STRINGSTRING
leuS leuS ADZ09987.1 ADZ09987.1 ADZ09981.1 ADZ09981.1 metG metG thiI thiI cysS cysS ADZ09420.1 ADZ09420.1 ADZ09402.1 ADZ09402.1 ADZ09332.1 ADZ09332.1 ADZ09280.1 ADZ09280.1 ADZ09243.1 ADZ09243.1 ADZ09239.1 ADZ09239.1 valS valS ADZ09096.1 ADZ09096.1 gltX gltX coaD coaD ADZ08886.1 ADZ08886.1 trpS trpS ADZ08846.1 ADZ08846.1 ADZ08794.1 ADZ08794.1 tyrS tyrS ADZ08763.1 ADZ08763.1 ADZ08754.1 ADZ08754.1 ribL ribL nadE nadE argS argS ileS ileS argG argG ADZ08590.1 ADZ08590.1 ADZ08626.1 ADZ08626.1 queC queC ADZ08744.1 ADZ08744.1 lysS lysS guaAB guaAB ADZ10448.1 ADZ10448.1 ADZ10445.1 ADZ10445.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuSTIGRFAM: Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic; KEGG: mst:Msp_0171 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (958 aa)
ADZ09987.1PFAM: UspA; KEGG: mth:MTH993 hypothetical protein. (150 aa)
ADZ09981.1PFAM: Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal; UspA; KEGG: mbn:Mboo_0896 osmosensitive K+ channel His kinase sensor. (651 aa)
metGMethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (658 aa)
thiItRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (387 aa)
cysSSMART: Cysteinyl-tRNA synthetase, class Ia, DALR; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: mst:Msp_0124 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; Belongs to the class-I aminoacyl-tRNA synthetase family. (467 aa)
ADZ09420.1KEGG: mst:Msp_0490 putative asparagine synthetase; TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (495 aa)
ADZ09402.1Universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; KEGG: mmg:MTBMA_c08270 ATPase; TIGRFAM: Conserved hypothetical protein CHP03679, ATP-binding; Conserved hypothetical protein CHP00289; Domain of unknown function DUF71, ATP-binding domain; PFAM: Domain of unknown function DUF71, ATP-binding domain. (226 aa)
ADZ09332.1PFAM: UspA; KEGG: mmg:MTBMA_c14530 universal stress protein. (148 aa)
ADZ09280.1PFAM: UspA; KEGG: mth:MTH993 hypothetical protein. (147 aa)
ADZ09243.1PFAM: UspA; KEGG: mth:MTH153 hypothetical protein. (133 aa)
ADZ09239.1PFAM: Cytidylyltransferase; TIGRFAM: Nicotinamide-nucleotide adenylyltransferase, archaeal type; Cytidyltransferase-related; HAMAP: Nicotinamide-nucleotide adenylyltransferase, archaeal type; KEGG: mmg:MTBMA_c06000 nicotinamide-nucleotide adenylyltransferase. (174 aa)
valSValyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (887 aa)
ADZ09096.1PFAM: Asparagine synthase; KEGG: amr:AM1_1915 asparagine synthase, putative. (621 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (564 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (153 aa)
ADZ08886.1KEGG: mmg:MTBMA_c06890 hypothetical protein. (229 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). (365 aa)
ADZ08846.1PFAM: tRNA-specific 2-thiouridylase; KEGG: mru:mru_1475 hypothetical protein. (363 aa)
ADZ08794.1Queuosine synthesis-like protein; PFAM: Queuosine synthesis; KEGG: mfv:Mfer_0169 queuosine synthesis. (198 aa)
tyrSTyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (322 aa)
ADZ08763.1UspA domain-containing protein; PFAM: UspA. (134 aa)
ADZ08754.1Cytidyltransferase-related domain protein; KEGG: mmg:MTBMA_c03250 nucleotidyltransferase; TIGRFAM: Cytidyltransferase-related; PFAM: Cytidylyltransferase. (430 aa)
ribLCytidyltransferase-related domain protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (147 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (277 aa)
argSKEGG: mth:MTH1447 arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic; Belongs to the class-I aminoacyl-tRNA synthetase family. (561 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1060 aa)
argGPFAM: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: mth:MTH1254 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (393 aa)
ADZ08590.1Protein of unknown function UPF0021; KEGG: msi:Msm_1028 ATPase; TIGRFAM: tRNA 2-thiolation protein; PFAM: tRNA(Ile)-lysidine/2-thiocytidine synthase. (283 aa)
ADZ08626.1Protein of unknown function DUF795; PFAM: Uncharacterised protein family UPF0348; KEGG: mmg:MTBMA_c15090 nucleotidyltransferase. (365 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (228 aa)
ADZ08744.1Protein of unknown function UPF0021; KEGG: mru:mru_0562 PP-loop family protein; TIGRFAM: tRNA 2-thiolation protein; PFAM: tRNA(Ile)-lysidine/2-thiocytidine synthase. (311 aa)
lysSPFAM: Lysyl-tRNA synthetase, class Ic; TIGRFAM: Lysyl-tRNA synthetase, class I; HAMAP: Lysyl-tRNA synthetase, class I, archaeal-type; KEGG: mth:MTH1542 hypothetical protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (525 aa)
guaABGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (308 aa)
ADZ10448.1TIGRFAM: Conserved hypothetical protein CHP00268; KEGG: mmg:MTBMA_c13730 ATP-utilizing enzyme. (349 aa)
ADZ10445.1PFAM: UspA; KEGG: mmg:MTBMA_c13760 universal stress protein. (146 aa)
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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