutarate ferredoxin oxidoreductase subunit gamma KorC; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (182 aa)
ADZ10620.1KEGG: mth:MTH1034 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (288 aa)
ADZ10621.1KEGG: mmg:MTBMA_c14150 2-oxoglutarate synthase, subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal. (375 aa)
ADZ10622.1PFAM: 4Fe-4S binding domain; KEGG: mfv:Mfer_0036 2-oxoglutarate ferredoxin oxidoreductase, delta subunit. (69 aa)
ADZ10663.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: mmg:MTBMA_c09240 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (286 aa)
ADZ10664.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: mmg:MTBMA_c09230 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (571 aa)
ADZ10665.1PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: mmp:MMP1271 2-oxoisovalerate oxidoreductase subunit alpha. (481 aa)
ADZ10666.13-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: mmp:MMP1272 2-ketoisovalerate ferredoxin reductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (351 aa)
ADZ10667.1PFAM: 4Fe-4S binding domain; KEGG: mmq:MmarC5_0318 ketoisovalerate ferredoxin oxidoreductase, delta subunit. (102 aa)
ADZ10668.1Butyrate--CoA ligase; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase/ligase. (557 aa)
ADZ10669.1KEGG: mmz:MmarC7_0521 cupin 2 domain-containing protein; PFAM: Cupin 2, conserved barrel; Helix-turn-helix type 3; SMART: Helix-turn-helix type 3. (184 aa)
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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