Your Input: | |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (174 aa) |
| | ADZ10738.1 | Phosphomethylpyrimidine synthase; TIGRFAM: Thiamine biosynthesis protein ThiC; HAMAP: Thiamine biosynthesis protein ThiC; KEGG: mth:MTH1543 thiamine biosynthesis protein ThiC; PFAM: Thiamine biosynthesis protein ThiC. (429 aa) |
| | fdhD | Protein fdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (250 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (320 aa) |
| | ADZ10729.1 | KEGG: tpd:Teth39_0854 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; TIGRFAM: Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB), conserved domain; PFAM: Putative Fe-S cluster. (236 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa) |
| | ADZ10672.1 | Manually curated; TIGRFAM: Archaeoflavoprotein AfpA; KEGG: mtp:Mthe_0245 flavoprotein; PFAM: Flavoprotein. (191 aa) |
| | ADZ10668.1 | Butyrate--CoA ligase; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase/ligase. (557 aa) |
| | ADZ10667.1 | PFAM: 4Fe-4S binding domain; KEGG: mmq:MmarC5_0318 ketoisovalerate ferredoxin oxidoreductase, delta subunit. (102 aa) |
| | ADZ10652.1 | SMART: ATPase, AAA+ type, core; TIGRFAM: Methyl coenzyme M reductase system, component A2; KEGG: mmg:MTBMA_c13970 methyl-coenzyme M reductase, component A2; PFAM: ABC transporter-like. (533 aa) |
| | cofD | LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa) |
| | cofE | F420-0:gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (253 aa) |
| | purO | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (224 aa) |
| | asd-2 | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily. (227 aa) |
| | ADZ10640.1 | KEGG: mth:MTH1027 CDP-diacylglycerol-serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase. (239 aa) |
| | mptD | Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (122 aa) |
| | ADZ10633.1 | 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; PFAM: Phosphoribosylaminoimidazole carboxylase, core; Protein of unknown function DUF2089; KEGG: msi:Msm_1105 NCAIR mutase related protein, PurE. (254 aa) |
| | ADZ10619.1 | KEGG: mru:mru_1826 2-oxoglutarate ferredoxin oxidoreductase subunit gamma KorC; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (182 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa) |
| | pgk | HAMAP: Phosphoglycerate kinase; KEGG: mth:MTH1042 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (408 aa) |
| | gap-2 | KEGG: mmg:MTBMA_c13910 glyceraldehyde 3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type II; HAMAP: Glyceraldehyde-3-phosphate dehydrogenase; SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain. (338 aa) |
| | ADZ10583.1 | TIGRFAM: Molybdenum cofactor synthesis; PFAM: MoeA, N-terminal and linker domain; Molybdopterin binding; MoeA, C-terminal, domain IV; KEGG: mfv:Mfer_0296 molybdenum cofactor synthesis domain protein; SMART: Molybdopterin binding. (412 aa) |
| | ADZ10579.1 | Geranylgeranyl reductase; KEGG: mth:MTH725 hypothetical protein; TIGRFAM: Geranylgeranyl reductase, plant/prokaryotic; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (388 aa) |
| | guaAB | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (308 aa) |
| | guaAA | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (190 aa) |
| | ADZ10558.1 | KEGG: mth:MTH871 bifunctional inositol-1 monophosphatase/fructose-1,6-bisphosphatase; PFAM: Inositol monophosphatase. (279 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (276 aa) |
| | ADZ10553.1 | PyrE-like protein; KEGG: mth:MTH876 orotate phosphoribosyltransferase-like protein; HAMAP: Orotate phosphoribosyltransferase-like; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (200 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (224 aa) |
| | ADZ10535.1 | Archaeoflavoprotein AfpA; KEGG: mtp:Mthe_0245 flavoprotein; TIGRFAM: Archaeoflavoprotein AfpA; PFAM: Flavoprotein. (185 aa) |
| | apgM-2 | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (403 aa) |
| | ADZ10483.1 | Geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (246 aa) |
| | carB | SMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: mmg:MTBMA_c13790 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1060 aa) |
| | carA | TIGRFAM: Carbamoyl-phosphate synthase, small subunit; KEGG: mmg:MTBMA_c13800 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (360 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (288 aa) |
| | thyA | Thymidylate synthase, methanogen type; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (205 aa) |
| | ADZ10341.1 | GHMP kinase; KEGG: mst:Msp_1187 kinase; manually curated; PFAM: GHMP kinase. (298 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (217 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (84 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: SAICAR synthetase; HAMAP: SAICAR synthetase; KEGG: mth:MTH170 phosphoribosylaminoimidazole-succinocarboxamide synthase. (248 aa) |
| | ADZ10326.1 | KEGG: mmz:MmarC7_1587 helix-turn-helix domain-containing protein; PFAM: Helix-turn-helix type 3; Cupin 2, conserved barrel; SMART: Helix-turn-helix type 3. (190 aa) |
| | ADZ10322.1 | PFAM: Creatininase; KEGG: mmg:MTBMA_c10310 creatinine amidohydrolase. (235 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (466 aa) |
| | ADZ10310.1 | KEGG: dae:Dtox_1747 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (278 aa) |
| | ADZ10291.1 | Adenylyl cyclase CyaB; KEGG: mmg:MTBMA_c02140 adenylate cyclase; TIGRFAM: Adenylyl cyclase CyaB; PFAM: Adenylate cyclase. (180 aa) |
| | ADZ10253.1 | PFAM: UbiA prenyltransferase; KEGG: mth:MTH275 hypothetical protein. (287 aa) |
| | ADZ10252.1 | Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (395 aa) |
| | ADZ10207.1 | PFAM: NUDIX hydrolase domain; KEGG: mmg:MTBMA_c05710 hydrolase. (166 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (216 aa) |
| | ADZ10179.1 | PFAM: Phosphomethylpyrimidine kinase; Histidine triad (HIT) protein; KEGG: mmg:MTBMA_c12580 phosphomethylpyrimidine kinase. (366 aa) |
| | ribL | Cytidyltransferase-related domain protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (147 aa) |
| | carS | UPF0290 protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (172 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (221 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (156 aa) |
| | ADZ10118.1 | TIGRFAM: Acetate-CoA ligase; KEGG: mfv:Mfer_0074 acetyl-coenzyme a synthetase; PFAM: AMP-dependent synthetase/ligase. (633 aa) |
| | ADZ10010.1 | PFAM: Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain; KEGG: mba:Mbar_A3327 hypothetical protein. (140 aa) |
| | gap | KEGG: mth:MTH1009 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type II; HAMAP: Glyceraldehyde-3-phosphate dehydrogenase; SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain. (336 aa) |
| | ADZ09939.1 | acetate/CoA ligase; PFAM: AMP-dependent synthetase/ligase; manually curated; KEGG: mth:MTH217 acetyl-CoA synthetase; TIGRFAM: Acetate-CoA ligase. (634 aa) |
| | ADZ09930.1 | NAD(+) diphosphatase; KEGG: cce:Ccel_2937 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; NADH pyrophosphatase-like, N-terminal; Zinc ribbon, NADH pyrophosphatase. (290 aa) |
| | ADZ09910.1 | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; KEGG: rci:LRC477 prenyltransferase; PFAM: UbiA prenyltransferase. (281 aa) |
| | ADZ09880.1 | TIGRFAM: Glutamate decarboxylase; KEGG: mba:Mbar_A2744 glutamate decarboxylase; PFAM: Pyridoxal phosphate-dependent decarboxylase. (491 aa) |
| | ADZ09774.1 | PFAM: Ketopantoate reductase ApbA/PanE, C-terminal; Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: pde:Pden_4530 2-dehydropantoate 2-reductase. (351 aa) |
| | ADZ09771.1 | Deoxyguanosinetriphosphate triphosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD domain; manually curated; KEGG: ccb:Clocel_3591 deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain. (661 aa) |
| | ADZ09662.1 | TIGRFAM: Glutamate decarboxylase; KEGG: cwo:Cwoe_3467 glutamate decarboxylase; PFAM: Pyridoxal phosphate-dependent decarboxylase. (481 aa) |
| | ADZ09631.1 | KEGG: mth:MTH1823 hypothetical protein. (152 aa) |
| | ADZ09615.1 | KEGG: fpl:Ferp_1321 rhodanese domain protein; PFAM: Rhodanese-like; SMART: Rhodanese-like. (116 aa) |
| | cpgS | Cyclic 2,3-diphosphoglycerate synthetase; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (459 aa) |
| | ADZ09518.1 | NADH dehydrogenase (quinone); KEGG: mmg:MTBMA_c07980 energy-converting hydrogenase A, subunit O; PFAM: NADH-quinone oxidoreductase, subunit D; Nickel-dependent hydrogenase, large subunit. (381 aa) |
| | thiI | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (387 aa) |
| | thi4-2 | Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (275 aa) |
| | pdxS | Pyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa) |
| | ADZ09429.1 | KEGG: fpl:Ferp_2212 MoaD family protein; TIGRFAM: MoaD, archaeal; PFAM: ThiamineS. (93 aa) |
| | ADZ09420.1 | KEGG: mst:Msp_0490 putative asparagine synthetase; TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (495 aa) |
| | apgM | Proposed homoserine kinase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (401 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | ADZ09408.1 | PFAM: Protein of unknown function DUF137; KEGG: mmg:MTBMA_c08300 hypothetical protein. (250 aa) |
| | ADZ09297.1 | KEGG: mpl:Mpal_2117 rhodanese domain protein; PFAM: Rhodanese-like; SMART: Rhodanese-like. (114 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa) |
| | egsA | 3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (347 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (227 aa) |
| | ADZ09239.1 | PFAM: Cytidylyltransferase; TIGRFAM: Nicotinamide-nucleotide adenylyltransferase, archaeal type; Cytidyltransferase-related; HAMAP: Nicotinamide-nucleotide adenylyltransferase, archaeal type; KEGG: mmg:MTBMA_c06000 nicotinamide-nucleotide adenylyltransferase. (174 aa) |
| | ADZ09238.1 | PFAM: Molybdopterin biosynthesis MoaE; KEGG: mru:mru_1268 molybdenum cofactor biosynthesis protein MoaE. (145 aa) |
| | ADZ09237.1 | KEGG: mth:MTH148 hypothetical protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain. (386 aa) |
| | ADZ09232.1 | KEGG: mfv:Mfer_0255 thymidylate synthase, methanogen type. (215 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (203 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (495 aa) |
| | ADZ09227.1 | PFAM: Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain; KEGG: pth:PTH_0218 hypothetical protein. (129 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (155 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (340 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (329 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (418 aa) |
| | cmk | KEGG: msi:Msm_0734 cytidylate kinase; TIGRFAM: Cytidylate kinase, putative; HAMAP: Cytidylate kinase, putative. (176 aa) |
| | adkA | KEGG: msi:Msm_0737 adenylate kinase; HAMAP: Adenylate kinase; Belongs to the archaeal adenylate kinase family. (186 aa) |
| | ADZ08969.1 | UPF0244 protein yjjX; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (176 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (153 aa) |
| | ADZ08934.1 | Methanogenesis marker protein 2; KEGG: mmg:MTBMA_c04350 SelD-related protein; TIGRFAM: Putative methanogenesis marker protein 2; PFAM: AIR synthase-related protein; AIR synthase-related protein, C-terminal. (328 aa) |
| | ADZ08931.1 | TIGRFAM: Molybdenum cofactor synthesis; PFAM: Molybdopterin binding; KEGG: mth:MTH1861 molybdenum cofactor biosynthesis MoaB; SMART: Molybdopterin binding. (174 aa) |
| | ADZ08918.1 | TIGRFAM: Indolepyruvate ferredoxin oxidoreductase, beta subunit; KEGG: mst:Msp_1042 indolepyruvate oxidoreductase subunit beta; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (197 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (201 aa) |
| | ADZ08897.1 | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (279 aa) |
| | ADZ08878.1 | TIGRFAM: Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type; KEGG: mfv:Mfer_0012 3-hydroxy-3-methylglutaryl-coenzyme a reductase; PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II; Belongs to the HMG-CoA reductase family. (402 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (152 aa) |
| | ADZ08851.1 | UPF0218 protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (169 aa) |
| | ADZ08254.1 | KEGG: mth:MTH1537 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase C-terminal metazoa/fungi; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (449 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (277 aa) |
| | ADZ08298.1 | Protein of unknown function DUF120; PFAM: Riboflavin kinase, CTP-dependent, archaeal; KEGG: mru:mru_2174 riboflavin kinase RibK. (122 aa) |
| | ADZ08332.1 | KEGG: sfu:Sfum_0396 HAD superfamily hydrolase. (406 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: mfv:Mfer_0051 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (441 aa) |
| | surE | Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa) |
| | ADZ08355.1 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (186 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase, eukaryotic; KEGG: mmg:MTBMA_c00020 aspartate carbamoyltransferase. (307 aa) |
| | ADZ08399.1 | TIGRFAM: Molybdenum cofactor synthesis; PFAM: MoeA, N-terminal and linker domain; Molybdopterin binding; MoeA, C-terminal, domain IV; KEGG: mmg:MTBMA_c17560 molybdenum cofactor biosynthesis protein; SMART: Molybdopterin binding. (404 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (717 aa) |
| | ADZ08410.1 | Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: msi:Msm_1165 phosphohydrolase (metal-dependent). (294 aa) |
| | ADZ08413.1 | Archaeoflavoprotein, MJ0208 family; KEGG: mmg:MTBMA_c17660 conserved hypothetical protein containing a ferredoxin domain; TIGRFAM: Archaeoflavoprotein MJ0208; PFAM: Flavoprotein; 4Fe-4S binding domain. (230 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (340 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (341 aa) |
| | hpt | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (190 aa) |
| | ADZ08837.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: mru:mru_0503 phosphatidylglycerophosphate synthase PgsA; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (195 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (191 aa) |
| | ADZ08818.1 | TIGRFAM: Acetate-CoA ligase; KEGG: mmg:MTBMA_c01900 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase. (649 aa) |
| | mptE | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (273 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa) |
| | ADZ08803.1 | dUTP diphosphatase; KEGG: msi:Msm_0687 deoxycytidine-triphosphate deaminase, dcd; PFAM: DeoxyUTP pyrophosphatase domain. (151 aa) |
| | ADZ08789.1 | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (183 aa) |
| | thi4 | Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (259 aa) |
| | tmk | PFAM: Thymidylate kinase; TIGRFAM: Thymidylate kinase; HAMAP: Thymidylate kinase; KEGG: msi:Msm_0520 thymidylate kinase, Tmk. (191 aa) |
| | ADZ08768.1 | Digeranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (280 aa) |
| | ADZ08760.1 | TIGRFAM: Methyl coenzyme M reductase system, component A2; PFAM: ABC transporter-like; KEGG: mmg:MTBMA_c13970 methyl-coenzyme M reductase, component A2; SMART: ATPase, AAA+ type, core. (530 aa) |
| | ADZ08742.1 | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: mth:MTH1740 pyruvate ferredoxin oxidoreductase subunit gamma/delta; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (177 aa) |
| | ADZ08741.1 | KEGG: mmg:MTBMA_c03150 pyruvate synthase, subunit D; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S binding domain. (80 aa) |
| | ADZ08740.1 | KEGG: mmg:MTBMA_c03140 pyruvate synthase, subunit A; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (382 aa) |
| | ADZ08739.1 | KEGG: mth:MTH1738 pyruvate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (288 aa) |
| | ADZ08723.1 | Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (385 aa) |
| | cdhE | CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (462 aa) |
| | cdhC | CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (468 aa) |
| | cdhA | Acetyl-CoA decarbonylase/synthase complex subunit alpha; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (781 aa) |
| | ADZ08706.1 | Beta-lactamase domain protein; KEGG: mmg:MTBMA_c14810 hydrolase; PFAM: Beta-lactamase-like; Rhodanese-like; SMART: Beta-lactamase-like; Rhodanese-like. (455 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | atpB | V-type ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpA | V-type ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (583 aa) |
| | atpF | V-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (106 aa) |
| | atpC | V-type ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (385 aa) |
| | atpE | V-type proton ATPase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (207 aa) |
| | nadX | L-aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (254 aa) |
| | ADZ08667.1 | Lactaldehyde dehydrogenase; KEGG: msi:Msm_0467 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; PFAM: Aldehyde dehydrogenase domain; Belongs to the aldehyde dehydrogenase family. (468 aa) |
| | ADZ08663.1 | KEGG: mmg:MTBMA_c13670 hypothetical protein. (152 aa) |
| | ADZ08649.1 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH-like; KEGG: mmg:MTBMA_c14880 myo-inositol-1-phosphate synthase. (367 aa) |
| | ADZ08635.1 | TIGRFAM: Uracil phosphoribosyl transferase; KEGG: mmg:MTBMA_c14980 uracil phosphoribosyltransferase. (214 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (392 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (432 aa) |
| | ADZ08599.1 | Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: mth:MTH1179 hypothetical protein. (386 aa) |
| | ADZ08593.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cbi:CLJ_B1067 CDP-alcohol phosphatidyltransferase family protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (180 aa) |
| | mptA | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (321 aa) |
| | purP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (363 aa) |
| | purM | TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: msi:Msm_1039 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein; AIR synthase-related protein, C-terminal. (342 aa) |
| | ADZ08560.1 | PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase, FAD-binding domain; KEGG: mfv:Mfer_1174 oxidoreductase fad/nad(P)-binding domain protein. (264 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (300 aa) |
| | ADZ08556.1 | TIGRFAM: Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; KEGG: mth:MTH1216 pantothenate metabolism flavoprotein; PFAM: DNA/pantothenate metabolism flavoprotein, C-terminal; Flavoprotein. (381 aa) |
| | ADZ08524.1 | PFAM: NADH:ubiquinone oxidoreductase-like, 20kDa subunit; KEGG: mmg:MTBMA_c16270 energy-converting hydrogenase B, subunit M. (148 aa) |
| | nnrE | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (496 aa) |
