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| | ADZ10337.1 | KEGG: mfv:Mfer_1298 uroporphyrinogen III synthase HEM4; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase. (261 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (217 aa) |
| | ADZ10332.1 | TIGRFAM: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; KEGG: mmh:Mmah_0725 succinate dehydrogenase subunit A; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal. (596 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (591 aa) |
| | ADZ10322.1 | PFAM: Creatininase; KEGG: mmg:MTBMA_c10310 creatinine amidohydrolase. (235 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (466 aa) |
| | ADZ10310.1 | KEGG: dae:Dtox_1747 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (278 aa) |
| | ADZ10294.1 | TIGRFAM: Phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: mru:mru_0388 phosphoserine phosphatase SerB; PFAM: Haloacid dehalogenase-like hydrolase. (600 aa) |
| | ADZ10290.1 | TIGRFAM: Isopropylmalate/citramalate/homocitrate synthase; KEGG: mmg:MTBMA_c02150 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa) |
| | ADZ10288.1 | PFAM: Protein of unknown function DUF98; KEGG: mth:MTH1632 hypothetical protein. (177 aa) |
| | ADZ10282.1 | KEGG: mfv:Mfer_0622 prephenate dehydrogenase. (435 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (461 aa) |
| | ADZ10266.1 | TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; KEGG: mfv:Mfer_0097 anthranilate synthase, component II; PFAM: Glutamine amidotransferase class-I, C-terminal. (191 aa) |
| | ADZ10265.1 | KEGG: mfv:Mfer_0096 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase. (278 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mfv:Mfer_0095 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (235 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | ADZ10742.1 | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: gfo:GFO_2325 M20 family peptidase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (417 aa) |
| | lysS | PFAM: Lysyl-tRNA synthetase, class Ic; TIGRFAM: Lysyl-tRNA synthetase, class I; HAMAP: Lysyl-tRNA synthetase, class I, archaeal-type; KEGG: mth:MTH1542 hypothetical protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (525 aa) |
| | ADZ10728.1 | TIGRFAM: Formate dehydrogenase, alpha subunit; PFAM: Molybdopterin oxidoreductase; Molybdopterin oxidoreductase, Fe4S4 domain; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; 4Fe-4S binding domain; Molydopterin dinucleotide-binding domain; KEGG: mth:MTH1552 formate dehydrogenase, alpha subunit-like protein; SMART: Molybdopterin oxidoreductase, Fe4S4 domain; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding. (901 aa) |
| | ADZ10697.1 | TIGRFAM: Glutamine synthetase type I; KEGG: mth:MTH1570 glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp. (442 aa) |
| | ADZ10668.1 | Butyrate--CoA ligase; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase/ligase. (557 aa) |
| | ADZ10667.1 | PFAM: 4Fe-4S binding domain; KEGG: mmq:MmarC5_0318 ketoisovalerate ferredoxin oxidoreductase, delta subunit. (102 aa) |
| | ADZ10666.1 | 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: mmp:MMP1272 2-ketoisovalerate ferredoxin reductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (351 aa) |
| | ADZ10665.1 | PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: mmp:MMP1271 2-oxoisovalerate oxidoreductase subunit alpha. (481 aa) |
| | ADZ10664.1 | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: mmg:MTBMA_c09230 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (571 aa) |
| | ADZ10663.1 | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: mmg:MTBMA_c09240 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (286 aa) |
| | gatD | Glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (437 aa) |
| | cofD | LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa) |
| | cofE | F420-0:gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (253 aa) |
| | ADZ10621.1 | KEGG: mmg:MTBMA_c14150 2-oxoglutarate synthase, subunit alpha; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal. (375 aa) |
| | ADZ10620.1 | KEGG: mth:MTH1034 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (288 aa) |
| | ADZ10619.1 | KEGG: mru:mru_1826 2-oxoglutarate ferredoxin oxidoreductase subunit gamma KorC; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (182 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa) |
| | pgk | HAMAP: Phosphoglycerate kinase; KEGG: mth:MTH1042 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (408 aa) |
| | gap-2 | KEGG: mmg:MTBMA_c13910 glyceraldehyde 3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type II; HAMAP: Glyceraldehyde-3-phosphate dehydrogenase; SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain. (338 aa) |
| | cimA | Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (501 aa) |
| | guaAA | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (190 aa) |
| | pdaD | KEGG: mth:MTH870 hypothetical protein; TIGRFAM: Pyruvoyl-dependent arginine decarboxylase; PFAM: Pyruvoyl-dependent arginine decarboxylase; Belongs to the PdaD family. (147 aa) |
| | hisC | PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: mth:MTH1587 histidinol-phosphate aminotransferase. (366 aa) |
| | apgM-2 | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (403 aa) |
| | ADZ10470.1 | KEGG: mth:MTH1684 hypothetical protein; TIGRFAM: Putative methanogenesis marker 16 metalloprotein; PFAM: Domain of unknown function DUF39; 4Fe-4S binding domain. (423 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (905 aa) |
| | ADZ10458.1 | TIGRFAM: Phosphosulpholactate synthase; KEGG: mth:MTH1674 hypothetical protein; PFAM: (2R)-phospho-3-sulpholactate synthase, ComA. (257 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | carB | SMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: mmg:MTBMA_c13790 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1060 aa) |
| | carA | TIGRFAM: Carbamoyl-phosphate synthase, small subunit; KEGG: mmg:MTBMA_c13800 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (360 aa) |
| | ADZ10427.1 | PFAM: ATP-grasp fold, DUF201-type; KEGG: mst:Msp_1215 hypothetical protein. (379 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (510 aa) |
| | ADZ10411.1 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mth:MTH775 methionine synthase. (324 aa) |
| | ADZ10392.1 | PFAM: Histidine biosynthesis; KEGG: mru:mru_1337 HisA/HisF family protein HisAF; Belongs to the HisA/HisF family. (223 aa) |
| | ADZ10387.1 | KEGG: mth:MTH209 hypothetical protein; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, CTE7; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase-like hydrolase. (226 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa) |
| | hisS | ATP phosphoribosyltransferase regulatory subunit; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; HAMAP: ATP phosphoribosyltransferase regulatory subunit; Histidyl-tRNA synthetase, class IIa, subgroup; KEGG: mth:MTH244 histidyl-tRNA synthetase. (429 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (132 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). (365 aa) |
| | ADZ08864.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (399 aa) |
| | argH | PFAM: Lyase 1, N-terminal; TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: mmg:MTBMA_c07190 argininosuccinate lyase. (469 aa) |
| | ADZ08832.1 | TIGRFAM: Isopropylmalate/isohomocitrate dehydrogenase; KEGG: mth:MTH184 multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (329 aa) |
| | ADZ08830.1 | HAMAP: Malate dehydrogenase, NAD-dependent; KEGG: mmg:MTBMA_c06400 malate dehydrogenase; PFAM: Lactate/malate dehydrogenase, N-terminal; Lactate/malate dehydrogenase, C-terminal; Belongs to the LDH/MDH superfamily. (315 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (191 aa) |
| | ADZ08827.1 | PFAM: Glutamine amidotransferase, class-II; KEGG: mmg:MTBMA_c06420 glutamate synthase, subunit 1. (305 aa) |
| | ADZ08824.1 | KEGG: mmg:MTBMA_c06450 glutamate synthase, subunit 2; PFAM: Glutamate synthase, central-C; 4Fe-4S binding domain; Belongs to the glutamate synthase family. (503 aa) |
| | ADZ08818.1 | TIGRFAM: Acetate-CoA ligase; KEGG: mmg:MTBMA_c01900 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase. (649 aa) |
| | ADZ08817.1 | KEGG: mfv:Mfer_0624 acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain. (536 aa) |
| | ADZ08815.1 | Serine--pyruvate transaminase; KEGG: mmg:MTBMA_c01880 aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase. (389 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (322 aa) |
| | ADZ08750.1 | PFAM: Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal; NADP oxidoreductase, coenzyme F420-dependent; KEGG: mmg:MTBMA_c03230 dehydrogenase. (275 aa) |
| | ADZ08742.1 | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: mth:MTH1740 pyruvate ferredoxin oxidoreductase subunit gamma/delta; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (177 aa) |
| | ADZ08741.1 | KEGG: mmg:MTBMA_c03150 pyruvate synthase, subunit D; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S binding domain. (80 aa) |
| | ADZ08740.1 | KEGG: mmg:MTBMA_c03140 pyruvate synthase, subunit A; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (382 aa) |
| | ADZ08739.1 | KEGG: mth:MTH1738 pyruvate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (288 aa) |
| | ADZ08679.1 | MmgE/PrpD family protein; PFAM: MmgE/PrpD; KEGG: mfv:Mfer_0669 MmgE/PrpD family protein. (444 aa) |
| | ADZ08674.1 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: mmg:MTBMA_c13560 phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT. (525 aa) |
| | ADZ08668.1 | t-RNA-binding domain-containing protein; PFAM: tRNA-binding domain; KEGG: ton:TON_0446 putative tRNA-binding protein. (237 aa) |
| | ADZ08667.1 | Lactaldehyde dehydrogenase; KEGG: msi:Msm_0467 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; PFAM: Aldehyde dehydrogenase domain; Belongs to the aldehyde dehydrogenase family. (468 aa) |
| | ADZ08642.1 | KEGG: mbn:Mboo_0945 cytosine deaminase; PFAM: CMP/dCMP deaminase, zinc-binding. (157 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (392 aa) |
| | comB | PFAM: 2-phosphosulpholactate phosphatase; TIGRFAM: 2-phosphosulpholactate phosphatase; HAMAP: 2-phosphosulpholactate phosphatase ComB; KEGG: mfv:Mfer_1236 2-phosphosulfolactate phosphatase. (222 aa) |
| | ADZ08572.1 | Malate dehydrogenase (NADP(+)); KEGG: mmg:MTBMA_c15830 sulfolactate dehydrogenase; PFAM: Malate/L-lactate dehydrogenase. (343 aa) |
| | ADZ08571.1 | KEGG: msi:Msm_0080 sulfopyruvate decarboxylase, ComD; TIGRFAM: Sulfopyruvate decarboxylase, alpha subunit. (163 aa) |
| | ADZ08570.1 | TIGRFAM: Sulfopyruvate decarboxylase, beta subunit; KEGG: mmg:MTBMA_c15850 sulfopyruvate decarboxylase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (182 aa) |
| | hisE | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; KEGG: msi:Msm_1103 phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like. (97 aa) |
| | ADZ08565.1 | KEGG: mfv:Mfer_1224 radical sam domain protein; PFAM: Radical SAM; Biotin/thiamin synthesis-associated protein; SMART: Elongator protein 3/MiaB/NifB. (333 aa) |
| | ADZ08556.1 | TIGRFAM: Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; KEGG: mth:MTH1216 pantothenate metabolism flavoprotein; PFAM: DNA/pantothenate metabolism flavoprotein, C-terminal; Flavoprotein. (381 aa) |
| | ADZ08552.1 | KEGG: mmg:MTBMA_c16050 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (276 aa) |
| | ADZ08540.1 | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: mmg:MTBMA_c16200 homoserine dehydrogenase. (426 aa) |
| | ADZ08530.1 | Long-chain-fatty-acid--CoA ligase; KEGG: shi:Shel_23800 AMP-forming long-chain acyl-CoA synthetase; PFAM: Male sterility, NAD-binding; AMP-dependent synthetase/ligase. (935 aa) |
| | argG | PFAM: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: mth:MTH1254 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (393 aa) |
| | ADZ08494.1 | Beta-lactamase domain protein; KEGG: mth:MTH1267 hypothetical protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (204 aa) |
| | ADZ08492.1 | KEGG: dth:DICTH_0191 pyrroline-5-carboxylate reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent. (272 aa) |
| | ADZ08424.1 | Cysteine desulfurase; KEGG: mmg:MTBMA_c17750 cystein desulfurase; PFAM: Aminotransferase, class V/Cysteine desulfurase. (402 aa) |
| | ADZ08423.1 | KEGG: mru:mru_0103 3-isopropylmalate dehydrogenase LeuB; PFAM: Isocitrate/isopropylmalate dehydrogenase. (334 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (421 aa) |
| | ADZ08413.1 | Archaeoflavoprotein, MJ0208 family; KEGG: mmg:MTBMA_c17660 conserved hypothetical protein containing a ferredoxin domain; TIGRFAM: Archaeoflavoprotein MJ0208; PFAM: Flavoprotein; 4Fe-4S binding domain. (230 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1060 aa) |
| | ADZ08386.1 | PFAM: Iron sulphur-containing domain, CDGSH-type; Ferredoxin soy-like; KEGG: mac:MA0986 hypothetical protein. (241 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (274 aa) |
| | argD | PFAM: Aminotransferase class-III; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: mfv:Mfer_0532 acetylornithine aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (428 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (292 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase, eukaryotic; KEGG: mmg:MTBMA_c00020 aspartate carbamoyltransferase. (307 aa) |
| | ADZ08358.1 | PFAM: Domain of unknown function DUF521; KEGG: msi:Msm_1192 hypothetical protein. (396 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa) |
| | ADZ08346.1 | KEGG: mfv:Mfer_0053 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (166 aa) |
| | ADZ08345.1 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: mth:MTH1444 acetolactate synthase catalytic subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (577 aa) |
| | ADZ08343.1 | PFAM: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; TIGRFAM: Ornithine carbamoyltransferase; HAMAP: Ornithine carbamoyltransferase; KEGG: mfv:Mfer_0050 ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (300 aa) |
| | argS | KEGG: mth:MTH1447 arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic; Belongs to the class-I aminoacyl-tRNA synthetase family. (561 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: mmg:MTBMA_c00370 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (551 aa) |
| | thrS | TIGRFAM: Threonyl-tRNA synthetase, class IIa; KEGG: mth:MTH1455 threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase, editing domain, archaea; Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; Belongs to the class-II aminoacyl-tRNA synthetase family. (614 aa) |
| | cbiA | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (451 aa) |
| | hisB | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: mru:mru_2139 bifunctional imidazoleglycerol-phosphate dehydratase HisB; PFAM: Imidazoleglycerol-phosphate dehydratase. (191 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | ADZ08319.1 | SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; TIGRFAM: Isopropylmalate/citramalate/homocitrate synthase; KEGG: mth:MTH1481 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa) |
| | ala | Alanine dehydrogenase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (335 aa) |
| | ADZ08300.1 | PFAM: Cobyrinic acid a,c-diamide synthase; CobB/CobQ-like glutamine amidotransferase; KEGG: mmg:MTBMA_c00820 cobyrinic acid a,c-diamide synthase-related protein. (497 aa) |
| | sepS | O-phosphoseryl-tRNA(Cys) synthetase; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys). (531 aa) |
| | ADZ08296.1 | L-aspartate oxidase; KEGG: mfv:Mfer_0085 thiol-driven fumarate reductase, flavoprotein subunit; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal. (558 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa) |
| | ADZ08284.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mmg:MTBMA_c11520 glyoxalase family protein. (116 aa) |
| | leuS | TIGRFAM: Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic; KEGG: mst:Msp_0171 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (958 aa) |
| | ADZ08269.1 | Ureidoglycolate lyase; KEGG: mfv:Mfer_0698 5-carboxymethyl-2-hydroxymuconatedelta-isomerase; PFAM: Fumarylacetoacetase, C-terminal-like. (259 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa) |
| | ADZ08265.1 | KEGG: mmg:MTBMA_c01110 coenzyme F390 synthetase; TIGRFAM: Coenzyme F390 synthetase; PFAM: AMP-dependent synthetase/ligase. (446 aa) |
| | ADZ08261.1 | PFAM: Amidohydrolase 1; KEGG: mfv:Mfer_0494 amidohydrolase. (415 aa) |
| | ADZ08256.1 | UPF0107 protein; KEGG: mth:MTH1530 hypothetical protein; HAMAP: Uncharacterised protein family UPF0107; PFAM: Domain of unknown function DUF126; Belongs to the UPF0107 family. (135 aa) |
| | ADZ09724.1 | KEGG: dae:Dtox_2167 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (246 aa) |
| | ADZ09694.1 | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: ppd:Ppro_0548 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (288 aa) |
| | ADZ09693.1 | KEGG: mmg:MTBMA_c09230 pyruvate flavodoxin/ferredoxin oxidoreductase, subunit alpha; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (573 aa) |
| | ADZ09662.1 | TIGRFAM: Glutamate decarboxylase; KEGG: cwo:Cwoe_3467 glutamate decarboxylase; PFAM: Pyridoxal phosphate-dependent decarboxylase. (481 aa) |
| | ADZ09653.1 | PFAM: Rieske [2Fe-2S] iron-sulphur domain; KEGG: nmr:Nmar_0308 Rieske (2Fe-2S) domain-containing protein. (115 aa) |
| | ADZ09650.1 | Beta-lactamase domain protein; KEGG: cdl:CDR20291_0406 putative hydrolase; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (214 aa) |
| | ADZ09617.1 | Propanoyl-CoA C-acyltransferase; KEGG: mmg:MTBMA_c11890 acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal. (383 aa) |
| | cpgS | Cyclic 2,3-diphosphoglycerate synthetase; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (459 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (467 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (439 aa) |
| | aroA-2 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (266 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (374 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (658 aa) |
| | ADZ09541.1 | KEGG: cpy:Cphy_3485 peptidase T-like protein; TIGRFAM: Peptidase M20B, peptidase T; PFAM: Peptidase M20, dimerisation; Peptidase M20. (381 aa) |
| | ADZ09510.1 | KEGG: bba:Bd3795 cystathionine gamma-lyase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (377 aa) |
| | ADZ09506.1 | MOSC domain containing protein; PFAM: Molybdenum cofactor sulfurase, C-terminal; KEGG: dhd:Dhaf_1402 MOSC domain containing protein. (157 aa) |
| | ADZ09500.1 | Glutathione synthase; KEGG: cac:CA_C1540 hypothetical protein; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain. (328 aa) |
| | glyA-2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (421 aa) |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (387 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (489 aa) |
| | ADZ09455.1 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: mbu:Mbur_0797 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (439 aa) |
| | cysS | SMART: Cysteinyl-tRNA synthetase, class Ia, DALR; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: mst:Msp_0124 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; Belongs to the class-I aminoacyl-tRNA synthetase family. (467 aa) |
| | ADZ09445.1 | KEGG: mmg:MTBMA_c05680 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase, catalytic domain; PFAM: ATP phosphoribosyltransferase, catalytic domain. (329 aa) |
| | ADZ09423.1 | TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: mru:mru_1574 cysteine synthase CysKM1; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (328 aa) |
| | ADZ09422.1 | KEGG: mvn:Mevan_0177 serine O-acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (237 aa) |
| | ADZ09420.1 | KEGG: mst:Msp_0490 putative asparagine synthetase; TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (495 aa) |
| | ADZ09417.1 | KEGG: mst:Msp_0487 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding. (339 aa) |
| | apgM | Proposed homoserine kinase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (401 aa) |
| | ADZ09414.1 | PFAM: CobB/CobQ-like glutamine amidotransferase; KEGG: mfv:Mfer_1210 CobB/CobQ domain protein glutamine amidotransferase. (241 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | ADZ09341.1 | KEGG: mmg:MTBMA_c11460 metal-dependent hydrolase. (258 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | pheS | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain 2, bacterial/archaeal; KEGG: mmg:MTBMA_c11370 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (522 aa) |
| | ADZ09300.1 | TIGRFAM: Bacterial carbamate kinase; KEGG: mem:Memar_0247 carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (325 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (469 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (225 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (227 aa) |
| | ADZ09255.1 | Phenylacetate--CoA ligase; KEGG: mmg:MTBMA_c04250 coenzyme F390 synthetase; PFAM: AMP-dependent synthetase/ligase. (432 aa) |
| | ADZ09225.1 | Lactate utilization protein B/C; PFAM: Domain of unknown function DUF162; KEGG: mmg:MTBMA_c05900 conserved iron-sulfur cluster binding protein. (400 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (398 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (336 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain; SMART: B3/B4 tRNA-binding domain; tRNA synthetase, B5; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic; KEGG: mmg:MTBMA_c11660 phenylalanyl-tRNA synthetase, beta chain; HAMAP: Phenylalanyl-tRNA synthetase beta chain 2, bacterial/archaeal; PFAM: tRNA synthetase, B5; B3/B4 tRNA-binding domain. (553 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (887 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (420 aa) |
| | ADZ09152.1 | TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: mst:Msp_0210 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (441 aa) |
| | ADZ09111.1 | KEGG: mev:Metev_2283 capsular polysaccharide biosynthesis protein. (440 aa) |
| | ADZ09096.1 | PFAM: Asparagine synthase; KEGG: amr:AM1_1915 asparagine synthase, putative. (621 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (564 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (418 aa) |
| | ADZ09011.1 | TIGRFAM: Pyridoxal phosphate-dependent transferase, archaea; KEGG: msi:Msm_0767 selenocysteine synthase, SelA. (386 aa) |
| | ADZ08979.1 | PFAM: Bacterial transferase hexapeptide repeat; KEGG: mfv:Mfer_0757 acetyl / acyl transferase related protein. (203 aa) |
| | ADZ08942.1 | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (314 aa) |
| | ADZ08939.1 | Methanogenesis marker protein 15; KEGG: mth:MTH1869 activator of (R)-2-hydroxyglutaryl-CoA; TIGRFAM: Putative methanogenesis marker protein 15; CoA enzyme activase; PFAM: ATPase, BadF/BadG/BcrA/BcrD type. (410 aa) |
| | ADZ08922.1 | KEGG: sus:Acid_4279 beta-lactamase domain-containing protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (275 aa) |
| | ADZ08920.1 | Phenylacetate--CoA ligase; KEGG: mth:MTH161 coenzyme F390 synthetase III; PFAM: AMP-dependent synthetase/ligase. (432 aa) |
| | ADZ08918.1 | TIGRFAM: Indolepyruvate ferredoxin oxidoreductase, beta subunit; KEGG: mst:Msp_1042 indolepyruvate oxidoreductase subunit beta; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (197 aa) |
| | ADZ08917.1 | Indolepyruvate ferredoxin oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (616 aa) |
| | ADZ08912.1 | KEGG: mmg:MTBMA_c04160 glycyl-tRNA synthetase; TIGRFAM: Glycyl-tRNA synthetase, alpha2 dimer; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding. (575 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | ADZ10256.1 | KEGG: mmg:MTBMA_c02450 glutamate synthase, alpha subunit related protein; PFAM: Glutamate synthase, central-C; Belongs to the glutamate synthase family. (499 aa) |
| | ADZ10255.1 | Acetolactate synthase; KEGG: mth:MTH476 pyruvate dehydrogenase / acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Rubredoxin-type Fe(Cys)4 protein; Thiamine pyrophosphate enzyme, central domain. (585 aa) |
| | ADZ10227.1 | UPF0597 protein yhaM; HAMAP: Uncharacterised protein family UPF0597; KEGG: ckr:CKR_0543 hypothetical protein; Belongs to the UPF0597 family. (436 aa) |
| | ADZ10186.1 | NIL domain-containing protein; KEGG: mmg:MTBMA_c12510 conserved hypothetical protein containing a ferredoxin domain; PFAM: NIL domain; 4Fe-4S binding domain; SMART: NIL domain. (128 aa) |
| | ADZ10185.1 | Protein of unknown function DUF39; KEGG: mmg:MTBMA_c12520 CBS domain containing protein; PFAM: Domain of unknown function DUF39; Cystathionine beta-synthase, core; SMART: Cystathionine beta-synthase, core. (514 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: mmg:MTBMA_c12400 phosphoribosylformimino-5-aminoimidazole ribonucleotide isomerase. (245 aa) |
| | hacB | 3-isopropylmalate dehydratase small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD f [...] (163 aa) |
| | ADZ10158.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mpl:Mpal_1261 glyoxalase/bleomycin resistance protein/dioxygenase. (119 aa) |
| | aroK | PFAM: GHMP kinase; GHMP kinase, C-terminal; TIGRFAM: Shikimate kinase, archaea; HAMAP: Shikimate kinase; KEGG: mfv:Mfer_0680 shikimate kinase. (301 aa) |
| | ADZ10129.1 | TIGRFAM: Chorismate mutase, archaeal; PFAM: Chorismate mutase, type II; KEGG: mfv:Mfer_0679 chorismate mutase, type II; SMART: Chorismate mutase. (97 aa) |
| | ADZ10127.1 | KEGG: mmg:MTBMA_c11980 aspartate kinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family. (406 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa) |
| | ADZ10118.1 | TIGRFAM: Acetate-CoA ligase; KEGG: mfv:Mfer_0074 acetyl-coenzyme a synthetase; PFAM: AMP-dependent synthetase/ligase. (633 aa) |
| | ADZ10085.1 | Methylisocitrate lyase; KEGG: ccb:Clocel_0283 2,3-dimethylmalate lyase. (276 aa) |
| | ADZ10077.1 | KEGG: cyj:Cyan7822_0613 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain. (440 aa) |
| | ADZ10073.1 | Cyclase family protein; PFAM: Putative cyclase; KEGG: mmg:MTBMA_c03680 metal-dependent hydrolase. (223 aa) |
| | ADZ10070.1 | KEGG: mma:MM_1955 cysteine desulfurase NifS; PFAM: Aminotransferase, class V/Cysteine desulfurase. (388 aa) |
| | ADZ10037.1 | PFAM: Glutamine amidotransferase class-I, C-terminal; KEGG: ckr:CKR_0323 hypothetical protein. (237 aa) |
| | ADZ09985.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: cby:CLM_0738 lactoylglutathione lyase. (118 aa) |
| | gap | KEGG: mth:MTH1009 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type II; HAMAP: Glyceraldehyde-3-phosphate dehydrogenase; SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain. (336 aa) |
| | ADZ09967.1 | KEGG: mbn:Mboo_0387 beta-lactamase domain-containing protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (225 aa) |
| | ADZ09939.1 | acetate/CoA ligase; PFAM: AMP-dependent synthetase/ligase; manually curated; KEGG: mth:MTH217 acetyl-CoA synthetase; TIGRFAM: Acetate-CoA ligase. (634 aa) |
| | ADZ09921.1 | KEGG: ccb:Clocel_3213 beta-lactamase domain-containing protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (241 aa) |
| | ADZ09912.1 | TIGRFAM: Parallel beta-helix repeat-2; KEGG: msi:Msm_0281 putative adhesin-like protein. (618 aa) |
| | ADZ09880.1 | TIGRFAM: Glutamate decarboxylase; KEGG: mba:Mbar_A2744 glutamate decarboxylase; PFAM: Pyridoxal phosphate-dependent decarboxylase. (491 aa) |
| | ppk | Polyphosphate kinase 1; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (704 aa) |
| | ADZ09774.1 | PFAM: Ketopantoate reductase ApbA/PanE, C-terminal; Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: pde:Pden_4530 2-dehydropantoate 2-reductase. (351 aa) |
