STRINGSTRING
hisG hisG hisH hisH trpB trpB hisB hisB ADZ08343.1 ADZ08343.1 purD purD surE surE ADZ08355.1 ADZ08355.1 pyrB pyrB dapF dapF lysA lysA argD argD hisF hisF purL purL glyA glyA purE purE hpt hpt argG argG ADZ08540.1 ADZ08540.1 ADZ08552.1 ADZ08552.1 pyrD pyrD ADZ08560.1 ADZ08560.1 hisE hisE purM purM pyrC pyrC ADZ08635.1 ADZ08635.1 ADZ08772.1 ADZ08772.1 tmk tmk ADZ08803.1 ADZ08803.1 ADZ08815.1 ADZ08815.1 argH argH ADZ08864.1 ADZ08864.1 hisI hisI aroE aroE aroD aroD dcd dcd ADZ08929.1 ADZ08929.1 pyrE pyrE ADZ08964.1 ADZ08964.1 dapL dapL purA purA aroA aroA pyrI pyrI argC argC argB argB argJ argJ guaB guaB ADZ09232.1 ADZ09232.1 ADZ09300.1 ADZ09300.1 aroC aroC pyrG pyrG ADZ09417.1 ADZ09417.1 ADZ09420.1 ADZ09420.1 ADZ09422.1 ADZ09422.1 ADZ09423.1 ADZ09423.1 ADZ09428.1 ADZ09428.1 ADZ09445.1 ADZ09445.1 cysS cysS ADZ09455.1 ADZ09455.1 metXA metXA glyA-2 glyA-2 ADZ09510.1 ADZ09510.1 ADZ09541.1 ADZ09541.1 hisD hisD ADZ09625.1 ADZ09625.1 ADZ09972.1 ADZ09972.1 asd asd dapB dapB dapA dapA ADZ10127.1 ADZ10127.1 ADZ10129.1 ADZ10129.1 aroK aroK hisA hisA ADZ10185.1 ADZ10185.1 ADZ10186.1 ADZ10186.1 pyrF pyrF trpD trpD trpA trpA trpB-2 trpB-2 trpF trpF ADZ10265.1 ADZ10265.1 ADZ10266.1 ADZ10266.1 trpE trpE ADZ10282.1 ADZ10282.1 ADZ10284.1 ADZ10284.1 ADZ10294.1 ADZ10294.1 purF purF glmS glmS ADZ10329.1 ADZ10329.1 ADZ10330.1 ADZ10330.1 purC purC purS purS purQ purQ ADZ10346.1 ADZ10346.1 uppS uppS thyA thyA ADZ10411.1 ADZ10411.1 carA carA carB carB glmM glmM hisC hisC ADZ10510.1 ADZ10510.1 pyrH pyrH guaAA guaAA guaAB guaAB ADZ10737.1 ADZ10737.1 ADZ10744.1 ADZ10744.1
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hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa)
hisBHAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: mru:mru_2139 bifunctional imidazoleglycerol-phosphate dehydratase HisB; PFAM: Imidazoleglycerol-phosphate dehydratase. (191 aa)
ADZ08343.1PFAM: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; TIGRFAM: Ornithine carbamoyltransferase; HAMAP: Ornithine carbamoyltransferase; KEGG: mfv:Mfer_0050 ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (300 aa)
purDPhosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: mfv:Mfer_0051 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (441 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa)
ADZ08355.1Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (186 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase, eukaryotic; KEGG: mmg:MTBMA_c00020 aspartate carbamoyltransferase. (307 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (292 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (428 aa)
argDPFAM: Aminotransferase class-III; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: mfv:Mfer_0532 acetylornithine aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (274 aa)
purLPhosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (717 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (421 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (340 aa)
hptPhosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (190 aa)
argGPFAM: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: mth:MTH1254 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (393 aa)
ADZ08540.1PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: mmg:MTBMA_c16200 homoserine dehydrogenase. (426 aa)
ADZ08552.1KEGG: mmg:MTBMA_c16050 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (276 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (300 aa)
ADZ08560.1PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase, FAD-binding domain; KEGG: mfv:Mfer_1174 oxidoreductase fad/nad(P)-binding domain protein. (264 aa)
hisETIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; KEGG: msi:Msm_1103 phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like. (97 aa)
purMTIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: msi:Msm_1039 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein; AIR synthase-related protein, C-terminal. (342 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (432 aa)
ADZ08635.1TIGRFAM: Uracil phosphoribosyl transferase; KEGG: mmg:MTBMA_c14980 uracil phosphoribosyltransferase. (214 aa)
ADZ08772.1PFAM: Thymidylate kinase; KEGG: mmg:MTBMA_c14850 thymidylate kinase-related protein. (197 aa)
tmkPFAM: Thymidylate kinase; TIGRFAM: Thymidylate kinase; HAMAP: Thymidylate kinase; KEGG: msi:Msm_0520 thymidylate kinase, Tmk. (191 aa)
ADZ08803.1dUTP diphosphatase; KEGG: msi:Msm_0687 deoxycytidine-triphosphate deaminase, dcd; PFAM: DeoxyUTP pyrophosphatase domain. (151 aa)
ADZ08815.1Serine--pyruvate transaminase; KEGG: mmg:MTBMA_c01880 aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase. (389 aa)
argHPFAM: Lyase 1, N-terminal; TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: mmg:MTBMA_c07190 argininosuccinate lyase. (469 aa)
ADZ08864.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (399 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (132 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (225 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (201 aa)
ADZ08929.1Manually curated; KEGG: mfv:Mfer_0136 orotate phosphoribosyltransferase. (53 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (174 aa)
ADZ08964.1KEGG: mmg:MTBMA_c04630 aspartate aminotransferase; PFAM: Aminotransferase, class I/classII. (372 aa)
dapLLL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (340 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (420 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (155 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (336 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (398 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (495 aa)
ADZ09232.1KEGG: mfv:Mfer_0255 thymidylate synthase, methanogen type. (215 aa)
ADZ09300.1TIGRFAM: Bacterial carbamate kinase; KEGG: mem:Memar_0247 carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (325 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
ADZ09417.1KEGG: mst:Msp_0487 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding. (339 aa)
ADZ09420.1KEGG: mst:Msp_0490 putative asparagine synthetase; TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (495 aa)
ADZ09422.1KEGG: mvn:Mevan_0177 serine O-acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (237 aa)
ADZ09423.1TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: mru:mru_1574 cysteine synthase CysKM1; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (328 aa)
ADZ09428.1Cystathionine beta-lyase; KEGG: dly:Dehly_0142 class I and II aminotransferase; PFAM: Aminotransferase, class I/classII. (400 aa)
ADZ09445.1KEGG: mmg:MTBMA_c05680 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase, catalytic domain; PFAM: ATP phosphoribosyltransferase, catalytic domain. (329 aa)
cysSSMART: Cysteinyl-tRNA synthetase, class Ia, DALR; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: mst:Msp_0124 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; Belongs to the class-I aminoacyl-tRNA synthetase family. (467 aa)
ADZ09455.1TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: mbu:Mbur_0797 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (439 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (489 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (421 aa)
ADZ09510.1KEGG: bba:Bd3795 cystathionine gamma-lyase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (377 aa)
ADZ09541.1KEGG: cpy:Cphy_3485 peptidase T-like protein; TIGRFAM: Peptidase M20B, peptidase T; PFAM: Peptidase M20, dimerisation; Peptidase M20. (381 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (467 aa)
ADZ09625.1PFAM: Xanthine/uracil/vitamin C permease; KEGG: mpd:MCP_1361 xanthine/uracil/vitamin C permease family protein. (485 aa)
ADZ09972.1Glutamine--fructose-6-phosphate transaminase (isomerizing); KEGG: mth:MTH860 glucosamine--fructose-6-phosphate aminotransferase; PFAM: Sugar isomerase (SIS). (341 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
ADZ10127.1KEGG: mmg:MTBMA_c11980 aspartate kinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family. (406 aa)
ADZ10129.1TIGRFAM: Chorismate mutase, archaeal; PFAM: Chorismate mutase, type II; KEGG: mfv:Mfer_0679 chorismate mutase, type II; SMART: Chorismate mutase. (97 aa)
aroKPFAM: GHMP kinase; GHMP kinase, C-terminal; TIGRFAM: Shikimate kinase, archaea; HAMAP: Shikimate kinase; KEGG: mfv:Mfer_0680 shikimate kinase. (301 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: mmg:MTBMA_c12400 phosphoribosylformimino-5-aminoimidazole ribonucleotide isomerase. (245 aa)
ADZ10185.1Protein of unknown function DUF39; KEGG: mmg:MTBMA_c12520 CBS domain containing protein; PFAM: Domain of unknown function DUF39; Cystathionine beta-synthase, core; SMART: Cystathionine beta-synthase, core. (514 aa)
ADZ10186.1NIL domain-containing protein; KEGG: mmg:MTBMA_c12510 conserved hypothetical protein containing a ferredoxin domain; PFAM: NIL domain; 4Fe-4S binding domain; SMART: NIL domain. (128 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (216 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa)
trpB-2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mfv:Mfer_0095 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (235 aa)
ADZ10265.1KEGG: mfv:Mfer_0096 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase. (278 aa)
ADZ10266.1TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; KEGG: mfv:Mfer_0097 anthranilate synthase, component II; PFAM: Glutamine amidotransferase class-I, C-terminal. (191 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (461 aa)
ADZ10282.1KEGG: mfv:Mfer_0622 prephenate dehydrogenase. (435 aa)
ADZ10284.1Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. (417 aa)
ADZ10294.1TIGRFAM: Phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: mru:mru_0388 phosphoserine phosphatase SerB; PFAM: Haloacid dehalogenase-like hydrolase. (600 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (466 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (591 aa)
ADZ10329.1(S)-2-hydroxy-acid oxidase; KEGG: dat:HRM2_41110 FMN-dependent dehydrogenase family protein (TIM barrel family protein); PFAM: Rubredoxin-type Fe(Cys)4 protein; FMN-dependent dehydrogenase. (419 aa)
ADZ10330.1KEGG: gtn:GTNG_2275 aspartate ammonia-lyase; PFAM: Lyase 1, N-terminal; Fumarase C, C-terminal. (461 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: SAICAR synthetase; HAMAP: SAICAR synthetase; KEGG: mth:MTH170 phosphoribosylaminoimidazole-succinocarboxamide synthase. (248 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (84 aa)
purQPhosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (217 aa)
ADZ10346.1KEGG: mfv:Mfer_0596 hydrolase, TatD family; TIGRFAM: Deoxyribonuclease, TatD Mg-dependent, prokaryote; PFAM: Deoxyribonuclease, TatD-related. (252 aa)
uppSUndecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (255 aa)
thyAThymidylate synthase, methanogen type; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (205 aa)
ADZ10411.1PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mth:MTH775 methionine synthase. (324 aa)
carATIGRFAM: Carbamoyl-phosphate synthase, small subunit; KEGG: mmg:MTBMA_c13800 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (360 aa)
carBSMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: mmg:MTBMA_c13790 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1060 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (451 aa)
hisCPFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: mth:MTH1587 histidinol-phosphate aminotransferase. (366 aa)
ADZ10510.1KEGG: mfv:Mfer_0127 anaerobic ribonucleoside-triphosphate reductase activating protein; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic-like; PFAM: Radical SAM. (247 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (224 aa)
guaAAGMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (190 aa)
guaABGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (308 aa)
ADZ10737.1PfkB domain protein; PFAM: Carbohydrate/purine kinase; KEGG: mth:MTH1544 ribokinase; Belongs to the carbohydrate kinase PfkB family. (303 aa)
ADZ10744.1TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; KEGG: mmg:MTBMA_c01230 anaerobic ribonucleotide-triphosphate reductase; PFAM: ATP-cone. (773 aa)
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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