STRINGSTRING
hemA hemA ADZ10304.1 ADZ10304.1 ADZ10422.1 ADZ10422.1 ADZ10554.1 ADZ10554.1 gap-2 gap-2 ADZ10654.1 ADZ10654.1 ala ala ilvC ilvC ADZ08492.1 ADZ08492.1 ADZ08495.1 ADZ08495.1 ADZ08505.1 ADZ08505.1 ADZ08530.1 ADZ08530.1 ADZ08540.1 ADZ08540.1 ADZ08649.1 ADZ08649.1 nadX nadX ADZ08674.1 ADZ08674.1 ADZ08750.1 ADZ08750.1 ADZ08830.1 ADZ08830.1 ADZ08869.1 ADZ08869.1 aroE aroE sucD sucD ADZ08975.1 ADZ08975.1 ADZ09089.1 ADZ09089.1 ADZ09115.1 ADZ09115.1 ADZ09116.1 ADZ09116.1 ADZ09146.1 ADZ09146.1 ADZ09152.1 ADZ09152.1 ADZ09161.1 ADZ09161.1 ADZ09169.1 ADZ09169.1 argC argC ADZ09282.1 ADZ09282.1 ADZ09283.1 ADZ09283.1 ADZ09417.1 ADZ09417.1 ADZ09535.1 ADZ09535.1 ADZ09536.1 ADZ09536.1 ADZ09774.1 ADZ09774.1 ADZ09825.1 ADZ09825.1 ADZ09877.1 ADZ09877.1 gap gap asd asd dapB dapB ADZ10282.1 ADZ10282.1 ADZ10284.1 ADZ10284.1 ADZ10302.1 ADZ10302.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (408 aa)
ADZ10304.1TIGRFAM: dTDP-glucose 4,6-dehydratase; KEGG: mst:Msp_1114 dTDP-D-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (312 aa)
ADZ10422.1TrkA-N domain protein; PFAM: Regulator of K+ conductance, N-terminal; Regulator of K+ conductance, C-terminal; KEGG: mmg:MTBMA_c16520 potassium uptake protein TrkA. (216 aa)
ADZ10554.1Oxidoreductase domain protein; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; KEGG: mth:MTH875 3-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein. (317 aa)
gap-2KEGG: mmg:MTBMA_c13910 glyceraldehyde 3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type II; HAMAP: Glyceraldehyde-3-phosphate dehydrogenase; SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain. (338 aa)
ADZ10654.1TIGRFAM: Sirohaem synthase, N-terminal; KEGG: msi:Msm_0968 bifunctional precorrin-2 oxidase/chelatase (siroheme synthase), CysG. (208 aa)
alaAlanine dehydrogenase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (335 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
ADZ08492.1KEGG: dth:DICTH_0191 pyrroline-5-carboxylate reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent. (272 aa)
ADZ08495.1TrkA-N domain protein; PFAM: Regulator of K+ conductance, N-terminal; Regulator of K+ conductance, C-terminal; KEGG: mth:MTH1265 trk system potassium uptake protein TrkA. (216 aa)
ADZ08505.1TrkA-N domain protein; PFAM: Regulator of K+ conductance, N-terminal; Ion transport 2; 3H domain; KEGG: mmg:MTBMA_c16450 transporter protein. (646 aa)
ADZ08530.1Long-chain-fatty-acid--CoA ligase; KEGG: shi:Shel_23800 AMP-forming long-chain acyl-CoA synthetase; PFAM: Male sterility, NAD-binding; AMP-dependent synthetase/ligase. (935 aa)
ADZ08540.1PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: mmg:MTBMA_c16200 homoserine dehydrogenase. (426 aa)
ADZ08649.1PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH-like; KEGG: mmg:MTBMA_c14880 myo-inositol-1-phosphate synthase. (367 aa)
nadXL-aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (254 aa)
ADZ08674.1TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: mmg:MTBMA_c13560 phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT. (525 aa)
ADZ08750.1PFAM: Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal; NADP oxidoreductase, coenzyme F420-dependent; KEGG: mmg:MTBMA_c03230 dehydrogenase. (275 aa)
ADZ08830.1HAMAP: Malate dehydrogenase, NAD-dependent; KEGG: mmg:MTBMA_c06400 malate dehydrogenase; PFAM: Lactate/malate dehydrogenase, N-terminal; Lactate/malate dehydrogenase, C-terminal; Belongs to the LDH/MDH superfamily. (315 aa)
ADZ08869.1NADPH-dependent F420 reductase; KEGG: mth:MTH248 hypothetical protein; TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent. (222 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (286 aa)
ADZ08975.1KEGG: pmx:PERMA_1747 UDP-glucuronic acid decarboxylase 1 (UDP-glucuronatedecarboxylase 1) (UXS-1); PFAM: NAD-dependent epimerase/dehydratase. (313 aa)
ADZ09089.1GDP-mannose 4,6-dehydratase; KEGG: mst:Msp_0990 GDP-D-mannose dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (415 aa)
ADZ09115.1KEGG: mba:Mbar_A0021 UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase. (321 aa)
ADZ09116.1TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: mpl:Mpal_0929 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (448 aa)
ADZ09146.1TIGRFAM: Undecaprenyl-phosphate glucose phosphotransferase, WcaJ; Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; KEGG: msi:Msm_1331 sugar transferase, WcaJ; PFAM: Bacterial sugar transferase. (463 aa)
ADZ09152.1TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: mst:Msp_0210 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (441 aa)
ADZ09161.1TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: mth:MTH836 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (432 aa)
ADZ09169.1TIGRFAM: dTDP-4-dehydrorhamnose reductase; KEGG: mfv:Mfer_0285 dTDP-4-dehydrorhamnose reductase; PFAM: dTDP-4-dehydrorhamnose reductase. (280 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (336 aa)
ADZ09282.1TrkA-N domain protein; PFAM: Regulator of K+ conductance, N-terminal; Regulator of K+ conductance, C-terminal; KEGG: mmg:MTBMA_c16520 potassium uptake protein TrkA. (218 aa)
ADZ09283.1TrkA-N domain protein; PFAM: Regulator of K+ conductance, N-terminal; Regulator of K+ conductance, C-terminal; KEGG: mth:MTH1265 trk system potassium uptake protein TrkA. (218 aa)
ADZ09417.1KEGG: mst:Msp_0487 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding. (339 aa)
ADZ09535.1KEGG: mba:Mbar_A0021 UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase. (312 aa)
ADZ09536.1GDP-mannose 4,6-dehydratase; KEGG: mst:Msp_0990 GDP-D-mannose dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (409 aa)
ADZ09774.1PFAM: Ketopantoate reductase ApbA/PanE, C-terminal; Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: pde:Pden_4530 2-dehydropantoate 2-reductase. (351 aa)
ADZ09825.1KEGG: pmx:PERMA_1747 UDP-glucuronic acid decarboxylase 1 (UDP-glucuronatedecarboxylase 1) (UXS-1); PFAM: NAD-dependent epimerase/dehydratase. (314 aa)
ADZ09877.1CoA-binding domain protein; KEGG: mbu:Mbur_1347 acyl-CoA synthetase; PFAM: CoA-binding; SMART: CoA-binding. (695 aa)
gapKEGG: mth:MTH1009 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type II; HAMAP: Glyceraldehyde-3-phosphate dehydrogenase; SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain. (336 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
ADZ10282.1KEGG: mfv:Mfer_0622 prephenate dehydrogenase. (435 aa)
ADZ10284.1Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. (417 aa)
ADZ10302.1TIGRFAM: UDP-glucose 4-epimerase; KEGG: mth:MTH631 UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase. (325 aa)
Your Current Organism:
Methanobacterium lacus
NCBI taxonomy Id: 877455
Other names: DSM 24406, JCM 17760, M. lacus, Methanobacterium lacus Borrel et al. 2012, Methanobacterium sp. 17A1, Methanobacterium sp. AL-21, strain 17A1
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