STRINGSTRING
ADZ08717.1 ADZ08717.1 ADZ08789.1 ADZ08789.1 rfcL rfcL rfcS rfcS ADZ10487.1 ADZ10487.1 ADZ09278.1 ADZ09278.1 ADZ09340.1 ADZ09340.1 lon lon ADZ10657.1 ADZ10657.1 uvrA uvrA uvrB uvrB ADZ09610.1 ADZ09610.1 ADZ09730.1 ADZ09730.1 ADZ09764.1 ADZ09764.1 ADZ09786.1 ADZ09786.1 ADZ09791.1 ADZ09791.1 kdpB kdpB ADZ10105.1 ADZ10105.1 ADZ10121.1 ADZ10121.1 hel308 hel308 ADZ10283.1 ADZ10283.1 rad50 rad50 pan pan ADZ10438.1 ADZ10438.1 ADZ08273.1 ADZ08273.1 ADZ08630.1 ADZ08630.1 ADZ08262.1 ADZ08262.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ADZ08717.1PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: mmp:MMP0982 hypothetical protein. (250 aa)
ADZ08789.1Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (183 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (491 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (347 aa)
ADZ10487.1Magnesium chelatase; PFAM: von Willebrand factor, type A; ATPase, AAA-5; KEGG: mmg:MTBMA_c09440 cobaltochelatase subunit-like protein; SMART: von Willebrand factor, type A; ATPase, AAA+ type, core. (711 aa)
ADZ09278.1SMART: ATPase, P-type cation-transporter, N-terminal; TIGRFAM: ATPase, P-type, plasma-membrane proton-efflux; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: mbu:Mbur_0068 plasma-membrane proton-efflux P-type ATPase; PFAM: ATPase, P-type, ATPase-associated domain; ATPase, P-type cation-transporter, N-terminal; Haloacid dehalogenase-like hydrolase. (825 aa)
ADZ09340.1TIGRFAM: ATPase, P type, cation/copper-transporter; ATPase, P-type, heavy metal translocating; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: mev:Metev_1829 copper-translocating P-type ATPase; PFAM: ATPase, P-type, ATPase-associated domain; Haloacid dehalogenase-like hydrolase. (685 aa)
lonAnti-sigma H sporulation factor, LonB; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (793 aa)
ADZ10657.1AAA ATPase central domain protein; KEGG: mth:MTH1011 ATP-dependent 26S protease regulatory subunit 8; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core. (373 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (968 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (653 aa)
ADZ09610.1Thermosome; KEGG: mmg:MTBMA_c06670 thermosome, subunit alpha (chaperonin subunit); TIGRFAM: Thermosome, archaeal; PFAM: Chaperonin Cpn60/TCP-1. (540 aa)
ADZ09730.1ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (285 aa)
ADZ09764.1ATPase, P-type (transporting), HAD superfamily, subfamily IC; SMART: ATPase, P-type cation-transporter, N-terminal; TIGRFAM: ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: mmg:MTBMA_c01010 cation-transporting ATPase; PFAM: ATPase, P-type, ATPase-associated domain; ATPase, P-type cation-transporter, N-terminal; Haloacid dehalogenase-like hydrolase; ATPase, P-type cation-transporter, C-terminal. (912 aa)
ADZ09786.1KEGG: mru:mru_0062 hypothetical protein. (1169 aa)
ADZ09791.1SMC domain protein; PFAM: RecF/RecN/SMC; KEGG: rlg:Rleg_1580 SMC domain protein. (815 aa)
kdpBPotassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa)
ADZ10105.1KEGG: mfv:Mfer_0531 atpase associated with various cellular activities aaa_5; PFAM: ATPase, AAA-5; SMART: ATPase, AAA+ type, core. (283 aa)
ADZ10121.1Thermosome; KEGG: mth:MTH794 chaperonin; TIGRFAM: Thermosome, archaeal; PFAM: Chaperonin Cpn60/TCP-1. (579 aa)
hel308DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (690 aa)
ADZ10283.1SMART: ATPase, AAA+ type, core; TIGRFAM: ATPase, AAA-type, CDC48; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2. (729 aa)
rad50SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (900 aa)
panProteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (410 aa)
ADZ10438.1SMART: ATPase, P-type cation-transporter, N-terminal; TIGRFAM: ATPase, P-type, calcium-transporting, PMCA-type; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: mmg:MTBMA_c13830 cation transport ATPase; PFAM: ATPase, P-type, ATPase-associated domain; ATPase, P-type cation-transporter, N-terminal; Haloacid dehalogenase-like hydrolase; ATPase, P-type cation-transporter, C-terminal. (837 aa)
ADZ08273.1Arsenite-activated ATPase ArsA; KEGG: mth:MTH1511 arsenical pump-driving ATPase; TIGRFAM: ATPase, anion-transporting. (332 aa)
ADZ08630.1PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: mth:MTH1120 NifH / MinD related protein. (261 aa)
ADZ08262.1TIGRFAM: ATPase, P-type, heavy metal translocating; ATPase, P type, cation/copper-transporter; Copper ion-binding; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: mem:Memar_1873 heavy metal translocating P-type ATPase; PFAM: ATPase, P-type, ATPase-associated domain; Heavy metal transport/detoxification protein; Haloacid dehalogenase-like hydrolase. (811 aa)
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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