STRINGSTRING
mtd mtd ADZ08416.1 ADZ08416.1 ADZ08471.1 ADZ08471.1 ADZ08472.1 ADZ08472.1 ADZ08473.1 ADZ08473.1 ftr ftr ADZ08600.1 ADZ08600.1 ADZ08601.1 ADZ08601.1 ADZ08602.1 ADZ08602.1 ADZ08603.1 ADZ08603.1 ADZ08604.1 ADZ08604.1 ADZ08605.1 ADZ08605.1 mtrE mtrE mtrD mtrD mtrC mtrC mtrB mtrB mtrA mtrA mtrF mtrF mtrG mtrG mtrH mtrH ADZ08620.1 ADZ08620.1 ADZ08621.1 ADZ08621.1 ADZ08622.1 ADZ08622.1 ADZ08623.1 ADZ08623.1 mer mer ADZ08825.1 ADZ08825.1 ADZ08890.1 ADZ08890.1 ADZ08891.1 ADZ08891.1 ADZ08951.1 ADZ08951.1 ADZ08952.1 ADZ08952.1 ADZ09113.1 ADZ09113.1 ADZ09448.1 ADZ09448.1 ADZ09449.1 ADZ09449.1 ADZ09450.1 ADZ09450.1 ADZ09491.1 ADZ09491.1 ADZ09492.1 ADZ09492.1 ADZ09532.1 ADZ09532.1 ADZ10492.1 ADZ10492.1 ADZ10493.1 ADZ10493.1 ADZ10494.1 ADZ10494.1 ADZ10495.1 ADZ10495.1 ADZ10690.1 ADZ10690.1 ADZ10691.1 ADZ10691.1 ADZ10692.1 ADZ10692.1 ADZ10719.1 ADZ10719.1 ADZ10720.1 ADZ10720.1 ADZ10721.1 ADZ10721.1 ADZ10722.1 ADZ10722.1 ADZ10723.1 ADZ10723.1 ADZ10724.1 ADZ10724.1 ADZ10725.1 ADZ10725.1 ADZ10726.1 ADZ10726.1 ADZ10727.1 ADZ10727.1 ADZ10728.1 ADZ10728.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtdF420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa)
ADZ08416.14Fe-4S ferredoxin iron-sulfur binding domain-containing protein; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (658 aa)
ADZ08471.1KEGG: mmg:MTBMA_c16850 F420-reducing hydrogenase, subunit delta; TIGRFAM: Peptidase A31, coenzyme F420-reducing hydrogenase delta subunit; Peptidase A31, hydrogen uptake protein; PFAM: Peptidase A31, hydrogen uptake protein. (156 aa)
ADZ08472.1TIGRFAM: Coenzyme F420 hydrogenase, subunit gamma; KEGG: mmg:MTBMA_c16840 F420-reducing hydrogenase, subunit gamma; PFAM: NADH:ubiquinone oxidoreductase-like, 20kDa subunit; 4Fe-4S binding domain. (261 aa)
ADZ08473.1TIGRFAM: Coenzyme F420 hydrogenase, subunit beta; KEGG: mmg:MTBMA_c16830 F420-reducing hydrogenase, subunit beta; PFAM: Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal; Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal. (294 aa)
ftrFormylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa)
ADZ08600.1Methanogenesis marker protein 10; KEGG: mmg:MTBMA_c15530 Fe-S oxidoreductase; TIGRFAM: Putative methanogenesis marker protein 10; PFAM: Domain of unknown function DUF512; Radical SAM. (423 aa)
ADZ08601.1TIGRFAM: Methyl-coenzyme M reductase, beta subunit; KEGG: mmg:MTBMA_c15520 methyl-coenzyme M reductase I, subunit beta; PFAM: Methyl-coenzyme M reductase, beta subunit, C-terminal; Methyl-coenzyme M reductase, beta subunit, N-terminal. (441 aa)
ADZ08602.1KEGG: mth:MTH1167 methyl coenzyme M reductase I, D protein; TIGRFAM: Methyl-coenzyme M reductase, protein D; PFAM: Methyl-coenzyme M reductase, protein D. (144 aa)
ADZ08603.1KEGG: mmg:MTBMA_c15500 methyl-coenzyme M reductase I, subunit epsilon; TIGRFAM: Methyl-coenzyme M reductase, protein C; PFAM: Methyl-coenzyme M reductase, protein C. (198 aa)
ADZ08604.1TIGRFAM: Methyl-coenzyme M reductase, gamma subunit; KEGG: mth:MTH1165 methyl coenzyme M reductase I, gamma subunit; PFAM: Methyl-coenzyme M reductase, gamma subunit. (249 aa)
ADZ08605.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa)
mtrETetrahydromethanopterin S-methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (293 aa)
mtrDTetrahydromethanopterin S-methyltransferase subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (243 aa)
mtrCTetrahydromethanopterin S-methyltransferase, subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (270 aa)
mtrBTetrahydromethanopterin S-methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (101 aa)
mtrATetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (239 aa)
mtrFTetrahydromethanopterin S-methyltransferase, F subunit; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (67 aa)
mtrGTetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (82 aa)
mtrHTetrahydromethanopterin S-methyltransferase subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (310 aa)
ADZ08620.1PFAM: Methyl-viologen-reducing hydrogenase, delta subunit; KEGG: mth:MTH1136 methyl viologen-reducing hydrogenase, delta subunit. (142 aa)
ADZ08621.1PFAM: NADH:ubiquinone oxidoreductase-like, 20kDa subunit; KEGG: msi:Msm_1000 methyl viologen-reducing hydrogenase, gamma subunit, MvhG. (309 aa)
ADZ08622.1Hydrogen dehydrogenase; KEGG: mmg:MTBMA_c15170 F420-non-reducing hydrogenase, subunit A; PFAM: Nickel-dependent hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (470 aa)
ADZ08623.1PFAM: 4Fe-4S binding domain; KEGG: mth:MTH1133 polyferredoxin (MvhB). (412 aa)
mer5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa)
ADZ08825.1Coenzyme F420 hydrogenase; KEGG: mmg:MTBMA_c06440 F420-dependent glutamate synthase; PFAM: Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal; 4Fe-4S binding domain; Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal. (367 aa)
ADZ08890.1Hydrogen dehydrogenase; KEGG: mpd:MCP_2492 F420-non-reducing hydrogenase subunit A; PFAM: Nickel-dependent hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (482 aa)
ADZ08891.1PFAM: NADH:ubiquinone oxidoreductase-like, 20kDa subunit; KEGG: mpd:MCP_2493 F420-non-reducing hydrogenase subunit G. (303 aa)
ADZ08951.1KEGG: mth:MTH1878 heterodisulfide reductase, subunit C; TIGRFAM: CoB--CoM heterodisulphide reductase, subunit C. (331 aa)
ADZ08952.1TIGRFAM: CoB--CoM heterodisulphide reductase, subunit B; KEGG: mmg:MTBMA_c04500 CoB-CoM heterodisulfide reductase, subunit B; PFAM: Cysteine-rich domain. (298 aa)
ADZ09113.1PFAM: Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal; Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal; 4Fe-4S binding domain; KEGG: mth:MTH341 coenzyme F420-reducing hydrogenase, beta subunit-like protein. (426 aa)
ADZ09448.1Methyl-viologen-reducing hydrogenase delta subunit; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (777 aa)
ADZ09449.1KEGG: msi:Msm_0083 heterodisulfide reductase, subunit B, HdrB; PFAM: Cysteine-rich domain. (331 aa)
ADZ09450.1Heterodisulfide reductase subunit C, HdrC2; KEGG: mst:Msp_0125 HdrC2. (196 aa)
ADZ09491.1KEGG: msi:Msm_0083 heterodisulfide reductase, subunit B, HdrB; PFAM: Cysteine-rich domain. (314 aa)
ADZ09492.1Heterodisulfide reductase subunit C, HdrC2; KEGG: mst:Msp_0125 HdrC2. (195 aa)
ADZ09532.1KEGG: mth:MTH384 hypothetical protein. (98 aa)
ADZ10492.1TIGRFAM: Methyl-coenzyme M reductase, beta subunit; KEGG: mfv:Mfer_0731 methyl-coenzyme m reductase, beta subunit; PFAM: Methyl-coenzyme M reductase, beta subunit, C-terminal; Methyl-coenzyme M reductase, beta subunit, N-terminal. (443 aa)
ADZ10493.1KEGG: mst:Msp_0319 MrtD; TIGRFAM: Methyl-coenzyme M reductase, protein D; PFAM: Methyl-coenzyme M reductase, protein D. (162 aa)
ADZ10494.1TIGRFAM: Methyl-coenzyme M reductase, gamma subunit; KEGG: mth:MTH1130 methyl coenzyme M reductase II, gamma subunit; PFAM: Methyl-coenzyme M reductase, gamma subunit. (264 aa)
ADZ10495.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa)
ADZ10690.1Methyl-viologen-reducing hydrogenase delta subunit; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (771 aa)
ADZ10691.1KEGG: rci:LRC438 putative heterodisulfide reductase, subunit B; PFAM: Cysteine-rich domain. (306 aa)
ADZ10692.1PFAM: 4Fe-4S binding domain; KEGG: mpd:MCP_1991 putative CoB--CoM heterodisulfide reductase iron-sulfur subunit C. (204 aa)
ADZ10719.1PFAM: Protein of unknown function DUF2097; KEGG: mru:mru_0347 hypothetical protein. (102 aa)
ADZ10720.1PFAM: Protein of unknown function DUF2097; KEGG: mru:mru_0346 hypothetical protein. (100 aa)
ADZ10721.1TIGRFAM: Formylmethanofuran dehydrogenase subunit C; KEGG: mru:mru_0345 tungsten formylmethanofuran dehydrogenase subunit C FwdC; PFAM: Glutamate synthase, alpha subunit, C-terminal. (270 aa)
ADZ10722.1KEGG: mru:mru_0344 tungsten formylmethanofuran dehydrogenase subunit A FwdA; TIGRFAM: Formylmethanofuran dehydrogenase, subunit A; PFAM: Amidohydrolase 3. (569 aa)
ADZ10723.1TIGRFAM: Formylmethanofuran dehydrogenase, subunit B; KEGG: msi:Msm_1412 tungsten formylmethanofuran dehydrogenase, subunit B, FwdB; PFAM: Molybdopterin oxidoreductase. (452 aa)
ADZ10724.1Molybdopterin dinucleotide-binding region; PFAM: Molydopterin dinucleotide-binding domain; KEGG: msi:Msm_1411 tungsten formylmethanofuran dehydrogenase, subunit D, FwdD. (178 aa)
ADZ10725.14Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: 4Fe-4S binding domain; KEGG: mru:mru_0341 tungsten formylmethanofuran dehydrogenase subunit G FwdG. (76 aa)
ADZ10726.14Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: 4Fe-4S binding domain; KEGG: mru:mru_0340 tungsten formylmethanofuran dehydrogenase subunit F FwdF. (347 aa)
ADZ10727.1PFAM: Helix-turn-helix type 3; 4Fe-4S binding domain; KEGG: mth:MTH1553 tungsten formylmethanofuran dehydrogenase, subunit H. (149 aa)
ADZ10728.1TIGRFAM: Formate dehydrogenase, alpha subunit; PFAM: Molybdopterin oxidoreductase; Molybdopterin oxidoreductase, Fe4S4 domain; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; 4Fe-4S binding domain; Molydopterin dinucleotide-binding domain; KEGG: mth:MTH1552 formate dehydrogenase, alpha subunit-like protein; SMART: Molybdopterin oxidoreductase, Fe4S4 domain; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding. (901 aa)
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
Server load: low (18%) [HD]